Long-term efficacy of recombinant Interferon alpha 2a in the treatment of chronic hepatitis C : A randomized prospective study comparing two dose schedules in Chinese patients

Chinese Medical Journal

Volumn 111, Issue 10, 1998, Pages 922-926

  Yao, Guangbi ^a   Ji, Yanyan ^a   Yang, Minyan ^a   Xu, Daozhen ^b   Gao, Jian ^c   Wu, Xianghui ^d   Zhang, Qingbo ^d   Hu, Dechang ^e  

^a Jingan Qu Central Hospital   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

^c SHANGHAI SECOND MEDICAL UNIVERSITY   (China)

^d FUDAN UNIVERSITY   (China)

^e ZHONGSHAN HOSPITAL OF FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; RECOMBINANT ALPHA2A INTERFERON; VIRUS RNA;

ADULT; ALOPECIA; ARTHRALGIA; ARTICLE; BONE MARROW TOXICITY; CHRONIC HEPATITIS; CLINICAL TRIAL; DRUG EFFICACY; DRUG INDUCED DISEASE; DRUG SAFETY; FEMALE; FEVER; GASTROINTESTINAL TOXICITY; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN TISSUE; LIVER FUNCTION TEST; MAJOR CLINICAL STUDY; MALAISE; MALE; MYALGIA; RASH; TREATMENT OUTCOME; VIRUS HEPATITIS;

ADOLESCENT; ADULT; AGED; ANTIVIRAL AGENTS; DRUG ADMINISTRATION SCHEDULE; FEMALE; FOLLOW-UP STUDIES; HEPATITIS C, CHRONIC; HUMANS; INTERFERON ALFA-2A; MALE; MIDDLE AGED; PROSPECTIVE STUDIES;

EID: 0038517941     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (8)

1. Fried MW, Hoofnagle JH. Therapy for hepatitis C. Semin Liver Dis 1995; 15:82.
2. Hoofnagle JH, DiBisceglie AM. The treatment of chronic viral hepatitis. N Engl J Med 1997; 336:347.
3. Bardelli F, Messori A, Rampazzo, et al. Effect of recombinant or lymphoblastoid interferon-α on alanine aminotransferase in patients with chronic hepatitis C or chronic non-A non-B hepatitis. Clin Drug Invest 1995; 9:239.
4. Alberti A, Chemello P, Bonetti C, et al. Treatment with interferons of community-acquired chronic hepatitis and cirrhosis type C. J Hepatol 1993; 17(Suppl 3): S123.
5. Poynard T, Leory V, Cohard M, et al. Meta-analysis of interferon randomized trials in the treatment of viral hepatitis C: effects of dose and duration. Hepatology 1996; 24:289.
6. Antonelli G, Gerrienti M, Turriziani O, et al. Neutralizing antibodies in interferon alpha: relative frequency in patient treatment with different interferon preparations. J Infect Dis 1991; 163:882.
7. Roffi I, Mels G, Antonelli G, et al. Breakthrough during recombinant interferon alpha therapy in patients with chronic hepatitis C virus infection: prevalence, etiology, and management. Hepatology 1995; 21:645.
8. Reichen J, Bianchi L, Buhler H, et al. Fixed versus titrated interferon-α2B in chronic hepatitis C: a randomized controlled multicenter trial. J Hepatol 1996; 25:275.