Synthesis of novel carbosilane dendrimers with myo-inositol cores

Chinese Chemical Letters

Volumn 14, Issue 5, 2003, Pages 465-467

  Yu, Zhi Jun ^a   Zhang, Qi Zhen ^a   Zhou, Qi Feng ^b  

^a SHANDONG UNIVERSITY   (China)

^b PEKING UNIVERSITY   (China)

Author keywords

Carbosilane dendrimer; Divergent method; Grignard reagent; Hydrosilylation; Myo inositol

Indexed keywords

DENDRIMER; INOSITOL; SILANE DERIVATIVE;

ARTICLE; HYDROSILYLATION; SYNTHESIS;

EID: 0038458771     PISSN: 10018417     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. P. Busson, H. Ihre, A. Hult, J. Am. Chem. Soc., 1998, 120 (35), 9070.
2. J. Majoral, A. Caminade, Chem. Rev., 1999, 99 (3), 845.
3. C. Kim, Y. Jeong, I. Jung, J. Org. Chem., 1998, 570, 9.
4. C. Blum-Held, P. Bernard, G. Schlewer, J. Am. Chem. Soc., 2001, 123 (43), 10788.
5. General hydrosilylation procedure: 0G or 1G or 2G and methyldichlorosilane (approximately 1.5 molar equiv relative to the number of double bonds) were dissolved in THF, then 4 drops of Karstedt catalyst were added, the resulting solution was stirred under nitrogen at 50°C for 12 hours. All volatiles were then removed under reduced pressure, and the corresponding hydrosilylated product was obtained as thick colorless oil.
6. 4. Volatiles were removed on the rotary evaporator, the residue was chromatographed on silica gel using hexane/EtOAc as eluent, and the target dendrimer was obtained as colorless oil.
7. 6: C, 67.28; H, 10.27. Found: C, 67.02; H, 10.18. Mol wt (VPO): 1125 (calcd 1178).
8. 18: C, 66.89; H, 10.78; Found: C, 66.75; H, 10.72. Mol wt (VPO): 2772 (calcd 2693).
9. 42: C, 66.73; H,10.99; Found: C, 66.75; H, 10.72. Mol wt (VPO): 5631 (calcd 5724).