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Volumn 108, Issue 1, 2003, Pages 38-45

Engineered variants of human glutamic acid decarboxylase (GAD) and autoantibody epitope recognition

Author keywords

Autoantibodies; Autoimmune thyroid disease; Autoimmunity; Diabetes; Epitopes; Glutamic acid decarboxylase; Radioimmunoassay; Recombinant protein

Indexed keywords

AUTOANTIBODY; ENZYME VARIANT; EPITOPE; GLUTAMATE DECARBOXYLASE; HYBRID PROTEIN;

EID: 0038351786     PISSN: 15216616     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1521-6616(03)00061-5     Document Type: Article
Times cited : (10)

References (35)
  • 2
    • 0028929053 scopus 로고
    • Targeting of the 67-kDa isoform of glutamic acid decarboxylase to intracellular organelles is mediated by its interaction with the NH2-terminal region of the 65-kDa isoform of glutamic acid decarboxylase
    • Dirkx R.J., Thomas A., Li L., Lernmark A., Sherwin R.S., De Camilli P., Solimena M. Targeting of the 67-kDa isoform of glutamic acid decarboxylase to intracellular organelles is mediated by its interaction with the NH2-terminal region of the 65-kDa isoform of glutamic acid decarboxylase. J. Biol. Chem. 270:1995;2241-2246.
    • (1995) J. Biol. Chem. , vol.270 , pp. 2241-2246
    • Dirkx, R.J.1    Thomas, A.2    Li, L.3    Lernmark, A.4    Sherwin, R.S.5    De Camilli, P.6    Solimena, M.7
  • 3
    • 0023933925 scopus 로고    scopus 로고
    • Autoantibodies to glutamic acid decarboxylase in a patient with stiff-man syndrome, epilepsy, and type 1 diabetes mellitus
    • Solimena M., Folli F., Denis-Donini S., Comi G.C., Pozza G., De Camilli P., Vicari A.M. Autoantibodies to glutamic acid decarboxylase in a patient with stiff-man syndrome, epilepsy, and type 1 diabetes mellitus. N. Engl. J. Med. 318:1999;1012-1020.
    • (1999) N. Engl. J. Med. , vol.318 , pp. 1012-1020
    • Solimena, M.1    Folli, F.2    Denis-Donini, S.3    Comi, G.C.4    Pozza, G.5    De Camilli, P.6    Vicari, A.M.7
  • 5
    • 0028008978 scopus 로고
    • GAD autoantibodies in IDDM, stiff-man syndrome, and autoimmune polyendocrine syndrome type I recognize different epitopes
    • Björk E., Velloso L.A., Kämpe O., Karlsson F.A. GAD autoantibodies in IDDM, stiff-man syndrome, and autoimmune polyendocrine syndrome type I recognize different epitopes. Diabetes. 43:1994;161-165.
    • (1994) Diabetes , vol.43 , pp. 161-165
    • Björk, E.1    Velloso, L.A.2    Kämpe, O.3    Karlsson, F.A.4
  • 7
    • 0026667626 scopus 로고
    • Glutamic acid decarboxylase autoantibodies in preclinical insulin-dependent diabetes
    • De Aizpurua H.J., Wilson Y.M., Harrison L.C. Glutamic acid decarboxylase autoantibodies in preclinical insulin-dependent diabetes. Proc. Natl. Acad. Sci. USA. 89:1992;9841-9845.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 9841-9845
    • De Aizpurua, H.J.1    Wilson, Y.M.2    Harrison, L.C.3
  • 9
    • 0026632265 scopus 로고
    • Antibodies to glutamic acid decarboxylase discriminate major types of diabetes mellitus
    • Rowley M.J., Mackay I.R., Chen Q.Y., Knowles W.J., Zimmet P.Z. Antibodies to glutamic acid decarboxylase discriminate major types of diabetes mellitus. Diabetes. 41:1992;548-551.
    • (1992) Diabetes , vol.41 , pp. 548-551
    • Rowley, M.J.1    Mackay, I.R.2    Chen, Q.Y.3    Knowles, W.J.4    Zimmet, P.Z.5
  • 10
    • 0030695027 scopus 로고    scopus 로고
    • Prediction of IDDM in the general population: Strategies based on combinations of autoantibody markers
    • Bingley P.J., Bonifacio E., Williams A.J., Genovese S., Bottazzo G.F., Gale E.A. Prediction of IDDM in the general population strategies based on combinations of autoantibody markers . Diabetes. 46:1997;1701-1710.
    • (1997) Diabetes , vol.46 , pp. 1701-1710
