Acetylcholinesterease activity in rat brain regions following acephate exposure for 4, 14 and 60 days

Toxicological and Environmental Chemistry

Volumn 84, Issue 1-4, 2001, Pages 69-77

  Kumar, S ^a,b  

^a Dr ALM Postgraduate Institute of Basic Medical Sciences   (India)

^b LOYOLA UNIVERSITY CHICAGO   (United States)

Author keywords

Acephate; Acetylcholinesterase; Brain regions; Rat

Indexed keywords

BRAIN; ENZYMES; PESTICIDES; PHOSPHORUS COMPOUNDS; TISSUE; TOXICITY;

ENZYME ACTIVITY;

ORGANIC COMPOUNDS;

POLLUTION EXPOSURE;

EID: 0038384626     PISSN: 02772248     EISSN: None     Source Type: Journal    
DOI: 10.1080/02772240309814     Document Type: Article

References (36)

1. J.K. Marquis (1986). Contemporary Issues in Pesticide Toxicology and Pharmacology, Concepts in Toxicology, Vol. 2, pp. 40-59. Karger, USA.
2. D. Milatovic and W.D. Dettbarn (1996). Modification of acetylcholinesterase during adaptation to chronic, subacute paraoxon application in rat. Toxicol. Appl. Pharmacol., 136, 20-28.
3. WHO (1986). Task group on Environmental Health Criteria. Organophosphorous Insecticides: A General Introduction. World Health Organization, Geneva.
4. N.B. Vyas, W.J. Kuenzel, E.F. Hill, G.A. Romo and M.V.S. Komaragiri (1996). Regional cholinesterase activity in white throated sparrow brain is differentially affected by acephate (Orthene). Comp. Biochem. Physiol., 113C(3), 381-386.
5. P. Fosbraey, J.R. Wetherell and M.C. French (1990). Neurotransmittter changes in guinea-pig brain regions following soman intoxication. J. Neurochem., 54(1), 72-79.
6. Y. Finkelstein, U. Taitelman and A. Biegon (1988). CNS involvement in acute organophosphate poisoning: specific pattern of toxicity, clinical correlates and antidotal treatment. Ital. J. Neurol. Sci., 9(5), 437-446.
7. J.D. Stone, A.V. Terry, J.R. Pauly, M.A. Prendergast and J.J. Buccafusco (2000) Protractive effects of chronic treatment with an acutely sub-toxic regimen of diisopropylflurophosphate on the expression of cholinergic receptor densities in rats. Brain Res., 882(1-2), 9-18.
8. Z. Rakonczay and H. Papp (2001). Effects of chronic metrifonate treatment on cholinergic enzymes and the blood-brain barrier. Neurochem. Int., 39(1), 19-24.
9. S. Kumar (2001). Acute toxicity of aluminium chloride, acephate, and their coexposure in male Wistar rat. Int. J. Toxicol., 20(4), 219-223.
10. 3H] DOPA in various regions of rat brain. J. Neurochem., 13, 655-699.
11. G.L. Ellman, K.D. Courtney, V. Andres and R.M. Featherstone (1961) A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem. Pharmacol., 7, 88-95.
12. C. Rosenfeld, A. Kousba, L.G. Sultatos (2001). Interactions of rat brain acetylcholinesterase with the detergent Triton X-100 and the organophosphate paraoxon. Toxicol Sci., 63(2), 208-213.
13. O.H. Lowry, N.J. Rosebrough, A.L. Farr and R.J. Randall (1951). Protein measurement with the folin phenol reagent. J. Biol. Chem., 193, 265-275.
14. J.H. Zar (1984). Biostatistics, 2nd Edn. Prentice Hall International, New Jersey, USA.
15. L.J. Thal, P.A. Fuld, D.M. Masur and N.S. Sharpless (1983). Oral physostigmine and lecithin improve memory in Alzheimer's disease. Ann. Neurol., 13, 491-496.
16. P. Ivanov, B. Georgiev, K. Kirov and L. Venkov (1993). Correlation between concentration of cholinesterases and the resistance of animals to organophosphorous compounds. Drug Chem. Toxicol., 16(1), 81-99.
17. M.A. Hussain, R.B. Mohamed and P.C. Olofts (1984). Toxicity and metabolism of acephate in adult and larval insects. J. Environ. Sci. Health, 19(3), 355-377.
