Triple therapy for 7 days vs. triple therapy for 7 days plus omeprazole for 21 days in treatment of active duodenal ulcer with Helicobacter pylori infection. A double blind placebo controlled trial

Digestive and Liver Disease

Volumn 35, Issue 1, 2003, Pages 20-23

  Marzio, L ^a   Cellini, L ^a   Angelucci, D ^a  

^a UNIVERSITY OF CHIETI   (Italy)

Author keywords

Active duodenal ulcer; Helicobacter pylori; Proton pump inhibitors; Triple therapy

Indexed keywords

ANTIBIOTIC AGENT; CLARITHROMYCIN; ESOMEPRAZOLE; LANSOPRAZOLE; OMEPRAZOLE; STOMACH SECRETION INHIBITOR; TINIDAZOLE; UREASE;

ADULT; AGED; ARTICLE; BITTER TASTE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DOUBLE BLIND PROCEDURE; DUODENOSCOPY; DUODENUM ULCER; ERADICATION THERAPY; FEMALE; HELICOBACTER INFECTION; HISTOLOGY; HUMAN; MAJOR CLINICAL STUDY; MALE; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; RECURRENT PEPTIC ULCER; TREATMENT OUTCOME; ULCER HEALING;

EID: 0038407465     PISSN: 15908658     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1590-8658(02)00006-3     Document Type: Article

References (16)

1. The European Helicobacter pylori Study Group. Current European concepts in management of Helicobacter pylori infection. The Maastricht Consensus report. Gut 1997;41:8-13.
2. Consensus Conference. Medical treatment of peptic ulcer disease. Practice guidelines. Practice Parameters. Committee of the American College of Gastroenterology. J Am Med Assoc 1996;275:622-9.
3. Tucci A, Corinaldesi R, Stanghellini V, Tosetti C, Di Febo G, Paparo GF, et al. Helicobacter pylori infection and gastric function in patients with chronic idiopathic dyspepsia. Gastroenterology 1992;103:768-74.
4. Di Mario F, Battaglia F, Dal Bo N, Leandro G, Benedetti E, Bottona E, et al. Cure of Helicobacter pylori-positive active duodenal ulcer patients: a double blind, multicentre, 12-month study comparing a two-week dual vs. one-week triple therapy. Digest Liver Dis 2000;32:108-15.
5. Zanten SJ, Bradette M, Farley A, Leddin D, Lind T, Unge P, et al. The DU-MACH study: eradication of Helicobacter pylori and ulcer healing in patients with acute duodenal ulcer using omeprazole based triple therapy. Aliment Pharmacol Ther 1999;13:289-95.
6. Vcev A, Stimac D, Vceva A, Takac B, Pezerovic D, Ivandic A. High dose omeprazole plus amoxicillin and azithromycin in eradication of Helicobacter pylori in duodenal ulcers. Helicobacter 1999;4:54-7.
7. Magalhaes AF, Macedo C, Hauck JR, Carvalhaes A, De Nucci G, Magna LA, et al. Acid suppression with ranitidine plus oral triple therapy improves ulcer healing but not Helicobacter pylori eradication. Hepatogastroenterology 1998;45:2161-4.
8. Laine L, Suchower L, Frantz J, Connors A, Neil G. Twice daily, 10-day triple therapy with omeprazole, amoxicillin, and clarithromycin for Helicobacter pylori eradication in duodenal ulcer disease: results of three multicenter, double blind, United States trial. Am J Gastroenterol 1998;93:2106-12.
9. Toracchio S, Cellini L, Di Campli E, Cappello G, Malatesta MG, Ferri A, et al. Role of antimicrobial susceptibility testing on efficacy of triple therapy in Helicobacter pylori eradication. Aliment Pharmacol Ther 2000;14:1639-43.
10. Harris AW, Misiewicz JJ, Bardhan KD, Levi S, O'Morain C, Cooper BT, et al. Incidence of duodenal ulcer healing after 1 week of proton pump inhibitor triple therapy for eradication of Helicobacter pylori. The Lansoprazole Helicobacter Study Group. Aliment Pharmacol Ther 1998;12:741-5.
11. Spinzi GC, Boni F, Bortoli A, Colombo E, Ballardini G, Venturelli R, et al. Seven-day triple therapy with ranitidine bismuth citrate or omeprazole and two antibiotics for eradication of Heliocbacter pylori in duodenal ulcer: a multicentre, randomized, single-blind study. Aliment Pharmacol Ther 2000;14:325-30.
12. Tulassay Z, Kryszewski A, Dite P, Kleczkowski D, Rudzinski J, Bartuzi Z, et al. One week treatment with esomeprazole-based triple therapy eradicates Helicobacter pylori and heals patients with duodenal ulcer disease. Eur J Gastroenterol Hepatol 2001;13:1457-65.
13. Wong BC, Wang WH, Wong WM, Lau GK, Fung FM, Kung NN, et al. Three-day lansoprazole quadruple therapy for Helicobacter pylori positive duodenal ulcers: a randomized controlled study. Aliment Pharmacol Ther 2001;15:843-9.
14. Graham DY, McCullough A, Sklar M, Sontag SJ, Roufail WM, Stone RC, et al. Omeprazole versus placebo in duodenal ulcer healing. The United States experience. Dig Dis Sci 1990;35:66-72.
15. Logan RP, Gummett PA, Misiewicz JJ, Karim QN, Walker MM, Baron JH. One week's anti-Helicobacter pylori treatment for duodenal ulcer. Gut 1994;35:15-8.
16. Sung JJ, Chung SC, Ling TK, Yung MY, Leung VK, Ng EK, et al. Antibacterial treatment of gastric ulcers associated with Helicobacter pylori. N Engl J Med 1995;332:139-42.