A simple two-step synthesis of indoles

Synthetic Communications

Volumn 33, Issue 13, 2003, Pages 2229-2233

  Walkington, Andrew ^a   Gray, Matthew ^a   Hossner, Frank ^a   Kitteringham, John ^a   Voyle, Martyn ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Hydrogenation; Indoles; Nucleophilic aromatic substitution

Indexed keywords

INDOLE DERIVATIVE;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CATALYSIS; PROTON NUCLEAR MAGNETIC RESONANCE; REDUCTION; SYNTHESIS;

EID: 0038353183     PISSN: 00397911     EISSN: None     Source Type: Journal    
DOI: 10.1081/SCC-120021501     Document Type: Article

References (6)

1. Andrews, I.P.; Faruk, E.A.; Gray, M.; Hossner, F.; Kitteringham, J.; Paknoham, S.J.; Voyle, M. PCT Int. Appl. 1999, WO 9943650.
2. Raucher, S.; Koolpe, G.A. Synthesis of substituted indoles via Meerwein arylation. J. Org. Chem. 1983, 48, 2066-2069.
3. Tischler, A.N.; Lanza, T.J. 6-Substituted indoles from o-halonitrobenzenes. Tetrahedron Letters 1986, 27, 1653-1656.
4. Kalir, A.; Pelah, Z. 6-Trifluoro-methylindole. Israel J. Chem. 1966, 4, 155-159.
5. Belley, M.; Scheigetz, J.; Dubé, P.; Dolman, S. Synthesis of Naminoindole ureas from ethyl 1-amino-6-(trifluoromethyl)-1H-indole-3-carboxylate. Synlett. 2001, 222-225.
6. Commercially available in bulk from a number of suppliers, e.g., Sigma-Aldrich.