18. M.A. Hussain (1987). Anticholinesterase properties of methamidophos and acephate in insects and mammals. Bull. Environ. Contain. Toxicol., 38, 131-138.
19. A.K. Singh (1984). Improved analysis of acephate and methamidophos in biological samples by selective ion monitoring gas chromatography-mass spectrometry. J. Chromatogr., 301, 465-469.
20. M. Maroni, G. Catenacci, D. Galli, D. Cavallo and G. Ravazzani (1990). Biological monitoring of human exposure to acephate. Arch. Environ. Contam. Toxicol., 19, 782-788.
21. H. Lee (1972). Metabolism of ORTHENE in rats; Unpublished report quoted in FAO, 1977.
22. FAO (1977). Evaluation of pesticide residues in food. The monographs; ACEPHATE. FAO plant production and protection series, Rome 1976.
23. FAO (1985). Pesticide residues in food. The monographs - ACEPHATE FAO plant production and protection paper 67; Food and Agriculture Organisation of the United Nations, Rome, 1984.
24. D. Spassova, T. White and A.K. Singh (2000). Acute effects of acephate and methamidophos on acetylcholinesterase activity, endocrine system and amino acid concentrations in rats. Comp. Biochem. Physiol. C Toxicol. Pharmacol., 126(1), 79-89.
25. A.K. Singh (1990). Molecular properties and inhibition kinetics of acetylcholinesterase obtained from rat brain and cockroach ganglion. Toxicol. Ind. Health., 6(6), 551-570.
26. A.K. Singh (1985). Kinetic analysis of inhibition of brain and red blood cell acetylcholinesterase and plasma cholinesterase by acephate or methamidophos. Toxicol. Appl. Pharmacol., 81(2), 302-309.
27. G. Bignami and H. Michalek (1978). Cholinergic mechanisms and aversively motivated behavior. In: A. Bignami (Ed.), Psychopharmacology of Aversively Motivated Behavior, pp. 173-255. Plenum Publishing, New York.
28. H. Michalek, A. Meneguz, G.M. Bisso, G. Carro-cicumpi, G.L. Gatti and G. Bignami (1979). Neurochemical changes associated with the behavioural toxicity of organophosphate compounds. Adv. Pharmacol. Ther., 9, 187-201.
29. L.G. Costa, B.W. Schwab and S.D. Murphy (1982). Tolerance to anticholinesterase compounds in mammals. Toxicology, 25, 79-97.
30. J. Brodeur and K.P. Du Bois (1964). Studies on the mechanism of acquired tolerance by rats to O,O-diethyl-S-2-(ethylthio) ethyl phosphorodithioate (Di-Syston). Arch. Int. Pharmacodyn., 149, 560-570.
31. R.W. Russell, D.H. Overstreet, C.W. Cotman, V.G. Carson, L. Churchill, F.W. Dalglish and B.J. Vasquez (1975). Experimental tests of hypotheses about neurochemical mechanisms underlying behavioural tolerance to the anticholinesterase, disopropylfluorophosphate. J. Pharmacol. Exp. Ther., 192, 73-85.
32. R.W. Russell, V.G. Carson, R.A. Booth and D.J. Jenden (1981). Mechanisms of tolerance to the anticholinesterase DFP: acetylcholine levels and dynamics in the rat brain. Neuropharmacology, 20, 1197-1201.
33. J. Liu, K. Olivier and C.N. Pope (1999). Comparative neurochemical effects of repeated methyl parathion or chlorpyrifos exposures in neonatal and adult rats. Toxicol. Appl. Pharmacol., 158(2),186-196.
34. A.K. Singh and L.R. Drewes (1987). Neurotoxic effects of low level chronic acephate exposure in rats. Environ. Res., 43, 342-349.
35. J.G. Clement (1994). Chromodacryorrhea in rats: absence following soman poisoning. Toxicol. Appl. Pharmacol., 124, 52-58.
36. K.V. Swamy, R. Ravikumar and P.M. Mohan (1992). Changes in cholinesterase system in different brain areas during the development of behavioral tolerance to monocrotophos toxicity in male albino rats. Biochem. Int., 27(4), 661-669.