Adverse effects of local anesthetic infiltration on wound healing

Regional Anesthesia and Pain Medicine

Volumn 28, Issue 3, 2003, Pages 233-240

  Brower, Marc C ^b   Johnson, Michael E ^a  

^a MAYO CLINIC   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BENZOCAINE; BUPIVACAINE; CINCHOCAINE; COCAINE; EMLA; LIDOCAINE; LOCAL ANESTHETIC AGENT; MEPIVACAINE; PRILOCAINE; PROCAINE; PROXYMETACAINE; TETRACAINE;

COLLAGEN SYNTHESIS; DNA SYNTHESIS; DRUG SAFETY; GRANULATION TISSUE; HUMAN; INFLAMMATION; LOCAL ANESTHESIA; NONHUMAN; PRIORITY JOURNAL; REVIEW; TISSUE REGENERATION; WOUND CONTRACTION; WOUND HEALING; WOUND HEALING IMPAIRMENT;

EID: 0038486173     PISSN: 10987339     EISSN: None     Source Type: Journal    
DOI: 10.1053/rapm.2003.50050     Document Type: Review

References (48)

1. Renck H. Wound infiltration with local anaesthetics. Acta Anaesthesiol Scand 1994;38:2-6.
2. Rowlingson JC. How can local anesthetic in the wound not help? Anesth Analg 2001;92:3-4.
3. Dahl V, Raeder JC. Non-opioid postoperative analgesia. Acta Anaesthesiologica Scand 2000;44:1191-1203.
4. Dahl JB, Moiniche S, Kehlet H. Wound infiltration with local anaesthetics for postoperative pain relief [review]. Acta Anaesthesiol Scand 1994;38:7-14.
5. Fredman B, Shapiro A, Zohar E, Feldman E, Shorer S, Rawal N, Jedeikin R. The analgesic efficacy of patient-controlled ropivacaine instillation after cesarean delivery. Anesth Analg 2000;91:1436-1440.
6. Angood PB, Gingalewski CA, Andersen DK. Surgical complications. In: Townsend CM Jr, ed. Sabiston Textbook of Surgery: The Biological Basis of Modern Surgical Practice,. 16th ed. Philadelphia, PA: Saunders; 2001: 198-225.
7. Hansson C, Holm J, Lillieborg S, Syren A. Repeated treatment with lidocaine/prilocaine cream (EMLA) as a topical anaesthetic for the cleansing of venous leg ulcers. A controlled study. Acta Derm Venereol 1993; 73:231-233.
8. Clark RAF. Wound repair: Overview and general considerations. In: Clark RAF, ed. The Molecular and Cellular Biology of Wound Repair. 2nd ed. New York, NY: Plenum; 1996:3-50.
9. Hogan Q, Dotson R, Erickson S, Kettler R, Hogan K. Local anesthetic myotoxicity: A case and review. Anesthesiology 1994;80:942-947.
10. Flatmark AL. The effect of local anaesthetics on the tensile strength of healing fractures. An experimental study in the rabbit. Acta Chir Scand 1967;133:605-607.
11. Gnuechtel MM, Schenk LL, Postma GN. Late effects of topical anesthetics on the healing of guinea pig tympanic membranes after myringotomy. Arch Otolaryngol Head Neck Surg 2000;126:733-735.
12. Powell DM, Rodeheaver GT, Foresman PA, Hankins CL, Bellian KT, Zimmer CA, Becker DG, Edlich RF. Damage to tissue defenses by EMLA cream. J Emerg Med 1991;9:205-209.
13. Martin GR, Peacock EE Jr. Current perspectives in wound healing. In: Cohen IK, Diegelmann RF, Lindblad WJ, ed. Wound Healing: Biochemical and Clinical Aspects. Philadelphia, PA: Saunders; 1992:1-4.
14. Hollmann MW, Durieux ME. Local anesthetics and the inflammatory response: A new therapeutic indication? Anesthesiology 2000;93:858-875.
15. MacGregor RR, Thorner RE, Wright DM. Lidocaine inhibits granulocyte adherence and prevents granulocyte delivery to inflammatory sites. Blood 1980;56: 203-209.
16. Rimbäck G, Cassuto J, Wallin G, Westlander G. Inhibition of peritonitis by amide local anesthetics. Anesthesiology 1988;69:881-886.
17. Pigeolet E, Raes M, Houbion A, Remacle J. Effect of procaine on cultivated human WI-38 fibroblasts. Exp Gerontol 1988;23:87-96.
18. Moreira LB, Kasetsuwan N, Sanchez D, Shah SS, LaBree L, McDonnell PJ. Toxicity of topical anesthetic agents to human keratocytes. J Cataract Refract Surg 1999;25:975-980.
19. Johnson ME, Uhl CB, Choi H, Capecchi J. Lidocaine is toxic in a cell culture model of wound healing. Reg Anesth Pain Med 2000;25: 27 (Suppl).
20. Eichhorn JH, Peterkofsky B. Local anesthetic-induced inhibition of collagen secretion in cultured cells under conditions where microtubules are not depolymerized by these agents. J Cell Biol 1979;81: 26-42.
21. Pierzchalska M, Michalik M, Stepien E, Korohoda W. Changes in morphology of human skin fibroblasts induced by local anaesthetics: Role of actomyosin contraction. Eur J Pharmacol 1998;358:235-244.
