Identification of a novel inner-core oligosaccharide structure in Neisseria meningitidis lipopolysaccharide

European Journal of Biochemistry

Volumn 270, Issue 8, 2003, Pages 1759-1766

  Cox, Andrew D ^a   Wright, J Claire ^b   Gidney, Margaret A J ^a   Lacelle, Suzanne ^a   Plested, Joyce S ^b   Martin, Adele ^a   Moxon, E Richard ^b   Richards, James C ^a  

^a NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Lipopolysaccharide; Mass spectrometry; Neisseria meningitidis; NMR; Oligosaccharide

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; DIHEPTOSYL N ACETYLGLUCOSAMINE; EPITOPE; GLUCOSAMINE; GLUCOSE; HEPTOSE; LIPOPOLYSACCHARIDE; MONOCLONAL ANTIBODY; MONOSACCHARIDE; OLIGOSACCHARIDE; PHOSPHOETHANOLAMINE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL STRAIN; CARBON NUCLEAR MAGNETIC RESONANCE; DEACYLATION; HOST; MASS SPECTROMETRY; NEISSERIA MENINGITIDIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN INTERACTION; PROTEIN MODIFICATION; PROTEIN STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE; WASTE;

CARBOHYDRATE CONFORMATION; CARBOHYDRATE SEQUENCE; LIPOPOLYSACCHARIDES; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR SEQUENCE DATA; NEISSERIA MENINGITIDIS; OLIGOSACCHARIDES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

BACTERIA (MICROORGANISMS); NEGIBACTERIA; NEISSERIA; NEISSERIA MENINGITIDIS;

EID: 0038409052     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1033.2003.03535.x     Document Type: Article

References (24)

