High response rates and lasting remissions after low-dose involved field radiotherapy in indolent lymphomas

Journal of Clinical Oncology

Volumn 21, Issue 13, 2003, Pages 2474-2480

  Haas, R L M ^a   Poortmans, Ph ^a   De Jong, D ^a   Aleman, B M P ^a   Dewit, L G H ^a   Verheij, M ^a   Hart, A A M ^a   Van Oers, M H J ^a   Van Der Hulst, M ^a   Baars, J W ^a   Bartelink, H ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; CANCER GRADING; CANCER GROWTH; CANCER RECURRENCE; CANCER REGRESSION; CONTROLLED STUDY; FEMALE; FOLLICULAR LYMPHOMA; HUMAN; LYMPHOMA; LYMPHOPLASMACYTOID LYMPHOMA; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RADIATION DOSE; RADIATION FIELD; TREATMENT RESPONSE; TUMOR VOLUME; B CELL LYMPHOMA; CANCER STAGING; CLINICAL TRIAL; DISEASE COURSE; MIDDLE AGED; PATHOLOGY; PHASE 2 CLINICAL TRIAL; RADIATION RESPONSE; SURVIVAL; TREATMENT OUTCOME;

ADULT; AGED; AGED, 80 AND OVER; DISEASE PROGRESSION; DOSE-RESPONSE RELATIONSHIP, RADIATION; FEMALE; HUMANS; LYMPHOMA, B-CELL; LYMPHOMA, FOLLICULAR; MALE; MIDDLE AGED; NEOPLASM STAGING; SURVIVAL; TREATMENT OUTCOME;

EID: 0038352170     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.2003.09.542     Document Type: Article

References (40)

