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Only one example of the preparation of an enantiomerically pure Schiff base of 2-hydroxyacetophenones with chiral aminoalcohols have been published:
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Schiff bases from enantiomers of FHPC 1 with (S)-tert-leucinol were used as the ligands in vanadium-catalyzed sulfoxidation of thioethers with moderate enantioselectivity; Vetter, A. H.; Berkessel, A. Tetrahedron Lett. 1998, 39, 1741-1744. Several analogues Schiff-bases of 1 were also synthesized by C. Schulz, Ph.D. Dissertation, Braunschweig, 1999.
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