    • Bingley, P.J.1    Bonifacio, E.2    Williams, A.J.3    Genovese, S.4    Bottazzo, G.F.5    Gale, E.A.6
  • 11
    • 0027510420 scopus 로고
    • Autoreactive epitopes defined by diabetes-associated human monoclonal antibodies are localized in the middle and C-terminal domains of the smaller form of glutamate decarboxylase
    • Richter W., Shi Y., Baekkeskov S. Autoreactive epitopes defined by diabetes-associated human monoclonal antibodies are localized in the middle and C-terminal domains of the smaller form of glutamate decarboxylase. Proc. Natl. Acad. Sci. USA. 90:1993;2832-2836.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 2832-2836
    • Richter, W.1    Shi, Y.2    Baekkeskov, S.3
  • 13
    • 0028928952 scopus 로고
    • Two distinct glutamic acid decarboxylase auto-antibody specificities in IDDM target different epitopes
    • Daw K., Powers A.C. Two distinct glutamic acid decarboxylase auto-antibody specificities in IDDM target different epitopes. Diabetes. 44:1995;216-220.
    • (1995) Diabetes , vol.44 , pp. 216-220
    • Daw, K.1    Powers, A.C.2
  • 14
    • 0030272748 scopus 로고    scopus 로고
    • Detection of glutamic acid decarboxylase (GAD) autoantibodies by indirect immunofluorescence using CHO cells expressing recombinant human GAD65
    • Papouchado M.L., Ermácora M.R., Poskus E. Detection of glutamic acid decarboxylase (GAD) autoantibodies by indirect immunofluorescence using CHO cells expressing recombinant human GAD65. J. Autoimmun. 9:1996;689-697.
    • (1996) J. Autoimmun. , vol.9 , pp. 689-697
    • Papouchado, M.L.1    Ermácora, M.R.2    Poskus, E.3
  • 15
    • 0030470633 scopus 로고    scopus 로고
    • Immune reactivity of diabetes-associated human monoclonal autoantibodies defines multiple epitopes and detects two domain boundaries in glutamate decarboxylase
    • Syren K., Lindsay L., Stoehrer B., Jury K., Lühder F., Baekkeskov S., Richter W. Immune reactivity of diabetes-associated human monoclonal autoantibodies defines multiple epitopes and detects two domain boundaries in glutamate decarboxylase. J. Immunol. 157:1996;5208-5214.
    • (1996) J. Immunol. , vol.157 , pp. 5208-5214
    • Syren, K.1    Lindsay, L.2    Stoehrer, B.3    Jury, K.4    Lühder, F.5    Baekkeskov, S.6    Richter, W.7
  • 16
    • 1842475975 scopus 로고    scopus 로고
    • Epitope spreading and a varying but not disease-specific GAD65 antibody response in Type 1 diabetes. The Childhood Diabetes in Finland Study Group
    • Sohnlein P., Muller M., Syren K., Hartmann U., Bohm B.O., Meinck H.M., Knip M., Akerblom H.K., Richter W. Epitope spreading and a varying but not disease-specific GAD65 antibody response in Type 1 diabetes. The Childhood Diabetes in Finland Study Group. Diabetologia. 43:2000;210-217.
    • (2000) Diabetologia , vol.43 , pp. 210-217
    • Sohnlein, P.1    Muller, M.2    Syren, K.3    Hartmann, U.4    Bohm, B.O.5    Meinck, H.M.6    Knip, M.7    Akerblom, H.K.8    Richter, W.9
  • 17
    • 0030028799 scopus 로고    scopus 로고
    • Glutamic acid decarboxylase autoantibodies in stiff-man syndrome and insulin-dependent diabetes mellitus exhibit similarities and differences in epitope recognition
    • Daw K., Ujihara N., Atkinson M., Powers A.C. Glutamic acid decarboxylase autoantibodies in stiff-man syndrome and insulin-dependent diabetes mellitus exhibit similarities and differences in epitope recognition. J. Immunol. 156:1996;818-825.
    • (1996) J. Immunol. , vol.156 , pp. 818-825
    • Daw, K.1    Ujihara, N.2    Atkinson, M.3    Powers, A.C.4
  • 18
    • 0032716704 scopus 로고    scopus 로고
    • Comparative analysis of epitope recognition of glutamic acid decarboxylase (GAD) by autoantibodies from different autoimmune disorders
