Cellular mechanisms of osteolysis

Journal of Bone and Joint Surgery

Volumn 85, Issue SUPPL. 2, 2003, Pages 4-6

  Clohisy, Denis ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIGAND; OSTEOPROTEGERIN; CARRIER PROTEIN; CELL RECEPTOR; GLYCOPROTEIN; MEMBRANE PROTEIN; OSTEOCLAST DIFFERENTIATION FACTOR; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B; TNFRSF11A PROTEIN, HUMAN; TNFRSF11B PROTEIN, HUMAN; TNFSF11 PROTEIN, HUMAN; TUMOR NECROSIS FACTOR RECEPTOR;

ARTICLE; BONE TUMOR; CELL ACTIVATION; CELL ACTIVITY; CELL FUNCTION; HUMAN; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOCLAST; OSTEOLYSIS; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STEM CELL; STROMA CELL; ANIMAL; JOINT PROSTHESIS; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; BONE NEOPLASMS; CARRIER PROTEINS; GLYCOPROTEINS; HUMANS; JOINT PROSTHESIS; MEMBRANE GLYCOPROTEINS; OSTEOBLASTS; OSTEOCLASTS; OSTEOLYSIS; OSTEOPROTEGERIN; RANK LIGAND; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, TUMOR NECROSIS FACTOR; STROMAL CELLS;

EID: 0038373869     PISSN: 00219355     EISSN: None     Source Type: Journal    
DOI: 10.2106/00004623-200300001-00002     Document Type: Article

References (4)

1. Hofbauer LC, Khosla S, Dunstan CR, Lacey DL, Boyle WJ, Riggs BL. The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption. J Bone Miner Res. 2000;15:2-12.
2. Clohisy DR, Ramnaraine ML, Scully S, Ql M, Van G, Tan HL, Lacey DL. Osteoprotegerin inhibits tumor-induced osteoclastogenesis and bone tumor growth in osteopetrotic mice. J Orthop Res. 2000;18:967-76.
3. Honore P, Luger NM, Sabino MA, Schwel MJ, Rogers SD, Mach DB, O'Keefe PF, Ramnaraine ML, Clohisy DR, Mantyh PW. Osteoprotegerin blocks bone cancer-induced skeletal destruction, skeletal pain and pain-related neurochemical reorganization of the spinal cord. Nat Med. 2000;6:521-28.
4. Childs LM, Paschalis EP, Xing L, Dougall WC, Anderson D, Boskey AL, Puzas JE, Rosler RN, O'Keefe RJ, Boyce BF, Schwarz EM. In vivo RANK signaling blockade using the receptor activator of NF-kappaB:Fc effectively prevents and ameliorates wear debris-induced osteolysis via osteoclast depletion without inhibiting osteogenesis. J Bone Miner Res. 2002;17:192-9.