Fabrication and evaluation of a new composite composed of tricalcium phosphate, gelatin and Chi-Li-Saan as a bone substitute

American Journal of Chinese Medicine

Volumn 30, Issue 4, 2002, Pages 471-482

  Yao, Chun Hsu ^a   Tsai, Chin Chuan ^b   Chen, Yueh Sheng ^c   Chang, Chen Jung ^a   Liu, Bai Shuan ^a   Lin, Chun Ching ^d   Tsuang, Yang Hwei ^e  

^a CHUNGTAI INST HLTH SCI TECHNOL   (Taiwan)

^b School of Post Baccalaureate Chinese Medicine   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^e CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Biomedical composite; Chi Li Saan; Gelatin; Tricalcium phosphate

Indexed keywords

CALCIUM PHOSPHATE CERAMIC; CHINESE DRUG; GELATIN; POLITEF; BETA-TRICALCIUM PHOSPHATE; BIOMATERIAL; CALCIUM PHOSPHATE; CHI LI SAAN; CHI-LI-SAAN; EXCIPIENT; HERBACEOUS AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOCOMPATIBILITY; BONE DEFECT; BONE GROWTH; BONE PROSTHESIS; BONE TRANSPLANTATION; CHINESE MEDICINE; COMPOSITE MATERIAL; CONTROLLED STUDY; FLUORESCENCE MICROSCOPY; NONHUMAN; RABBIT; SKULL; ANIMAL; BONE DEVELOPMENT; CHEMISTRY; DRUG EFFECT; FRACTURE; FRACTURE FIXATION; PATHOLOGY; RADIOGRAPHY;

ANIMALS; BIOCOMPATIBLE MATERIALS; BONE DEVELOPMENT; BONE SUBSTITUTES; CALCIUM PHOSPHATES; DRUGS, CHINESE HERBAL; EXCIPIENTS; FRACTURE FIXATION; FRACTURES, BONE; GELATIN; RABBITS; SKULL;

EID: 0038352256     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0192415X02000557     Document Type: Article

References (21)

1. Buck, B.E. and T.I. Malinin. Bone transplantation and human immunodeficiency syndrome (AIDS). Clin. Orthop. 240: 129-136, 1989.
2. Bunvell, R.G. History of bone grafting and bone substitutes with special reference to osteogenic induction. In: M.R. Urist, B.T. O'Connor and R.G. Burwell (eds.) Bone Grafts, Derivatives and Substitutes. B.H. Ltd., 1994, pp. 3-102.
3. Damien, J.C. and J.R. Parson. Bone graft and bone graft substitutes: a review of current technology and applications. J. Appl. Biomater. 2: 187-208, 1991.
4. Frame, J.W. A convenient animal model for testing bone substitute materials. J. Oral Surg. 38: 176-180, 1980.
5. Harvey, W.K., J.L. Pincock and V.J. Matukas. Evaluation of subcutaneously implanted hydroxyapatite-avitene mixture in rabbits. J. Oral Maxillofac. Surg. 43: 277-284, 1993.
6. Heppenstall, R. Bone grafting. In: R. Heppenstall (ed.) Fracture Treatment and Healing. W.B. Saunders, Philadelphia, 1980, pp. 97-112.
7. Holmes, R.E. and H.K. Hagler. Porous hydroxyapatite as a bone graft substitute in cranial reconstructive: a histometric study. Plast. Reconstr. Surg. 81: 662-671, 1988.
8. Holmes, R., R. Bucholz and V. Mooney. Porous hydroxyapatite as a bone graft substitute in metaphyseal defects: a histometric study. J. Bone Joint Surg. 68A: 904-915, 1986.
9. Kocialkowski, A., W. A. Wallace and R.G. Burwell. Collagraft combined with autogeneic bone marrow: experimental and clinical results. In: M.R. Urist, B.T. O'Connor and R.G. Burwell (ed.) Bone Grafts, Derivatives and Substitutes. B.H. Ltd., 1994, pp. 271-290.
10. Lin, F.H., C.H. Yao, C.W. Huang, H.C. Liu and J.S. Sun. The bonding behavior of the DP-bioglass and bone tissue. Mater. Chem. Phys. 46: 36-42, 1996.
11. Lin, F.H., C.H. Yao, J.S. Sun, H.C. Liu and C.W. Huang, Biological effects and cytotoxicity of the composite composed by tricalcium phosphate and glutaraldehyde cross-linked gelatin. Biomaterials 19: 905-917, 1998.
12. 5. J. Biomed. Eng. 13: 328-334, 1991a.
13. 3 system. J. Biomed. Eng. 13: 328-334, 1991b.
14. Manson, P.N., W.A. Crawley and J.E. Hoopes. Frontal cranioplasty: risk factors and choice of cranial vault reconstructive material. Plast. Reconstr. Surg. 77: 888-900, 1986.
15. Ono, K.T., Yamamuro, T. Nakamura, Y. Kakutani, T. Kitsugi, K. Hyakuna, T. Kokubo, M. Oka and Y. Kotoura. Apatite-wollastonite containing glass ceramic-fibrin mixture as a bone defect filler. J. Biomed. Mater. Res. 22: 869-885, 1988.
16. Rawling, C.E III, R.H. Wilkins and J.S. Hanker. Evaluation in cats of new material for cranioplasty: a composite of plaster of paris and hydroxyapatite. J. Neurosurg. 69: 269-275, 1988.
17. Ricci, J.L., N.C. Blumenthal, J.M. Spivak and H. Alexander. Evaluation of a low calcium phosphate paniculate implant material: physical-chemical properties and in vivo bone response. J. Oral Maxillofac. Surg. 50: 969-978, 1992.
18. Schmitz J.P. and J.O. Hollinger. The critical size defect as an experimental model for craniomandibulofacial nonunions. Clin. Ortho. Rel. Res. 20: 365-368, 1975.
19. TenHuisen, K.S., R.I. Martin, M. Klimkiewicz and P. W. Brown. Formation and properties of a synthetic bone composite: hydroxyapatite-collagen. J. Biomed. Mater. Res. 29: 803-810, 1995.
20. Tomford, W.W. and H.J. Mankin. Massive bone allografts. In: M.R. Urist, B.T. O'Connor and R.G. Burwell (ed.) Bone Grafts, Derivatives and Substitutes. B.H. Ltd., 1994, pp. 188-192.
21. Verheyen, C.C.P.M., J.R. de Wijn, C. A. van Blitterswijk, K. de Groot and P.M. Rozing. Hydroxyapatite/poly(L-lactide) composite: an animal study on push-out strengths and interface histology. J. Biomed. Mater. Res. 27: 433-444, 1993.