Olprinone for the treatment, but not prevention, of fatigue-induced changes in guinea-pig diaphragmatic contractility

Anesthesia and Analgesia

Volumn 96, Issue 6, 2003, Pages 1679-1682

  Uemura, Aki ^a   Fujii, Yoshitaka ^a   Toyooka, Hidenori ^a   Suzuki, Setsuko ^b   Sawada, Kohei ^b   Adachi, Hideyuki ^b  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b EISAI CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

LOPRINONE; PHOSPHODIESTERASE INHIBITOR;

ANESTHESIA MECHANISM; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIAPHRAGM MOVEMENT; DRUG EFFECT; DRUG EFFICACY; ENZYME INHIBITION; FATIGUE; GUINEA PIG; IN VITRO STUDY; IN VIVO STUDY; MALE; MUSCLE CONTRACTILITY; MUSCLE TWITCH; NONHUMAN; PRIORITY JOURNAL; RANDOMIZATION;

EID: 0038362486     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/01.ane.0000064200.48151.69     Document Type: Article

References (13)

1. Cohen CA, Zagelbaum G, Gross D, et al. Clinical manifestations of inspiratory muscle fatigue. Am J Med 1982;73:308-16.
2. Macklem PT, Roussos C. Respiratory muscle fatigue: a cause of respiratory failure? Clin Sci Mol Med 1977;53:419-22.
3. Aubier M, Murciano D, Viires N, et al. Diaphragmatic contractility enhanced by aminophylline: role of extracellular calcium. J Appl Physiol 1983;54:460-4.
4. Howell S, Roussos C. Isoproterenol and aminophylline improve contractility of fatigued diaphragm. Am Rev Respir Dis 1984;129:118-24.
5. Aubier M, Viires N, Murciano D, et al. Effects of digoxin on diaphragmatic strength generation. J Appl Physiol 1986;61:1767-74.
6. Aubier M, Murciano D, Menu Y, et al. Dopamine effects on diaphragmatic strength during acute respiratory failure in chronic obstructive pulmonary disease. Ann Intern Med 1989;110:17-23.
7. Fujii Y, Toyooka H, Ebata T, Amaha K. Contractility of fatigued diaphragm is improved by dobutamine. Can J Anaesth 1993;40:453-8.
8. Fujii Y, Toyooka H, Amaha K. Amrinone improves contractility of fatigued diaphragm in dogs. Can J Anaesth 1995;42:80-6.
9. Fujii Y, Takahashi S, Toyooka H. The effects of milrinone and its mechanism in the fatigued diaphragm in dogs. Anesth Analg 1998;87:1077-82.
10. Fujii Y, Takahashi S, Toyooka H. The effect of Olprinone compared with milrinone on diaphragmatic muscle function in dogs. Anesth Analg 1999;89:781-5.
11. Ogawa T, Ohhara H, Tsunoda H, et al. Cardiovascular effects of the new cardiotonic agent 1, 2-dihydro-6-methyl-2-oxo-5(imidazo[1, 2-alpyridin-6-yl)-3-pyridine carbonitrile hydrochloride monohydrate: studies on isolated guinea pig cardiac muscles. Arzneimittelforschung 1989;39:33-7.
12. Ohhara H, Ogawa T, Takeda M, et al. Cardiovascular effects of the new cardiotonic agent 1, 2-dihydro-6-methyl-2-oxo-5(imidazo[1, 2-alpyridin-6-yl)-3-pyridine carbonitrile hydrochloride monohydrate: studies in dogs. Arzneimittelforschung 1989;39:38-45.
13. Satoh H, Endoh M. Effects of a new cardiotonic agent 1, 2-dihydro6-methyl-2-oxo-5-(imidazo[1, 2-a]pyridin-6-yl)-3-pyridine carbonitrile hydrochloride monohydrate (E-1020) on contractile force and cyclic AMP metabolism in canine ventricular muscle. Jpn J Pharmacol 1990;52:215-24.