Evaluation of tricyclic antidepressant false positivity in a pediatric case of cyproheptadine (periactin) overdose

Therapeutic Drug Monitoring

Volumn 25, Issue 3, 2003, Pages 299-304

  Yuan, Constance M ^a   Spandorfer, Phillip R ^b   Miller, Samuel L ^a   Henretig, Fred M ^b   Shaw, Leslie M ^a  

^a HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMITRIPTYLINE; CYPROHEPTADINE; DESIPRAMINE; DOXEPIN; IMIPRAMINE; NORDOXEPIN; NORTRIPTYLINE; TRICYCLIC ANTIDEPRESSANT AGENT; TRIMIPRAMINE;

ARTICLE; BLOOD SAMPLING; CASE REPORT; CHILD; DIAGNOSTIC ERROR; DRUG CROSS REACTIVITY; DRUG OVERDOSE; DRUG SCREENING; ENZYME MULTIPLIED IMMUNOASSAY TECHNIQUE; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LABORATORY DIAGNOSIS; METABOLITE; PRIORITY JOURNAL; SCREENING TEST; TOXICITY TESTING;

ANTIDEPRESSIVE AGENTS, TRICYCLIC; CHILD, PRESCHOOL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYPROHEPTADINE; EVALUATION STUDIES; FALSE POSITIVE REACTIONS; FEMALE; HUMANS; OVERDOSE;

EID: 0038442750     PISSN: 01634356     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007691-200306000-00009     Document Type: Article

References (8)

1. Rainey, PM. Laboratory Principles and Techniques for Evaluation of the Poisoned or Overdosed Patient. In: Goldfrank LR, Flomenbaum NE, Lewin NA, et al, eds. Goldfrank's Toxicologic Emergencies. 7th ed. New York: McGraw-Hill; 2002:69-93.
2. Tasset, JJ, Schroeder, TJ, Pesce, AJ. Cyclobenzaprine overdose: the importance of a clinical history in analytical toxicology. J Anal Toxicol. 1986;10:258.
3. Matos, ME, Burns, MM, Shannon, MW. False-positive tricyclic antidepressant drug screen results leading to the diagnosis of carbamazepine intoxication. Pediatrics. 2000;105:e661-e663
4. Wians FH Jr. Norton JT. Wirebaugh SR. False-positive serum tricyclic antidepressant screen with cyproheptadine. Clin Chem. 1993;39:1355-1356.
5. Remaley AT, Hicks DG, Kane MD, Shaw LM. Laboratory assessment of poisoning with a carbamate insecticide. Clin Chem 1988;34:1933-1936.
6. Benzodiazepines and tricyclic antidepressants by HPLC [manual]. Hercules: Bio-Rad Laboratories; 1996.
7. Blaustein BS, Gaeta TJ, Balentine JR, et al. Cyproheptadineinduced central anticholinergic syndrome in a child: a case report. Pediatr Emerg Care. 1995;11:235-237.
8. Baehr GR, Romano M, Young JM. An unusual case of cyproheptadine (Periactin) overdose in an adolescent female. Pediatr Emerg Care. 1986;2:183-185.