Time-dependent mechanical properties of polymeric coatings used in rupturable pulsatile release dosage forms

Drug Development and Industrial Pharmacy

Volumn 29, Issue 6, 2003, Pages 623-630

  Bussemer, T ^a   Peppas, N A ^b   Bodmeier, Roland ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b The University of Texas at Austin   (United States)

Author keywords

Ethyl cellulose; Eudragit RS; Hydroxypropyl methylcellulose; Mechanical properties; Polymeric films; Pulsatile release

Indexed keywords

CITRIC ACID TRIETHYL ESTER; ETHYL CELLULOSE; EUDRAGIT RS; HYDROXYPROPYLMETHYLCELLULOSE; METHYLCELLULOSE; POLYMER; SEBACIC ACID DIBUTYL ESTER;

ARTICLE; DRUG COATING; DRUG FORMULATION; PULSATILE DRUG RELEASE; TIME; WATER TRANSPORT;

ACRYLIC RESINS; CELLULOSE; CITRATES; DICARBOXYLIC ACIDS; DRUG DELIVERY SYSTEMS; MECHANICS; METHYLCELLULOSE; PULSATILE FLOW; TIME FACTORS; WATER;

EID: 0038493710     PISSN: 03639045     EISSN: None     Source Type: Journal    
DOI: 10.1081/DDC-120021311     Document Type: Article

References (18)

1. Ross, A.C.; Macrae, R.J.; Walther, M.; Stevens, H.N.E. Chronopharmaceutical drug delivery from a pulsatile capsule device based on programmable erosion. J. Pharm. Pharmacol. 2000, 52, 903-909.
2. Stevens, H.N.E.; Wilson, C.G.; Welling, P.G.; Bakhshaee, M.; Binns, J.S.; Perkins, A.C.; Frier, M.; Blackshaw, E.P.; Frame, M.W.; Nichols, D.J.; Humphrey, M.J.; Wicks, S.R. Evaluation of Pulsincap to provide regional delivery of dofetilide to the human GI tract. Int. J. Pharm. 2002, 236 (1-2), 27-34.
3. Peppas, N.A. Hydrogels and drug delivery. Curr. Opinion Coll. Interfac. Sci. 1997, 2, 531-537.
4. Bussemer, T.; Otto, I.; Bodmeier, R. Pulsatile drug-delivery systems. Crit. Rev. Ther. Drug Carrier Syst. 2001, 18 (5), 433-458.
5. Lemmer, B. Chronopharmacokinetics: implications for drug treatment. J. Pharm. Pharmacol. 1999, 51, 887-890.
6. Ritschel, W.A.; Forusz, H. Chronopharmacology: a review of drugs studies. Meth. Find. Exp. Clin. Pharmacol. 1994, 16 (1), 57-75.
7. Amidon, G.L.; Leesman, G.D. Pulsatile Drug Delivery System. US Patent 5,229,131, 1993.
8. Hjärtstam, J.; Hjertberg, T. Effect of hydroxyl group content in ethyl cellulose on permeability in free films and coated membranes. J. Appl. Polym. Sci. 1999, 72, 529-535.
9. Hyppölä, R.; Husson, I.; Sundholm, F. Evaluation of physical properties of plasticized ethyl cellulose films cast from ethanol solution. Part I. Int. J. Pharm. 1996, 133, 161-170.
10. Wu, C.; McGinity, J.W. Non-traditional plasticization of polymeric films. Int. J. Pharm. 1999, 177, 15-27.
11. Rowe, R.C. The cracking of film coatings on film-coated tablets - a theoretical approach with practical implications. J. Pharm. Pharmacol. 1981, 33, 423-426.
12. Rowe, R.C.; Roberts, R.J. The effect of some formulation variables on crack propagation in pigmented tablet film coatings using computer simulation. Int. J. Pharm. 1992, 86, 49-58.
13. Bodmeier, R.; Paeratakul, O. Dry and wet strength of polymeric films prepared from an aqueous colloidal polymer dispersion, Eudragit RS30D. Int. J. Pharm. 1993, 96, 129-138.
14. Tho, I.; Schultz, P.; Waaler, T.; Kleinebudde, P. Mechanical properties of dry and wet free polymer films. Proceed. Intern. Symp. Control. Rel. Bioact. Mater., Boston, USA, 1999.
15. Bodmeier, R.; Paeratakul, O. Mechanical properties of dry and wet cellulosic and acrylic films prepared from aqueous colloidal polymer dispersions used in the coating of solid dosage forms. Pharm. Res. 1994, 11 (6), 882-888.
16. Kuethe, D.O.; Augenstein, D.C.; Gresser, J.D.; Wise, D.L. Design of capsules that burst at predetermined times by dialysis. J. Contr. Rel 1992, 18, 159-164.
17. Radebaugh, G.W.; Murtha, J.L.; Julian, T.N.; Bondi, J.N. Methods for evaluating the puncture and shear properties of pharmaceutical polymeric films. Int. J. Pharm. 1988, 45, 39-46.
18. Nielsen, L.E.; Landel, R.F. Mechanical Properties of Polymers and Composites; Dekker: New York, 1994.