On-chip THz detection of biomaterials: A numerical study

Journal of Biological Physics

Volumn 29, Issue 2-3, 2003, Pages 187-194

  Baras, T ^a   Kleine Ostmann, T ^a   Koch, M ^a  

^a TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

Author keywords

Lab on chip; Marker free DNA testing; Numerical simulations; On chip DNA analysis; Parallel coupled filter; Ring resonator; THz on chip detection; THz spectroscopy

Indexed keywords

BIOMATERIAL; DNA;

COMPUTER PROGRAM; COMPUTER SIMULATION; CONFERENCE PAPER; DNA DENATURATION; DNA DETERMINATION; DNA PROBE; FILM; FILTER; GEOMETRY; MATHEMATICAL ANALYSIS; PRIORITY JOURNAL; SPECTROSCOPY; TECHNOLOGY; TERAHERTZ SPECTROSCOPY; THICKNESS;

EID: 0038373289     PISSN: 00920606     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1024444809852     Document Type: Conference Paper

References (8)

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2. Zhu, Z., Chao, J., Yu, H. and Waggoner, A.S.: Directly labeled DNA Probes using Fluorescent Nucleotides with Different Length Linkers, Nucl. Acids Res. 22 (1994), 3418-3422.
3. Nagel, M., Haring Bolivar, P., Brucherseifer, M., Kurz, H., Bosserhoff, A. and Büttner, R.: Integrated THz Technology for Label-Free Genetic Diagnostics, Appl. Phys. Lett. 80 (2002), 154-156.
4. Valdmanis, J.A. and Mourou, G.A.: Subpicosecond Electrooptic Sampling: Principles and Applications, IEEE J. Quant. Electr. 22 (1986), 69-78.
5. Markelz, A.G., Roitberg, A. and Heilweil, E.J.: Pulsed Terahertz Spectroscopy of DNA, Bovine Serum Albumin and Collagen between 0.1 and 2.0 THz, Chem. Phys. Lett. 320 (2000), 42-48.
6. Haring Bolivar, P.: private communication.
7. The simulation program is scalable and there is no obvious reason why it should not work at THz frequencies. We will cross-validate this, however, in the next future by using alternative simulation software from other providers.
8. Brucherseifer, M., Nagel, M., Haring Bolivar, P., Kurz, H., Bosserhoff, A. and Büttner, R.: Label-Free Probing of the Binding State of DNA by Time-Domain Terahertz Sensing, Appl. Phys. Lett. 77 (2000), 4049-4051.