Grapefruit juice inhibits 11β-hydroxysteroid dehydrogenase in vivo, in man [2]

Clinical Endocrinology

Volumn 59, Issue 1, 2003, Pages 143-144

  Palermo, Mario ^a   Armanini, Decio ^b   Delitala, Giuseppe ^a  

^a UNIVERSITY OF SASSARI   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; AURANTIIN; BIOFLAVONOID; NARINGENIN;

ADULT; APPARENT MINERALOCORTICOID EXCESS SYNDROME; CASE REPORT; DIAGNOSTIC IMAGING; DIAGNOSTIC PROCEDURE; DIET RESTRICTION; DIETARY INTAKE; ENZYME ACTIVITY; ENZYME INHIBITION; GENE MUTATION; GENETIC ANALYSIS; GENETIC DISORDER; GRAPEFRUIT JUICE; HUMAN; IN VIVO STUDY; INHIBITION KINETICS; LABORATORY TEST; LETTER; LIFESTYLE; MALE; PERIPHERAL EDEMA; PRIORITY JOURNAL; WEIGHT GAIN;

11-BETA-HYDROXYSTEROID DEHYDROGENASES; ADULT; ALDOSTERONE; BEVERAGES; CITRUS PARADISI; DEPRESSION, CHEMICAL; EDEMA; FEMALE; FOOD-DRUG INTERACTIONS; HUMANS; HYDROXYSTEROID DEHYDROGENASES; MINERALOCORTICOIDS; POTASSIUM; RENIN;

EID: 0038434528     PISSN: 03000664     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2265.2003.01806.x     Document Type: Letter

References (9)

1. Albistom, A.L., Obeyesekere, V.R., Smith, R.E. & Krozowsky, Z.S. (1994) Cloning and tissue distribution of the human 11β-hydroxysteroid dehydrogenase type 2 enzyme. Steroids, 59, 100-104.
2. Lee, Y.S., Lorenzo, B.J., Koufis, T. & Reidenberg, M.M. (1996) Grapefruit juice and its flavonoids inhibit 11β-hydroxysteroid dehydrogenase. Clinical Pharmacological Therapy, 59, 62-71.
3. Li, A., Tedde, R., Krozowsky, Z.S., Pala, A., Li, K.X., Shackleton, C.H.L., Mantero, F., Palermo, M. & Stewart, P.M. (1998) Molecular basis for hypertension in the type II variant of apparent mineralocorticoid excess syndrome. American Journal of Human Genetics, 63, 370-379.
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