Metabolism of SFZ-47 in chicken embryo by liquid chromatography-electrospray ion trap mass spectrometry

Acta Pharmacologica Sinica

Volumn 24, Issue 6, 2003, Pages 576-580+622

  Dong, Qing Guang ^c   Gu, Jing Kai ^c   Zhong, Da Fang ^a   Fawcett, J Paul ^b   Zhou, Hui ^c  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b UNIVERSITY OF OTAGO   (New Zealand)

^c NONE

Author keywords

Chicken embryo; Electrospray ionization mass spectrometry; Liquid chromatography; Metabolism; SFZ 47

Indexed keywords

3H 1,2 DIHYDRO 2 (4 METHYLPHENYLAMINO)METHYL 1 PYRROLIZINONE; 4 (3H 1,2 DIHYDRO 1 PYRROLIZINONE 2 METHYLAMINO)BENZOIC ACID; 4 (3H 1,2 DIHYDRO 1 PYRROLIZINONE 2 METHYLAMINO)BENZYL ALCOHOL; DRUG METABOLITE; GLUCURONIDE; PYRROLIZINE DERIVATIVE; SFZ 47; UNCLASSIFIED DRUG;

AMNION FLUID; ANIMAL TISSUE; ARTICLE; CHICK EMBRYO; CONTROLLED STUDY; DRUG METABOLISM; DRUG SYNTHESIS; EMBRYO; IN VITRO STUDY; INCUBATION TIME; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; SOLID PHASE EXTRACTION; ZYGOTE;

ANIMALS; CHICK EMBRYO; CHROMATOGRAPHY, LIQUID; PYRROLES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 0038509053     PISSN: 16714083     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Rodrigues AD. Use of in vitro human metabolism studies in drug development. Biochem Pharmacol 1994; 48: 2147-56.
2. Brian B, Sue K, Michael J, Lee M. The biosynthesis and induction of microsomal UDP-glucuronyltransferase in avian liver. Biochem Soc Trans 1984; 12: 50-3.
3. Hamilton JW, Denison MS, Bloom SE. Development of basal and induced aryl hydrocarbon (benzo[α]pyrene) hydroxylase activity in the chicken embryo in ovo. Proc Natl Acad Sci USA 1983; 80: 3372-6.
4. Nakai K, Ward AM, Gannon M, Rifkind AB. β-Naphthoflavone induction of a cytochrome P-450 arachidonic acid epoxygenase in chick embryo liver distinct from the aryl hydrocarbon hydroxylase and from phenobarbitalinduced arachidonate epoxygenase. J Biol Chem 1992; 267: 19503-12.
5. Rifkind AB, Kanetoshi A, Orlinick J, Capdevila JH, Lee C. Purification and biochemical characterization of two major cytochrome P-450 isoforms induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in chick embryo liver. J Biol Chem 1994; 269: 3387-96.
6. Neugebauer M. Biotransformation von Arzneistoffen im Huenerei-eine Alternative zum Tierversuch [dissertation]. Habilitationsschrift: Univ of Bonn; 1997.
7. Zhong DF, Jiang H, Gu JK, Zhou H. Identification of two major metabolites of SFZ-47 in rabbits using ESI ion trap mass spectrometry. J Shenyang Pharm Univ 1999; 16: 1-5.
8. Gu JK, Zhong DF, Guo JF, Zhou H, Shen JC. Identification of hydroxylated metabolites of SFZ-47, a novel anti-inflammatory and analgesic agent, and its conjugates in rabbits. Acta Pharm Sin 2000; 35: 181-4.
9. Gu JK, Chu DF, Zhong DF, Li Y, Zhou H, Shen JC. Studies on the electrospray ion trap mass spectra of SFZ-47 and its metabolites for a novel anti-inflammatory and analgesic agent. Chem J Chinese Univ 2002; 23: 207-9.
10. Dong QG, Gu JK, Zhong DF, Chu DF, Sun L. Isolation and identification of a major metabolite of SFZ-47 in the rabbit urine. Acta Pharm Sin 2002; 37: 141-3.
11. Gu JK, Zhong DF, Chen XY. Analysis of O-glucuronide conjugates in urine by electrospray ion trap mass spectrometry. Fresenius' J Anal Chem 1999; 365: 553-8.
12. McGurk KA, Remmel RP, Hosagrahara VP. Reactivity of mefenamic acid 1-O-acyl glucuronide with proteins in vitro and ex vivo. Drug Metab Dispos 1996; 24: 842-9.