1H MRS of a boron neutron capture therapy 10B-carrier, L-p-boronphenylalanine-fructose complex, BPA-F: Phantom studies at 1.5 and 3.0 T

Physics in Medicine and Biology

Volumn 48, Issue 8, 2003, Pages 1027-1039

  Heikkinen, Sami ^a   Kangasmaki A ^a   Timonen, M ^a   Kankaanranta, L ^a   Hakkinen A M ^a   Lundbom, N ^a,b   Vahatalo J ^c   Savolainen, S ^a  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^b AALTO UNIVERSITY   (Finland)

^c UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMEDICAL ENGINEERING; BORON; FRUCTOSE; NEUTRONS; PROTONS; RELAXATION PROCESSES;

NEUTRON CAPTURE THERAPY;

MAGNETIC RESONANCE SPECTROSCOPY;

4 BORONOPHENYLALANINE; BORON 10; FRUCTOSE; 4 DIHYDROXYBORYLPHENYLALANINE; 4-DIHYDROXYBORYLPHENYLALANINE; BORON DERIVATIVE; DRUG DERIVATIVE; PHENYLALANINE; PROTON;

ACCURACY; AQUEOUS SOLUTION; ARTICLE; CHEMICAL STRUCTURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; IMAGING SYSTEM; IN VIVO STUDY; NEUTRON CAPTURE THERAPY; PHANTOM; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SIMULATION; COMPARATIVE STUDY; COMPUTER ASSISTED RADIOTHERAPY; COMPUTER SIMULATION; EVALUATION; FEASIBILITY STUDY; IMAGE QUALITY; INSTRUMENTATION; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RADIATION DOSE; RADIATION RESPONSE; RADIOMETRY; THEORETICAL MODEL; VALIDATION STUDY;

BORON COMPOUNDS; BORON NEUTRON CAPTURE THERAPY; COMPUTER SIMULATION; DOSE-RESPONSE RELATIONSHIP, RADIATION; FEASIBILITY STUDIES; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, THEORETICAL; PHANTOMS, IMAGING; PHENYLALANINE; PROTONS; RADIOMETRY; RADIOTHERAPY DOSAGE; RADIOTHERAPY PLANNING, COMPUTER-ASSISTED;

EID: 0038367601     PISSN: 00319155     EISSN: None     Source Type: Journal    
DOI: 10.1088/0031-9155/48/8/305     Document Type: Article

References (39)

