Polychlorinated biphenyls and organochlorine pesticides are eliminated from therapeutic Factor VIII and immunoglobulin concentrates and reduced in albumin by plasma fractionation

Vox Sanguinis

Volumn 83, Issue 1, 2002, Pages 23-28

  Covaci, Adrian ^a   Laub, R ^b   Di Giambattista, M ^b   Branckaert, T ^b   Hougardy, V ^b   Schepens, P ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b Central Fractionation Department   (Belgium)

Author keywords

Albumin; Factor VIII; Immunoglobulins; PCBs; Plasma fractionation; Pollutants

Indexed keywords

ALBUMIN; BLOOD CLOTTING FACTOR 8 CONCENTRATE; CHOLESTEROL; IMMUNOGLOBULIN; ORGANOCHLORINE PESTICIDE; POLYCHLORINATED BIPHENYL DERIVATIVE; PROTEIN; TRIACYLGLYCEROL;

ADULT; ARTICLE; BLOOD LEVEL; CRYOPRECIPITATE; FRACTIONATION; HUMAN; MEASUREMENT; NORMAL HUMAN; PLASMA; POLLUTANT; PRIORITY JOURNAL; PROCESSING; TECHNIQUE;

ADOLESCENT; ADULT; AGED; CHEMICAL FRACTIONATION; ENVIRONMENTAL POLLUTANTS; FACTOR VIII; HUMANS; IMMUNOGLOBULINS, INTRAVENOUS; INSECTICIDES; MIDDLE AGED; PLASMA; POLYCHLORINATED BIPHENYLS; SERUM ALBUMIN;

EID: 0038418276     PISSN: 00429007     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1423-0410.2002.00168.x     Document Type: Article

References (18)

1. De Voogt P, Weels DE, Reutergardh L, Brinkman UATh: Biological activity, determination and occurrence of planar, mono- and diortho PCBs. Intern J Environ Anal Chem 1990; 40:1-46
2. Hong CS, Xiao J, Bush B, Shaw SD: Environmental occurrence and potential toxicity of planar, mono-, and di-ortho PCBs in the biota. Chemosphere 1998; 36:1637-1651
3. Geyer H, Scheunert I, Korte F: Bioconcentration potential of organic environmental chemicals in humans. Regul Toxicol Pharmacol 1986; 6:313-347
4. Jones KC: Determination of PCBs in human foodstuffs and tissues: suggestions for a selective congener analytical approach. Sci Total Environ 1998; 68:141-159
5. Pauwels A, Covaci A, Weyler J, Delbeke L, Dhont M, De Sutter P, D'Hooghe T, Schepens P: Comparison of POPs residues in serum and adipose tissue in a female population in Belgium, 1996-98. Arch Environ Contam Toxicol 2000; 39:265-270
6. Noren K, Weistrand C, Karpe F: Distribution of PCB congeners, DDE, HCB and Methylsulfonyl metabolites of PCB and DDE among various fractions of human blood plasma. Arch Environ Contam Toxicol 1999; 37:408-414
7. Covaci A, Koppen G, Van Cleuvenbergen R, Schepens P, Winneke G, van Larebeke N, Nelen V, Vlietinck R, Schoeters G: Persistent organochlorine pollutants in human serum of 50-65 year-old women in the Flanders Environmental and Health Study (FLEHS). Chemosphere 2002, in press
8. Cohn EJ, Strong LE, Hughes WL, Mulford DJ, Ashworth JN, Melin M, Taylor HL: Preparation and properties of serum and plasma proteins. IV. A system for the separation into fractions of the protein and lipoprotein components of biological tissues and fluids. J Am Chem Soc 1946; 68:459-475
9. Vanpoucke I, Willems J: Proceedings of the workshop on possible health implications of the dioxin crisis. Verh K Acad Geneeskd Belg 2000; 62:81-102
10. Larebeke N, Hens L, Schepens P, Covaci A, Baeyens J, Everaert K, Bernheim JL, Vlietinck R, De Poorter G: The Belgian PCB/dioxin incident of January-June 1999: exposure data and potential impact on health. Environ Health Perspect 2001; 109:265-273
11. Phillips DL, Pirlde JL, Burse VW, Bernert JT, Henderson LO, Needham LL: Chlorinated hydrocarbon levels in human serum: effects of fasting and feeding. Arch Environ Contam Toxicol 1989; 18:495-500
12. Covaci A, Pauwels A, Schepens P: Determination of selected POPs in human serum by SPE and GC-ECD. Intern J Environ Anal Chem 2000; 76:167-178
13. Covaci A, Schepens P: Improved determination of selected POPs in human serum by solid phase disk extraction and GC-MS. Chemosphere 2001; 43:439-447
14. Anon: Evaluation of the 23rd intercomparison study on organochlorine pollutants in human serum. Erlangen, University of Erlangen, 2000
15. Voorspoels S, Covaci A, Maervoet J, Schepens P. Relationships between age and levels of organochlorine pollutants in human serum of a Belgian population. Bull Environ Contam Toxicol 2002, in press
16. Staessen JA, Nawrot T, Den Hond E, Thijs L, Fagard R, Hoppenbrouwers K, Koppen G, Nelen V, Schoeters G, Vanderschueren D, Van Hecke E, Verschaeve L, Vlietinck R, Roels HA: Renal function, cytogenetic measurements, and sexual development in adolescents in relation to environmental pollutants: a feasibility study of biomarkers. The Lancet 2001; 357:1660-1669
17. GomezCatalan J, ToFigueras J: Transport of organochlorine residues in the rat and human blood. Arch Environ Contam Toxicol 1991; 20:61-66
18. European Commission, Health and Consumer Protection Directorate-General: Assessment of Dietary Intake of Dioxins and Related PCBs by the Population of EU Member States. Report on tasks for scientific cooperation. Report of experts participating in Task 3-2-5, 7 June 2000. http://www.europe.eu.int/comm/dgs/health_consumer/library/pub/pub08_en.pdf