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Volumn 13, Issue 16, 2003, Pages 2667-2671

Suzuki cross-coupling approaches to the synthesis of bioactive 3-substituted and 5-substituted-4-methoxy-6-methyl-2-pyrones

Author keywords

[No Author keywords available]

Indexed keywords

PYRONE DERIVATIVE;

EID: 0038487718     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(03)00546-8     Document Type: Article
Times cited : (42)

References (28)
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    • (a) Bu'Lock J.D., Smith H.E. J. Chem. Soc. 1960;502 (b) Effenberger F., Ziegler T. Chem. Ber. 120:1987;1339 (c) Tam T.F., Coles P. Synthesis. 1988;383 (d) Moody C.J., Rahimtoola K.F. J. Chem. Soc., Perkin Trans. 1. 1990;673 (e) Moody C.J., Rahimtoola K.F. J. Chem. Soc., Perkin Trans. 1. 1990;681.
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    • (a) Lee J.-H., Kim W.-S., Lee Y.Y., Cho C.-G. Tetrahedron Lett. 43:2002;5779 (b) Lee J.-H., Park J.-S., Cho C.-G. Org. Lett. 4:2002;1171.
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    • 4) and concentrated in vacuo to give the crude product, which was purified by flash chromatography to give pale oils or solids
    • 4) and concentrated in vacuo to give the crude product, which was purified by flash chromatography to give pale oils or solids.
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    • See ref 3 for synthetic details of the 4-alkenyl-6-methyl-2-pyrone ring systems.
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    • 50 values against A2780 and K562 cell lines.
  • 27
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    • For complete assay procedures for the 2-pyrones, see: Marrison, L. R. PhD Thesis, 'The synthesis and antimicrobial activities of 2H-pyran-2-ones', (Chapter 5), Manchester Metropolitan University (UK), 1998; Dickinson, J. M. PhD Thesis, 'The chemistry of fungal biocontrol agents', University of Sussex (UK), 1988. These assays will be reported in full in due course
    • For complete assay procedures for the 2-pyrones, see: Marrison, L. R. PhD Thesis, 'The synthesis and antimicrobial activities of 2H-pyran-2-ones', (Chapter 5), Manchester Metropolitan University (UK), 1998; Dickinson, J. M. PhD Thesis, 'The chemistry of fungal biocontrol agents', University of Sussex (UK), 1988. These assays will be reported in full in due course.


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