1. Cartwright R, Brincker H, Carli PM, et al: The rise in incidence of lymphomas in Europe 1985-1992. Eur J Cancer 35:627-633, 1999
2. The International Non-Hodgkin's Lymphoma Prognostic Factors Project: A predictive model for aggressive non-Hodgkin's lymphoma. N Engl J Med 329:987-994, 1993
3. Portlock CS, Rosenberg SA, Glatstein E, et al: Management of low-grade non-Hodgkin's lymphomas. Semin Oncol 17:51-59, 1990
4. Lister TA, Cullen MH, Beard ME, et al: The management of follicular lymphoma. Ann Oncol 2:131-135, 1991
5. Kimby E, Bjorkholm M, Gahrton G, et al: Chlorambucil/prednisone vs. CHOP in symptomatic low-grade non-Hodgkin's lymphomas: A randomized trial from the Lymphoma Group of Central Sweden. Ann Oncol 5:67-71, 1994
6. Mendenhall NP, Lynch W: The low-grade lymphomas. Semin Radiat Oncol 5:254-266, 1995
7. Horning SJ: Treatment approaches to the low-grade lymphomas. Blood 83:881-884, 1994
8. Rohatiner AZS, Lister TA: New approaches to the treatment of follicular lymphoma. Br J Haematol 79:349-354, 1991
9. Portlock CS, Rosenberg SA: Combination chemotherapy with cyclophosphamide, vincristine and prednisone in advanced non-Hodgkin's lymphoma Cancer 37:1275-1280, 1976
10. Bishop JF, Wiernik PH, Wesley MN, et al: A randomised trial of high dose cyclophosphamide, vincristine, and prednisone plus or minus doxorubicin (CVP versus CAVP) with long-term follow-up in advanced non-Hodgkin's lymphoma. Leukaemia 1:508-513, 1987
11. Steward WP, Crowther D, McWilliam LJ, et al: Maintenance chlorambucil after CVP in the management of advanced stage, low-grade histologic type non-Hodgkin's lymphoma: A randomized prospective study with an assessment of prognostic factors. Cancer 61:441-447, 1988
12. Morrison VA, Peterson BA: Combination chemotherapy in the treatment of follicular low-grade lymphoma. Leuk Lymphoma 10:29-33, 1993 (suppl)
13. Hagenbeek A, Carde P, Meerwaldt JH, et al: Maintenance of remission with human recombinant interferon alfa-2a in patients with stages III and IV low-grade malignant non-Hodgkin's lymphoma: European Organization for Research and Treatment of Cancer Lymphoma Cooperative Group. J Clin Oncol 16:41-47, 1998
14. Chisesi T, Congiu M, Contu A, et al: Randomized study of chlorambucil (CB) compared to interferon (alpha-2b) combined with CB in low-grade non-Hodgkin's lymphoma: An interim report of a randomized study. Eur J Cancer 27:31-33, 1991
15. Knospe WH, Loeb V Jr: Biweekly chlorambucil treatment of lymphocytic lymphoma. Cancer Clin Trials 3:329-336, 1980
16. Gupta RK, Lister TA: Current management of follicular lymphoma. Curr Opin Oncol 8:360-365, 1996
17. Stolzenbach G, Garbrecht M: Intermittent combination chemotherapy with chlorambucil and prednisone of low-grade malignant non-Hodgkin's lymphomas according to the Kiel classification. J Cancer Res Clin Oncol 93:189-194, 1979
18. Cadman E, Drislane F, Waldron JA Jr, et al: High-dose pulse chlorambucil: Effective therapy for rapid remission induction in nodular lymphocytic poorly differentiated lymphoma. Cancer 50:1037-1041, 1982
19. Joseph G, Hadley T, Djulbegovic B, et al: High-dose chlorambucil and dexamethasone for relapsed non-Hodgkin's lymphomas. Am J Clin Oncol 16:319-322, 1993
20. Lister TA, Cullen MH, Beard ME, et al: Comparison of combined and single-agent chemotherapy in non-Hodgkin's lymphoma of favourable histological type. BMJ 6112:533-537, 1979
21. Hayhoe FG: Chemotherapy in the management of stage III/IV grade I non-Hodgkin's lymphomas (report no 17). Clin Radiol 32:547-552, 1981
22. Portlock CS, Rosenberg SA, Glatstein E, et al: Treatment of advanced non-Hodgkin's lymphomas with favourable histologies: Preliminary results of a prospective trial. Blood 47:747-756, 1976
23. Delic J, Magdelenat H, Barbaroux C, et al: In vivo induction of apoptosis in human lymphocytes by therapeutic fractionated total body irradiation. Br J Radiol 68:997-1003, 1995
24. Joiner MC, Lambin P, Malaise EP, et al: Hypersensitivity to very-low single radiation doses. Mutat Res 358:171-183, 1996
25. Minehan KJ, Martenson JA Jr., Garrity JA, et al: Local control and complications after radiation therapy for primary orbital lymphoma: a case for low-dose treatment. Int J Radiat Oncol Biol Phys 20:791-796, 1991
26. MacManus MP, Hoppe RT: Is radiotherapy curative for stage I and II low-grade follicular lymphoma? J Clin Oncol 14:1282-1290, 1996
27. Meerwaldt JH, Carde P, Burgers JM, et al: Low-dose total body irradiation versus combination chemotherapy for lymphomas with follicular growth pattern. Int J Radiat Oncol Biol Phys 21:1167-1172, 1991
28. De Neve WJ, Lybeert ML, Meerwaldt JH: Low-dose total body irradiation in non-Hodgkin lymphoma: Short and long term toxicity and prognostic factor. Am J Clin Oncol 13:280-284, 1990
29. Lybeert ML, Meerwaldt JH, Deneve W: Long-term results of low dose total body irradiation for advanced non-Hodgkin lymphoma. Int J Radiat Oncol Biol Phys 13:1167-1172, 1987
30. Kaminski MS, Coleman CN, Colby TV, et al: Factors predicting survival in adults with stage I and II large-cell lymphoma treated with primary radiation therapy. Ann Intern Med 104:747-756, 1986
31. Sutcliffe SB, Gospodarowicz MK, Bush RS, et al: Role of radiation therapy in localized non-Hodgkin's lymphoma. Radiother Oncol 4:211-223, 1985
32. Jacobs P, King HS: A randomized prospective comparison of chemotherapy to total body irradiation as initial treatment for the indolent lymphoproliferative diseases. Blood 69:1642-1646, 1987
33. Girinsky T, Guillot-Vals D, Koscielny S, et al: A high and sustained response rate in refractory or relapsing low-grade lymphoma masses after low-dose radiation: analysis of predictive parameters of response to treatment. Int J Radiat Oncol Biol Phys 51:148-155, 2001
34. Ganem G, Lambin P, Socie G, et al: Potential role for low dose limited-field radiation therapy (2 × 2 Grays) in advanced low-grade non-Hodgkin's lymphomas. Hematol Oncol 12:1-8, 1994
35. Sawyer EJ, Timothy AR: Low dose palliative radiotherapy in low grade non-Hodgkin's lymphoma. Radiother Oncol 42:49-51, 1997
36. Johansson J, Specht L, Meijer J, et al: Phase II study of palliative low-dose local radiotherapy in disseminated indolent non-Hodgkin's lymphoma (INHL) and chronic lymphocytic leukemia (CLL). Eur J Cancer 37:S93, 2001. (abstr)
37. Johansson J, Specht L, Meijer J, et al: Phase II study of palliative low-dose local radiotherapy in disseminated indolent non-Hodgkin's lymphoma (INHL) and chronic lymphocytic leukemia (CLL). Int J Radiat Oncol Biol Phys 51:361-362, 2001. (abstr)
38. Lossos IS, Alizadeh AA, Diehn M, et al: Transformation of follicular lymphoma to diffuse large-cell lymphoma: Alternative patterns with increased or decreased expression of c-myc and its regulated genes. Proc Natl Acad Sci U S A 99:8886-8891, 2002
39. Cole BF, Solal-Celigny P, Gelber RD, et al: Quality-of-life-adjusted survival analysis of interferon alfa-2b treatment for advanced follicular lymphoma: An aid to clinical decision making. J Clin Oncol 16:2339-2344, 1998
40. Webster K, Cella D: Quality of life in patients with low-grade non-Hodgkin's lymphoma. Oncology 12:697-714, 1998