Anti-HSV-1 activity of synthetic humic acid-like polymers derived from p-diphenolic starting com-pounds

Antiviral Chemistry and Chemotherapy

Volumn 13, Issue 4, 2002, Pages 241-249

  Klocking R ^a   Helbig, B ^a   Schotz G ^a   Schacke, M ^a   Wutzler, P ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

FT IR spectra; Herpes simplex virus type 1; Humic acid like polymers; p diphenolic compounds; Structure activity relationship

Indexed keywords

2 METHOXYHYDROQUINONE; 2,3 DIMETHYLHYDROQUINONE; 2,5 DIHYDROXYBENZALDEHYDE; 2,5 DIHYDROXYBENZOQUINONE; BENZALDEHYDE DERIVATIVE; BENZOQUINONE DERIVATIVE; CARBOXYL GROUP; GENTISIC ACID; HOMOGENTISIC ACID; HUMIC ACID; HYDROQUINONE DERIVATIVE; HYDROQUINONESULFONIC ACID; HYDROXYL GROUP; METHYLHYDROQUINONE; PHENOL DERIVATIVE; POLYMER; TETRAZOLIUM; TOLUENE DERIVATIVE; TRIMETHYLHYDROQUINONE; UNCLASSIFIED DRUG; ANTIVIRUS AGENT;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG SCREENING; DRUG SYNTHESIS; HERPES SIMPLEX; HERPES SIMPLEX VIRUS 1; INFRARED SPECTROSCOPY; MOLECULAR WEIGHT; NONHUMAN; OXIDATION; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; VIRUS INHIBITION; ANIMAL; CERCOPITHECUS; CHEMISTRY; DOSE RESPONSE; DRUG EFFECT; GROWTH, DEVELOPMENT AND AGING; HUMAN; HUMIC SUBSTANCE; LD 50; OXIDATION REDUCTION REACTION; VERO CELL; VIROLOGY; VIRUS CULTURE;

ANIMALS; ANTIVIRAL AGENTS; CERCOPITHECUS AETHIOPS; DOSE-RESPONSE RELATIONSHIP, DRUG; HERPESVIRUS 1, HUMAN; HUMANS; HUMIC SUBSTANCES; LETHAL DOSE 50; MOLECULAR WEIGHT; OXIDATION-REDUCTION; PHENOLS; PLAQUE ASSAY; POLYMERS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; STRUCTURE-ACTIVITY RELATIONSHIP; VERO CELLS;

EID: 0038411289     PISSN: 09563202     EISSN: None     Source Type: Journal    
DOI: 10.1177/095632020201300405     Document Type: Article

References (22)

1. Bellamy IJ (1980) The Infared Spectra of Complex Molecules, 2nd edn; vol. 2. Advances in Infrared Group Frequencies. London, New York: Chapman & Hall.
2. Benda R, Petrovic S & Rychterova V (1972) Transmission of herpesvirus along the trigeminal nerve in rabbit. Acta virologica 16:459-465.
3. Cataldo F (1998) On the structure of macromolecules obtained by oxidative polymerisation of polyhydroxyphenols and quinones. Polymer International 46:263-268.
4. Hadzija O & Spoljar B (1995) Quantitative determination of carboxylate by infrared spectroscopy application to humic acids. Fresenis' Journal of Analytical Chemistry 351:692-693.
5. Hänninen KI, Klöcking R & Helbig B (1987) Synthesis and characterization of humic acid-like polymers. Science of the Total Environment 62:201-210.
6. Hänninen KI, Klöcking R & Helbig B (1989) Structural studies on phenolic polymers derived from pyrogallol oxidation. Suomen Akatemian Julkaisuja 5:141-144.
7. Helbig B & Klöcking R (1983) Darstellung und Charakterisierung von Huminsäure-Modellsubsranzen. Zeitshrift für Physiotherapie 33:31-37.
8. Helbig B, Klöcking R & Wutzler P (1997) Anti-herpes simplex virus type 1 activity of humic acid-like polymers and their o-diphenolic starting compounds. Antiviral Chemistry & Chemotherapy 8:265-273.
9. Helbig B, Klöcking R & Hänninen KI (1994) Phenolkörperpolymerisate als Modellsubstanzen für natürliche Huminsäuren: Darstellung und vorläufige Charakterisierung. TELMA 24:131-142.
10. Klöcking R, Schacke M & Wutzler P (1995) Primärscreening anti-herpetischcr Verbindungen mit EZ4U. Chemotherapie Journal 5:141-147.
11. Klöcking R & Sprößig M (1972) Antiviral properties of humic acids. Experientia 28:607.
12. Klöcking R & Sprößig M (1975) Wirkung von Ammoniumhumar auf einige Virus-Zell-Systeme. Zeitschrift für Allgemeine Mikrobiologie 15:25-30.
13. Klöcking R, Sprößig M, Wutzler P, Thiel K-D & Helbig B (1983) Antiviral wirksame Huminsäuren und huminsäureähnliche Polymere. Zeitschrift für Physiotherapie 35:95-101.
14. Meerbach A, Neyts J, Balzarini J, Helbig B, De Clerq E & Wurzler P (2001) In vitro activity of polyhydroxycarboxylates against herpesviruses and HIV. Antiviral Chemistry & Chemotherapy 12:337-345.
15. Neyts J, Snoeck R, Wutzler P, Cushman M, Klöcking R, Helbig B, Wang P & De Clercq E (1992) Poly(hydroxy)carboxylates as selective inhibitors of cytomegalovirus and herpes simplex virus replication. Antiviral Chemistry & Chemotherapy 3:215-222.
16. Pauwels R, Balzafini J, Baba M, Snoeck R, Schols D, Hetdewijn P, Desmyter J & De Glercq E (1988) Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds. Journal of Virological Methods 20:309-321.
17. Schnitzer M & Khan SU (1972) Humic Substances in the Environment. New York: Marcel Dekker.
18. Schols D, Wutzler P, Klöcking R, Helbig B & De Clercq E (1991) Selective inhibitory activity of polyhydroxycarbolates derived from phenolic cumpounds against human immunodeficiency virus replication. Journal of Acquired Immune Deficiency Syndrome 4:677-685.
19. Schultz H (1962) Die viricide Wirkung der Huminsäuren im Torfmull auf das Virus der Maul- und Klauenseuche. Deutsche Tierärztliche Wochenschrift 69:613-616.
20. Thiel KD, Wutzler P, Helbig B, Klöcking P, Sprößig M & Schweizer H (1984) Antivirale Wirksamkeit von enzymatisch und nichtenzymatisch oxidierter Kaffee- und Hydrokaffeesäure gegenüber Herpesvirus hominis Typ 1 und Typ 2 in vitro. Pharmazie 39:781-782.
21. Thiel KD, Klöcking R & Helbig B (1976) In vitro studies of the antiviral activity of enzymatically oxidized o-diphenolic compounds against herpes simplex virus type 1 and type 2. Zentralblatt für Bakteriologie und Hygiene Abteilung Originale A 234:159-169.
22. Wang TSC & Wang MC (1993) Catalytic synthesis of humic substances by using aluminas as catalysts. Soil Science 136:226-230.