1. Kahler, C.M. & Stephens, D.S. (1998) Genetic basis for biosynthesis, structure, and function of meningococcal lipooligosaccharide (endotoxin). Crit. Rev. Microbiol. 24, 281-334.
2. Scholten, R.J., Kuipers, B., Valkenburg, H.A., Dankert, J., Zollinger, W.D. & Poolman, J.T. (1994) Lipo-oligosaccharide immunotyping of Neiaseria meningitidis by a whole-cell ELISA with monoclonal antibodies, J. Med. Microbiol. 41, 236-243.
3. Di Fabio, J.L., Michon, F., Brisson, J. & Jennings, H.J. (1990) Structure of L1 and L6 core oligosaccharide epitopes of Neisseria meningitidis. Can. J. Chem. 68, 1029-1034.
4. Wakarchuk, W.W., Gilbert, M., Martin, A., Wu, Y., Brisson, J.R., Thibault, P. & Richards, J.C. (1998) Structure of an alpha-2,6-sialylated lipooligosaccharide from Neisseria meningitidis immunotype L1. Eur. J. Biochem. 254, 626-633.
5. Gamian, A., Beurret, M., Michon, F., Brisson, J.R. & Jennings, H.J. (1992) Structure of the L2 lipopolysaccharide core oligosaccharides of Neiaseria meningitidis. J. Biol. Chem. 267, 922-925.
6. Pavliak, V., Brisson, J.R., Michon, F., Uhrin, D. & Jennings, H.J. (1993) Structure of the sialylated L3 lipopolysaccharide of Neixseria meningitidis. J. Biol. Chem. 268, 14146-14152.
7. Kogan, G., Uhrin, D., Brisson, J.R. & Jennings, H.J. (1997) Structural basis of the Neisseria meningitidis immunotypes including the L4 and L7 immunotypes. Carbohydr. Res. 298, 191-199.
8. Michon, F., Beurret, M., Gamian, A., Brisson, J.R. & Jennings, H.J. (1990) Structure of the L5 lipopolysaccharide core oligosaccharides of Neisseria meningitidis. J. Biol. Chem. 265, 7243-7247.
9. Jennings, H.J., Johnson, K.G. & Kenne, L. (1983) The structure of an R.-type oligosaccharide core obtained from some lipopolysaccharides of Neixseria meningitidis. Carbohydr. Res. 121, 233-241.
10. Cox, A.D., Li, J., Brisson, J.-R., Moxon, E.R. & Richards, J.C. (2002) Structural analysis of the lipopolysaccharide from Neisseria meningitidis strain BZ157 galE: localisation of two phosphoethanolamine residues in the inner core oligosaccharide. Carbohydr. Res. 337, 1435-1444.
11. Jennings, M.P., van der Ley, P., Wilks, K.E., Maskell, D.J., Poolman, J.T. & Moxon, E.R. (1993) Cloning and molecular analysis of the galE gene of Neisseria meningitidis and its role in lipopolysaccharide biosynthesis. Mol. Microbiol. 10, 361-369.
12. Plested, J.S., Makepeace, K., Jennings, M.P., Gidney, M.A., Lacelle, S., Brisson, J., Cox, A.D., Martin, A., Bird, A.G., Tang, C.M., Mackinnon, F.G., Richards, J.C. & Moxon, E.R. (1999) Conservation and accessibility of an inner core lipopolysaccharide epitope of Neisseria meningitidis. Infect. Immun. 67, 5417-5426.
13. Seiler, A., Reinhardt, R., Sakari, J., Caugant, D.A. & Achtman, M. (1996) Allelic polymorphisms and site-specific recombination in the opc locus of Neisseria meningitidis. Mol. Microbiol. 19, 841-856.
14. Jolley, K.A., Kalmusova, J., Feil, E.J., Gupta, S., Musilek, M., Kriz, P. & Maiden, M.C.J. (2000) Carried meningococci in the Czech Republic: a diverse recombining population. J. Clin. Microbiol. 38, 4492-498.
15. Harrison, O.B., Robertson, B.D., Faust, S.N., Jepson, M.A., Goldin R.D., Levin, M. & Heyderman, R.S. (2002) Analysis of pathogen-host cell interactions in purpura fulminans: expression of capsule, type IV pili, and porA by Neisseria meningitidis in vivo. Infect. Immun. 70, 5193-5201.
16. Lysenko, E., Richards, J.C., Cox, A.D., Stewart, A., Martin, A., Kapoor, M. & Weiser, J.N. (2000) The position of phosphorylcholine on the lipopolysaccharide of Haemophilus influenzae affects binding and sensitivity to C-reactive protein-mediated killing. Mol. Microbiol. 35, 234-245.
17. Mackinnon, F.G., Cox, A.D., Plested, J.S., Tang, C.T., Makepeace, K., Coull, P.A., Wright, J.C., Chalmers, R., Hood, D.W., Richards, J.C. & Moxon, E.R. (2002) Identification of a gene (lpt-3) required for the addition of phosphoethanolamine to the lipopolysaccharide inner core of Neisseria meningitidis and its role in mediating susceptibility to bactericidal killing and opsonophagocytosis. Mol. Microbiol. 43, 931-943.
18. Cox, A.D., Li, J. & Richards, J.C. (2002) Identification and localisation of glycine in the inner core lipopolysaccharide of Neisseria meningitidis. Eur. J. Biochem. 269, 4169-4175.
19. Risberg, A., Masoud, H., Martin, A., Richards, J.C., Moxon, E.R. & Schweda, E.K.H. (1999) Structural analysis of the lipopolysaccharide oligosaccharide epitopes expressed by a capsule-deficient strain of Haemophitus influenzae Rd. Eur. J. Biochem. 261, 171-180.
20. Cox, A.D., Brisson, J.-R., Thibault, P., Perry, M.B. (1997) Structural analysis of the lipopolysaccharide from Vibrio cholerae serotype O22. Carbohydr. Res. 303, 191-208.
21. Brisson, J.-R., Crawford, E., Uhrin, D., Khieu, N.H., Perry, M.B., Severn, W.B. & Richards, J.C. (2002) The core oligosaccharide component from Mannheimia (Pasteurella) haemolytica serotype A1 lipopolysaccharide contains 1-glycero-D-manno- and D-glycero-D-manno-heptoses. Analysis of the structure and conformation by high-resolution NMR spectroscopy. Can. J. Chem. 80, 949-963.
22. Kondo, S., Zähringer, U., Seydel, U., Sinnwell, V., Hisatsune, K. & Rietschel, E.T. (1991) Chemical structure of the carbohydrate backbone of Vibrio haemolyticus serotype O12 lipopolysaccharide. Eur. J. Biochem. 200, 689-698.
23. Aspinall, G.O., Monteiro, M.A., Pang, H., Kurjanczyk, L.A. & Penner, J.L. (1995) Lipo-oligosaccharide of Campylobacter lari strain PC 637. Structure of the liberated oligosaccharide and an associated extracellular polysaccharide. Carbohydr. Res. 279, 227-244.
24. Aspinall, G.O., Monteiro, M.A. & Pang, H. (1995) Lipo-oligosaccharide of Campylobacter lari type strain ATCC 35221. Structure of the liberated oligosaccharide and an associated extracellular polysaccharide. Carbohydr. Res. 279, 245-264.