1. Bendel P, Frantz A, Zilberstein J, Kabalka G W and Salomon Y 1998 Boron-11 NMR of borocaptate: relaxation and in vivo detection in melanoma-bearing mice Magn. Reson. Med. 39 439-47
2. 10B MRI Magn. Reson. Med. 46 13-7
3. 10B NMR Med. Phys. 28 178-83
4. 10B double resonance Magn. Reson. Med. 32 170-4
5. Bothner-By A A and Castellano S 1967 QCPE 111. LAOCN3: Program for the analysis of high-resolution spectra QCPE 11 111
6. Bottomley P A 1987 Spatial localization in NMR spectroscopy in vivo Ann. New York Acad. Sci. 508 333-48
7. Campanella R, Capuani S, Fasano F and Maraviglia B 2002 Double resonance NMR imaging of BSH Research and Development in Neutron Capture Therapy (Essen, Germany Sep. 8-13) ed W Sauerwein, R Moss and A Wittig (Bologna, Italy: Moduzzi Editore) pp 963-5
8. Castellano S and Bothner-By A A 1964 Analysis of NMR spectra by least squares J. Chem. Phys. 41 3863-9
9. 1H-MRS using water as an internal standard Magn. Reson. Imaging 11 107-18
10. Coderre J A et al 1998 Biodistribution of boronophenylalanine in patients with glioblastoma multiforme: boron concentration correlates with tumor cellularity Radiat. Res. 149 163-70
11. Elowitz E H et al 1998 Biodistribution of p-boronophenylalanine in patients with glioblastoma multiforme for use in boron neutron capture therapy Neurosurgery 42 463-9
12. 2 measurements using a CPMG-OSIRIS Method NMR Biomed. 7 343-8
13. Gordon R E and Ordidge R J 1984 Volume selection for high-resolution NMR studies Book of Abstracts: Third Annual Meeting of the Society of Magnetic Resonance in Medicine (Berkeley, CA: SMRM) p 272
14. 1H proton NMR chemical shift selective (CHESS) imaging Phys. Med. Biol. 30 341-4
15. Hennig J, Thiel T and Speck O 1997 Improved sensitivity to overlapping multiplet signals in in vivo proton spectroscopy using a multiecho volume selective (CPRESS) experiment Magn. Reson. Med. 37 816-20
16. Joensuu H et al 2003 Boron neutron capture therapy of brain tumors: clinical trials at the Finnish facility using boronophenylalanine J. Neurooncol. at press
17. 1H NMR spectroscopy J. Magn. Reson. 152 203-13
18. Kabalka G W, Tang C and Bendel P 1997 The role of boron MRI in boron neutron capture therapy J. Neurooncol. 33 153-61
19. Keevil S F et al 1998 Absolute metabolite quantification by in vivo NMR spectroscopy: II. A multicentre trial of protocols for in vivo localised proton studies of human brain Magn. Reson. Imaging. 16 1093-106
20. Kortesniemi M 2002 Solutions for clinical implementation of boron neutron capture therapy in Finland PhD Thesis University of Helsinki (webpage http://ethesis.helsinki.fi/julkaisut/mat/fysik/vk/kortesniemi/)
21. 1H MR spectroscopy for clinical use Prog. Nucl. Magn. Reson. Spectr. 31 155-95
22. Laakso J et al 2001 Atomic emission method for total boron in blood during neutron-capture therapy Clin. Chem. 47 1796-7803
23. Laatikainen R 1992 QCPE 613. MLDC8: automated analysis of NMR spectra QCPE Bull. 12 23
24. Laatikainen R, Niemitz M, Weber U, Sundelin J, Hassinen T and Vepsäläinen J 1996 General strategies for total-line-shape type spectral analysis of' NMR spectra using integral transform iterator J. Magn. Reson. A 120 1-10
25. 1H MRS Magn. Reson. Med. 38 415-9
26. Marshall I and Wild J 1998 A systematic study of the lactate lineshape in PRESS-localized proton spectroscopy Magn. Reson. Med. 40 72-8
27. Michaelis T, Merboldt K D, Bruhn H, Hänicke W and Frahm J 1993 Absolute concentrations of metabolites in the adult human brain in vivo: quantification of localized proton MR spectra Radiology 187 219-27
28. Michaeli S et al 2002 Proton T, relaxation study of water, N-acetylaspartate, and creatine in human brain using Hahn and Carr-Purcell spin echoes at 4T and 7T Magn. Reson. Med. 47 629-33
29. Nicholas P, Fushman D, Ruchinsky V and Cowburn D 2000 The virtual NMR spectrometer: a computer program for efficient simulation of NMR experiments involving pulsed field gradients J. Magn. Reson. 145 262-75
30. Nichols T L, Kabalka G W, Miller L F, Khan M K and Smith G T 2002 Improved treatment planning for boron neutron capture therapy for glioblastoma multiforme using fluorine-18 labeled boronophenylalanine and positron emission tomography Med. Phys. 29 2351-8
31. 10B concentration after BPA-fructose complex infusion in patients during epithermal neutron irradiation in BNCT Int. J. Radiat. Oncol. Biol. Phys. 48 1145-54
32. 10B in blood after BPA-fructose complex infusion Phys. Med. Biol. 47 737-45
33. Schick F et al 1996 Sequence parameters of double spin-echo sequences affect quantification of citrate Magn. Reson. Imaging 14 663-72
34. 13C NMR evidence for the β-D-fructofuranose 2,3,6-(p-phenylalanyl-orthoborate) structure J. Pharm. Sci. 89 215-22
35. Thompson R B and Allen P S 1999 Sources of variability in the response of coupled spins to the PRESS sequence and their potential impact on metabolite quantification Magn. Reson. Med. 41 1162-9
36. Thompson R B and Allen P S 2001 Response of metabolites with coupled spins to the STEAM sequence Magn. Reson. Med. 45 955-65
37. 1H MRS localization sequences J. Magn. Reson. B 107 25-33
38. Wilman A H and Allen P S 1996 Observing N-acetyl aspartate via both its N-acetyl and its strongly coupled aspartate groups in in vivo proton magnetic resonance spectroscopy J. Magn. Reson. B 113 203-13
39. Zuo C S, Prasad P V, Busse P, Tang L and Zamenhof R G 1999 Proton nuclear magnetic resonance measurement of p-boronophenylalanine (BPA): a therapeutic agent for boron neutron capture Med. Phys. 26 1230-6