Glucose ingestion attenuates interleukin-6 release from contracting skeletal muscle in humans

Journal of Physiology

Volumn 549, Issue 2, 2003, Pages 607-612

  Febbraio, Mark A ^a,b   Steensbert, Adam ^a   Keller, Charlotte ^a   Starkie, Rebecca L ^a,b   Nielsen, Henning B ^a   Krustrup, Peter ^a,c   Ott, Peter ^a   Secher, Niels H ^a   Pedersen, Bente K ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b RMIT UNIVERSITY   (Australia)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOHYDRATE; FATTY ACID; GLUCOSE; GLYCOGEN; INTERLEUKIN 6; MESSENGER RNA; PLACEBO;

ADULT; ARTICLE; BEVERAGE; BICYCLE ERGOMETRY; BLOOD SAMPLING; BRACHIAL ARTERY; CARBOHYDRATE INTAKE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOKINE RELEASE; FATTY ACID TRANSPORT; FEMORAL VEIN; FUNCTION TEST; GLUCOSE INTAKE; GLUCOSE TRANSPORT; GLYCOGEN MUSCLE LEVEL; HUMAN; HUMAN EXPERIMENT; LEG BLOOD FLOW; MALE; MUSCLE BIOPSY; MUSCLE CONTRACTION; MUSCLE EXERCISE; MUSCLE METABOLISM; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKELETAL MUSCLE; THERMODILUTION; CYCLING; EXERCISE; HEART RATE; HUMAN TISSUE; LIMB; LUNG GAS EXCHANGE; RESPIRATORY EXCHANGE RATIO;

EID: 0038510904     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.2003.042374     Document Type: Article

References (21)

1. Andersen P & Saltin B (1985). Maximal perfusion of skeletal muscle in man. J Physiol 366, 233-249.
2. Bishop NC, Gleeson M, Nicholas CW & Ali A (2002). Influence of carbohydrate supplementation on plasma cytokine and neutrophil degranulation response to high intensity intermittent exercise. Int J Sports Nutr Exerc Metab 12, 145-156.
3. Febbraio MA, Ott P, Nielsen HB, Steensberg A, Keller C, Krustrup P, Secher NH & Pedersen BK (2002). Exercise induces hepatosplanchnic release of heat shock protein 72 in humans. J Physiol 544, 957-962.
4. Febbraio MA, Ott P, Nielsen HB, Steensberg A, Keller C, Krustrup P, Secher NH & Pedersen BK (2003). Hepatosplanchnic clearance of interleukin-6 in humans. Am J Physiol (in the Press).
5. Febbraio MA & Pedersen BK (2002). Muscle derived interleukin-6, mechanisms for activation and possible biological roles. FASEB J 16, 1335-1347.
6. Jeukendrup AE & Jentjens R (2000). Oxidation of carbohydrate feedings during prolonged exercise: current thoughts, guidelines and directions for future research. Sports Med 29, 407-424.
7. Keller C, Steensberg A, Pilegaard H, Osada T, Saltin B, Pedersen BK & Neufer PD (2001). Transcriptional activation of the IL-6 gene in human contracting skeletal muscle: influence of muscle glycogen content. FASEB J 15, 2748-2750.
8. Langberg H, Olesen JL, Gemmer C & Kjær, M (2002). Substantial elevation of interleukin-6 concentration in peritendonous, but not muscle, following prolonged exercise. J Physiol 542, 985-990.
9. Lyngsø D, Simonsen L & Bülow J (2002). Interleukin-6 production in human subcutaneous abdominal adipose tissue: effect of exercise. J Physiol 543, 1033-1046.
10. Nehlsen-Cannarella SL, Fagoaga OR, Nieman DC, Henson DA, Butterworth DE, Schmitt RL, Bailey EM, Warren BJ, Utter A & Davis JM (1997). Carbohydrate and the cytokine response to 2.5 h of running. J Appl Physiol 82, 1662-1667.
11. Nieman DC, Davis JM, Henson DA, Walberg-Rankin J, Shute M, Dumke CL, Utter AC, Vinci DM, Carson JA, Brown A, Lee WJ, McAnulty SR & McAnulty LS (2003). Carbohydrate ingestion influences skeletal muscle cytokine mRNA and plasma cytokine levels after a 3-h run. J Appl Physiol 94, 1917-1925.
12. Nieman DC, Nehlsen-Cannarella SL, Fagoaga OR, Henson DA, Utter A, Davis JM, Williams F & Butterworth DE (1998). Influence of mode and carbohydrate on the cytokine response to heavy exertion. Med Sci Sports Exerc 30, 671-678.
13. Nybo L, Nielsen B, Pedersen BK, Møller K & Secher NH (2002). Interleukin-6 release from human brain during exercise. J Physiol 542, 991-995.
14. Ostrowski K, Rhode T, Zacho M, Asp S & Pedersen BK (1998). Evidence that interleukin-6 is produced in human skeletal muscle during prolonged running. J Physiol 508, 949-953.
15. Papanicolaou DA & Vgontzas AN (2000). Interleukin-6: the endocrine cytokine. J Clin Endocrinol Metab 85, 1331-1333.
16. Starkie RL, Arkinstall MJ, Koukoulas I, Hawley JA & Febbraio MA (2001a). Carbohydrate ingestion attenuates the increase in plasma interleukin-6, but not skeletal muscle interieukin-6 mRNA, during exercise in humans. J Physiol 533, 585-591.
17. Starkie RL, Rolland J, Angus DJ, Anderson MJ & Febbraio MA (2001b). Circulating monocytes are not the source of the elevations in plasma IL-6 and TNF-α levels after prolonged running. Am J Physiol Circ Physiol 280, C769-774.
18. Steensberg A, Febbraio MA, Osada T, Schjerling P, van Hall G, Saltin B & Pedersen BK (2001). Interleukin-6 production in contracting human skeletal muscle is influenced by pre-exercise muscle glycogen content. J Physiol 537, 633-639.
19. Steensberg A, Keller C, van Hall G, Osada T, Schjerling P, Pedersen BK, Saltin B & Febbraio MA (2002). Muscle glycogen content and glucose uptake during exercise in humans: influence of prior exercise and dietary manipulation. J Physiol 541, 273-281.
20. Steensberg A, van Hall G, Osada T, Sacchetti M, Saltin B & Pedersen BK (2000). Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6. J Physiol 529, 237-242.
21. van Hall G, Steensberg A, Sacchetti M, Fischer C, Keller C, Schjerling P, Hiscock N, Møller K, Saltin B, Febbraio MA & Pedersen BK (2003). Interleukin-6 stimulated lipolysis and fat oxidation in humans. J Clin Endocrinol Metab (in the Press).