22. Schultz E, Lipton BH. The effect of marcaine on muscle and non-muscle cells in vitro. Anat Rec 1978; 191:351-369.
23. Sturrock JE, Nunn JF. Cytotoxic effects of procaine, lignocaine and bupivacaine. Br J Anaesth 1979;51: 273-280.
24. Chvapil M, Hameroff SR, O'Dea K, Peacock EE Jr. Local anesthetics and wound healing. J Surg Res 1979;27:367-371.
25. Johnson RB, Dowse CM. Comparative effects of local anesthetic preparations on gingival fibroblasts of the rat. J Dent Res 1986;65:1125-1132.
26. Dass BA, Soong HK, Lee B. Effects of proparacaine on actin cytoskeleton of corneal epithelium. J Ocul Pharmacol Ther 1988;4:187-194.
27. Bisla K, Tanelian DL. Concentration-dependent effects of lidocaine on corneal epithelial wound healing. Invest Ophthalmol Vis Sci 1992;33:3029-3033.
28. Gold MS, Reichling DB, Hampl KF, Drasner K, Levine JD. Lidocaine toxicity in primary afferent neurons from the rat. J Pharmacol Exp Ther 1998;285: 413-421.
29. Johnson ME, Saenz JA, DaSilva AD, Uhl CB, Gores GJ. Effect of local anesthetic on neuronal cytoplasmic calcium and plasma membrane lysis (necrosis) in a cell culture model. Anesthesiology 2002;97:1466-1476.
30. Kagan HM. Intra- and extracellular enzymes of collagen biosynthesis as biological and chemical targets in the control of fibrosis [review]. Acta Tropica 2000; 77:147-152.
31. Schaffer CJ, Nanney LB. Cell biology of wound healing [review]. Int Rev Cytol 1996;169:151-181.
32. Salcido R. Enzymatic debridement: A tried and tested method. Adv Skin Wound Care 2000;13:92.
33. Murray JC, Pinnell SR. Keloids and excessive dermal scarring. In: Cohen IK, Diegelmann RF, Lindblad WJ, ed. Wound Healing: Biochemical & ClinicalAaspects. Philadelphia, PA: Saunders; 1992:500-509.
34. Nishina K, Mikawa K, Morikawa O, Obara H, Mason RJ. The effects of intravenous anesthetics and lidocaine on proliferation of cultured type ii pneumocytes and lung fibroblasts. Anesth Analg 2002;94:385-388.
35. Morris T, Tracey J. Lignocaine: Its effects on wound healing. Br J Surg 1977;64:902-903.
36. Morris T, Appleby R. Retardation of wound healing by procaine. Br J Surg 1980;67:391-392.
37. Vasseur PB, Paul HA, Dybdal N, Crumley L. Effects of local anesthetics on healing of abdominal wounds in rabbits. Am J Vet Res 1984;45:2385-2388.
38. Davies B, Guyuron B, Husami T. The role of lidocaine, epinephrine, and flap elevation in wound healing after chemical peel. Ann Plast Surg 1991;26: 273-278.
39. Madhuchandra SP, Bhat MP, Ramesh KV. Wound healing profile of topical xylocaine preparations in rodents. Indian J Exp Biol 1991;29:877-878.
40. Drucker M, Cardenas E, Arizti P, Valenzuela A, Gamboa A. Experimental studies on the effect of lidocaine on wound healing. World J Surg 1998;22:394-397.
41. Liu JC, Steinemann TL, McDonald MB, Thompson HW, Beuerman RW. Topical bupivacaine and proparacaine: A comparison of toxicity, onset of action, and duration of action. Cornea 1993;12:228-232.
42. Sun R, Hamilton RC, Gimbel HV. Comparison of 4 topical anesthetic agents for effect and corneal toxicity in rabbits. J Cataract Refract Surg 1999;25:1232-1236.
43. Oikarinen K, Oikarinen A. Periodontal ligament (PDL) anaesthesia. The effect of anaesthetics on total protein and collagen synthesis by PDL fibroblasts. Proc Finn Dent Soc 1988;84:201-204.
44. Martinsson T, Haegerstrand A, Dalsgaard CJ. Ropivacaine and lidocaine inhibit proliferation of non-transformed cultured adult human fibroblasts, endothelial cells and keratinocytes. Agents Actions 1993;40:78-85.
45. Akhtar S, Podgoreanu M. PDGF-induced DNA synthesis in human lung fibroblast is inhibited by lidocaine. Anesthesiology 2001; 95:A-917 (ASA Suppl).
46. Raizada MK, Fellows RE. Alteration of insulin binding and cytoskeletal organization in cultured fibroblasts by tertiary amine local anesthetics. J Supramol Struct 1979;11:547-561.
47. Mehendale F, Martin P. The cellular and molecular events of wound healing. In: Falanga V, ed. Cutaneous Wound Healing. London, UK: Martin Dunitz; 2001: 15-37.
48. Yamaguchi Y, Yoshikawa K. Cutaneous wound healing: An update [review]. J Dermatol 2001;28:521-534.