Herba houttuyniae extract induces apoptotic death of human promyelocytic leukemia cells via caspase activation accompanied by dissipation of mitochondrial membrane potential and cytochrome c release

Experimental and Molecular Medicine

Volumn 35, Issue 2, 2003, Pages 91-97

  Kwon, Kang Beom ^a   Kim, Eun Kyung ^a   Shin, Byung Cheul ^a   Seo, Eun A ^a   Yang, Jeong Yeh ^b   Ryu, Do Gon ^a  

^a Wonkwang University   (South Korea)

^b Chonbuk National University   (South Korea)

Author keywords

Apoptosis; Cancer; Caspase; Medicine, herbal; Mitochondria; Phytotherapy

Indexed keywords

CASPASE; CASPASE 3; CASPASE 3 INHIBITOR; CASPASE 9; CYCLOSPORIN A; CYTOCHROME C; DNA FRAGMENT; HERBA HOUTTUYNIAE EXTRACT; N ACETYLASPARTYLGLUTAMYLVALYLASPARTALDEHYDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PLANT EXTRACT; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL STRAIN HL 60; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME RELEASE; HERBAL MEDICINE; HUMAN; HUMAN CELL; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; PROMYELOCYTIC LEUKEMIA; SIGNAL TRANSDUCTION;

EID: 0038485712     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.1038/emm.2003.13     Document Type: Article

References (29)

1. Bae WY, Go HG, Kim CH. Experimental study on the effect of Houttuyniae Herbal Accupuncture on the growth of melanoma B16 in mice. J Korean Acupunture & Moxibustion Society 2001;18:186-201
2. Bold RJ, Termuhlen PM, McConkey DJ. Apoptosis, cancer and cancer therapy. Surg Oncol 1997;6:133-42
3. Bossy-Wetzel E, Green DR. Caspases induce cytochrome c release from mitochondria by activating cytosolic factors. J Biol Chem 1999;274:17484-90
4. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248-54
5. Enari M, Sakahira H, Yokoyama H, Okawa K, Iwamatsu A, Nagata S. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature 1998;391: 43-50
6. Green DR, Reed JC. Mitochondria and apoptosis. Science 1998;281:1309-12
7. Hall AG. Review: The role of glutathione in the regulation of apoptosis. Eur J Clin Invest 1999;29:238-45
8. Ikezoe T, Chen SS, Heber D, Taguchi H, Koeffier HP. Baicalin is a major component of PC-SPES which inhibits the proliferation of human cancer cells via apoptosis and cell cycle arrest. Prostate 2001;49:285-92
9. Jung HW, Choi JH, Jin CS. Effects of flos lonicerae and herba houttuyniae on human cancer cell-lines. Korean J Oriental Medical Pathology 1996;10:126-32
10. Kamesaki H. Mechanisms involved in chemotherapy-induced apoptosis and their implications in cancer chemotherapy. Int J Hematol 1998;68:29-43
11. Kaufmann SH, Desnoyers S, Ottaviano Y, Davidson NE, Poirier GG. Specific proteolytic cleavage of poly (ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis. Cancer Res 1993;53:3976-85
12. Kelloff GJ, Crowell JA, Steele VE, Lubet RA, Malone WA, Boone CW, Kopelovich L, Hawk ET, Lieberman R, Lawrence JA, Ali I, Viner JL, Sigman CC. Progress in cancer chemoprevention: development of diet-derived chemopreventive agents. J Nutr 2000;130:467S-71S
13. Krippner A, Matsuno-Yagi A, Gottlieb RA, Babior BM. Loss of function of cytochrome c in Jurkat cells undergoing fasmediated apoptosis. J Biol Chem 1996;271:21629-36
14. Kroemer G, Reed JC. Mitochondrial control of cell death. Nat Med 2000;6:513-9
15. Kwon KB, Yang JY, Ryu DG, Rho HW, Kim JS, Park JW, Kim HR, Park BH. Vibrio vulnificus cytolysin induces superoxide anion-initiated apoptotic signaling pathway in human ECV304 cells. J Biol Chem 2001;276:47518-23
16. Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES, Wang X. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 1997;91:479-89
17. Liu X, Li P, Widlak P, Zou H, Luo X, Garrard WT, Wang X. The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis. Proc Natl Acad Sci USA 1998;95:8461-6
18. Marchetti P, Castedo M, Susin SA, Zamzami N, Hirsch T, Macho A, Haeffner A, Hirsch F, Geuskens M, Kroemer G. Mitochondrial permeability transition is a central coordinating event of apoptosis. J Exp Med 1996;184:1155-60
19. Marks L, DiPaola R, Nelson P, Chen S, Heber D, Belldegrun A, Lowe F, Fan J, Leaders F, Pantuck A, Tyler V. PC-SPES: herbal formulation for prostate cancer. Urology 2002;60:369
20. Mukhtar H, Ahmad N. Green tea in chemoprevention of cancer. Toxicol Sci 1999;52:111-7
21. Oez S, Platzer E, Welte K. A quantitative colorimetric method to evaluate the functional state of human polymorphonuclear leukocytes. Blut 1990;60:97-102
22. Rho BG. Studies on the antiallergic reactions of the herba houttuyniae. Korean J Herbol 1998;13:77-89
23. Riss TL. Apoptosis as a biomarker in chemoprevention trials. Urology 2001;57:141-2
24. Setiawan VW, Zhang ZF, Yu GP, Lu QY, Li YL, Lu ML, Wang MR, Guo CH, Yu SZ, Kurtz RC, Hsieh CC. Protective effect of green tea on the risks of chronic gastritis and stomach cancer. Int J Cancer 2001;92:600-4
25. Shi Y. Mechanisms of caspase activation and inhibition during apoptosis. Mol Cell 2002;9:459-70
26. Sporn MB, Suh N. Chemoprevention of cancer. Carcinogenesis 2000;21:525-30
27. Susin SA, Zamzami N, Kroemer G. Mitochondria as regulators of apoptosis: doubt no more. Biochim Biophys Acta 1998;1366:151-65
28. Vayssiere JL, Petit PX, Risler Y, Mignotte B. Commitment to apoptosis is associated with changes in mitochondrial biogenesis and activity in cell lines conditionally immortalized with simian virus 40. Proc Natl Acad Sci USA 1994;91: 11752-6
29. Wyllie AH, Kerr JF, Currie AR. Cell death: the significance of apoptosis. Int Rev Cytol 1980;68:251-306