Immune alterations in mice exposed to the herbicide simazine

Journal of Toxicology and Environmental Health - Part A

Volumn 66, Issue 12, 2003, Pages 1159-1173

  Kim, Kyung Ran ^a   Son, Eun Wha ^a   Hee Um, Sung ^a   Kim, Byung Oh ^a   Rhee, Dong Kwon ^a   Pyo, Suhkneung ^a  

^a Sungkyunkwan University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CONCANAVALIN A; GROUND WATER; HERBICIDE; IMMUNOGLOBULIN M; LIPOPOLYSACCHARIDE; SIMAZINE;

ACUTE TOXICITY; ANIMAL CELL; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; B LYMPHOCYTE ACTIVATION; CELL PROLIFERATION; ENVIRONMENTAL EXPOSURE; IMMUNE RESPONSE; IMMUNOMODULATION; MACROPHAGE ACTIVATION; MALE; MOUSE; NATURAL KILLER CELL; NONHUMAN; PERITONEUM MACROPHAGE; PLAQUE FORMING CELL; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; WATER POLLUTION;

ADMINISTRATION, ORAL; ANIMALS; ANTIBODY FORMATION; BODY WEIGHT; DOSE-RESPONSE RELATIONSHIP, DRUG; HERBICIDES; IMMUNE SYSTEM; KILLER CELLS, NATURAL; LYMPHOCYTE ACTIVATION; MACROPHAGES, PERITONEAL; MALE; MICE; MICE, INBRED C57BL; ORGAN SIZE; SIMAZINE; SPLEEN;

ANIMALIA; OVIS ARIES;

EID: 0038486734     PISSN: 15287394     EISSN: None     Source Type: Journal    
DOI: 10.1080/15287390306358     Document Type: Article

References (23)

1. Adams, D. O., and Hamilton, T. A. 1984. The cell biology of macrophage activation. Annu. Rev. Immunol. 2:283-318.
2. Barshtein, I. A., Palii, G. K., Persidskii, I. V., Ben'iaminov, V. O., and Pushkar, M. S. 1991. Immunomorphological analysis of prolonged intoxication by low doses of herbicide simazine. Bull. Exp. Biol. Med. 112:657-659.
3. Bogdanffy, M. S., O'Connor, J. C., Hansen, J. F., Gaddamidi, V., Van Pelt, C. S., Green, J. W., and Cook, J. C. 2000. Chronic toxicity and oncogenicity bioassay in rats with the chloro-s-triazine herbicide cyanazine. J. Toxicol. Environ. Health A 60:567-586.
4. Eldrige, J. C., Gleenor-Heyser, D. G., and Extrom, P. C. 1994. Short-term effects of chlorotriazines on estrus in female Sprague-Dawley and Fischer 344 rats. J. Toxicol. Environ. Health 43:155-167.
5. Flick, D. A., and Gifford, G. E. 1984. Comparison of in vitro cell cytotoxicity assays for tumor necrosis factor. J. Immunol. 68:167-175.
6. Fournier, M., Friborg, J., Girard, D., Mansour, S., and Krzytyniak, K. 1992. Limited immunotoxic potential of technical formulation of the herbicide atrazine (AAtrex) in mice. Toxicol. Lett. 60:263-274.
7. Golden, R., J., Noller, K. L., Titus-Ernstoff, L., Kaufman, R. H., Mittendorf, R., Stillman, R., and Reese, E.A. 1998. Environmental endocrine modulators and human health: An assessment of the biological evidence. Crit. Rev. Toxicol. 28:109-227.
8. Goldman, L. R. 1 994. Atrazine, simazine and cyazine: Notice of initiation of Special Review. Fed. Reg. 59:60412-60443.
9. Hanioka, N., Jinno, H., Tanaka-Kagawa, T., Nishimura, T., and Ando, M. 1999. In vitro metabolism of simazine, atrazine and propazine by hepatic cytochrome P450 enzymes of rat, mouse and guinea pig, and oestrogenic activity of chloro triazines and their main metabolites. Xenobiotica 29:1213-1226.
10. Hooghe, R. J., Devos, S., and Hooghe-Peters, E. L. 2000. Effects of selected herbicides on cytokine production in vitro. Life Sci. 66:2519-2525.
11. Institoris, L., Siroki, O., and Desi, I. 1995. Immunotoxicity study of repeated small doses of dimethoate and methylparathion administered to rats over three generations. Hum. Exp. Toxicol. 14:879-883.
12. Kim, K. R., Son, E. W., Rhee, D. K., and Pyo, S. 2002. The immunomodulatory effects of the herbicide simazine on murine macrophage functions in vitro. Toxicol. In Vitro 16:33-39.
13. Kligerman, A. D., Doerr, C. L., Tennant, A. H., and Peng, B. 2000. Cytogenetic studies of three triazine herbicides II. In vivo micronucleus studies in mouse bone marrow. Mutat. Res. 471:107-112.
14. Klostergaard, J. 1985. A rapid extremely sensitive, quantitative microassay for cytotoxic cytokines. Lymphokine Res. 4:309-317.
15. Moretta, L., Ciccone, E., Moretta, A., Hoglund, P., Ohelen, C., and Karre, K. 1992. Allorecognition by NK cells: Nonself or no self. Immunol. Today 13:300-306.
16. Mosmann, T. 1983. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J. Immunol. Methods 65:55-63.
17. Murink, M. R., and Nash, C. L. 1977. Mutagenicity of the triazine herbicide atrazine, cyazine, and simazine in Drosophila melanogaster. J. Toxicol. Environ. Health 3:691-687.
18. Pinter, A. G., Torok, M., Borzsonyi, A., Surjan, M., Csik, Z., and Kocsis, Z. 1990. Long-term carcinogenicity bioassay of the herbicide atrazine in F344 rats. Neoplasma 37:533-544.
19. Son, E. H., Moon, E. Y., Rhee, D. K., and Pyo, S. 2001. Stimulation of various functions in murine peritoneal macrophages by high mannuronic acid-containing alginate (HMA) exposure in vivo. Int. Immunopharmacol. 1:147-154.
20. Stevens, J. T., Breckenridge, C. B., Wetzel, L. T., Gillis, J. H., Luempert, L. G. III, and Eldridge, J. C. 1994. Hypothesis for mammary tumorigenesis in Sprague-Dawley rats exposed to certain triazine herbicides. J. Toxicol. Environ. Health 43:139-153
21. Stevens, J. T., Breckenridge, C. B., Wetzel, L., Thakur, A. K., Liu, C., Werner, C., Luempert, L. G. III, and Eldrige, J. C. 1999. A Risk characterization for atrazine: Oncogenicity profile. J. Toxicol. Environ. Health A 56:69-109.
22. Wetzel, L. T., Breckenridge, C. B., Gillis, J. H., Luempert, L. G. III, and Stevens J. T. 1994. Short-term effects of chlorotriazines on estrus in female Sprague-Dawley and Fischer 344 rats. J. Toxicol. Environ. Health 43:155-167.
23. Worthing, C. R., and Walker, S. B. 1983. The pesticide manual. Lavenham, UK: Lavenham Press.