    • Powers A.C., Bavik K., Tremble J., Daw K., Scherbaum W.A., Banga J.P. Comparative analysis of epitope recognition of glutamic acid decarboxylase (GAD) by autoantibodies from different autoimmune disorders. Clin. Exp. Immunol. 118:1999;349-356.
    • (1999) Clin. Exp. Immunol. , vol.118 , pp. 349-356
    • Powers, A.C.1    Bavik, K.2    Tremble, J.3    Daw, K.4    Scherbaum, W.A.5    Banga, J.P.6
  • 19
    • 0029793724 scopus 로고    scopus 로고
    • Diagnostic sensitivity of immunodominant epitopes of glutamic acid decarboxylase (GAD65) autoantibodies in childhood IDDM
    • Falorni A., Ackefors M., Carlberg C., Daniels T., Persson B., Robertson J., Lernmark A. Diagnostic sensitivity of immunodominant epitopes of glutamic acid decarboxylase (GAD65) autoantibodies in childhood IDDM. Diabetologia. 39:1996;1091-1098.
    • (1996) Diabetologia , vol.39 , pp. 1091-1098
    • Falorni, A.1    Ackefors, M.2    Carlberg, C.3    Daniels, T.4    Persson, B.5    Robertson, J.6    Lernmark, A.7
  • 20
    • 0032415715 scopus 로고    scopus 로고
    • Autoantigenic reactivity of diabetes sera with a hybrid glutamic acid decarboxylase GAD67-65 molecule GAD67 (1-101)/GAD65(96-585)
    • Teoh K.L., Fida S., Rowley M.J., Mackay I.R. Autoantigenic reactivity of diabetes sera with a hybrid glutamic acid decarboxylase GAD67-65 molecule GAD67 (1-101)/GAD65(96-585). Autoimmunity. 28:1998;259-266.
    • (1998) Autoimmunity , vol.28 , pp. 259-266
    • Teoh, K.L.1    Fida, S.2    Rowley, M.J.3    Mackay, I.R.4
  • 22
    • 0033964008 scopus 로고    scopus 로고
    • Maturation of the humoral autoimmune response to epitopes of GAD in preclinical childhood type 1 diabetes
    • Bonifacio E., Lampasona V., Bernasconi L., Ziegler A.G. Maturation of the humoral autoimmune response to epitopes of GAD in preclinical childhood type 1 diabetes. Diabetes. 49:2000;202-208.
    • (2000) Diabetes , vol.49 , pp. 202-208
    • Bonifacio, E.1    Lampasona, V.2    Bernasconi, L.3    Ziegler, A.G.4
  • 26
    • 0031006826 scopus 로고    scopus 로고
    • Expression of properly folded human glutamate decarboxylase 65 as a fusion protein in Escherichia coli
    • Papouchado M.L., Valdez S.N., Ghiringhelli D., Poskus E., Ermácora M.R. Expression of properly folded human glutamate decarboxylase 65 as a fusion protein in Escherichia coli. Eur. J. Biochem. 246:1997;350-359.
    • (1997) Eur. J. Biochem. , vol.246 , pp. 350-359
    • Papouchado, M.L.1    Valdez, S.N.2    Ghiringhelli, D.3    Poskus, E.4    Ermácora, M.R.5
  • 30
    • 0028216264 scopus 로고
    • Amino acid residues 24-31 but not palmitoylation of cysteines 30 and 45 are required for membrane anchoring of glutamic acid decarboxylase, GAD65
    • Shi Y., Veit B., Baekkeskov S. Amino acid residues 24-31 but not palmitoylation of cysteines 30 and 45 are required for membrane anchoring of glutamic acid decarboxylase, GAD65. J. Cell. Biol. 124:1994;927-934.
    • (1994) J. Cell. Biol. , vol.124 , pp. 927-934
    • Shi, Y.1    Veit, B.2    Baekkeskov, S.3
  • 32
    • 0028132553 scopus 로고
    • Identification of glutamic acid decarboxylase autoantibody heterogeneity and epitope regions in type 1 diabetes
    • Ujihara N., Daw K., Gianani R., Boel E., Yu L., Powers A.C. Identification of glutamic acid decarboxylase autoantibody heterogeneity and epitope regions in type 1 diabetes. Diabetes. 43:1994;968-975.
    • (1994) Diabetes , vol.43 , pp. 968-975
    • Ujihara, N.1    Daw, K.2    Gianani, R.3    Boel, E.4    Yu, L.5    Powers, A.C.6
  • 33
    • 0028911293 scopus 로고
    • High diagnostic sensitivity of glutamate decarboxylase autoantibodies in insulin-dependent diabetes mellitus with clinical onset between age 20 and 40 years. The Belgian Diabetes Registry
    • Vandewalle C.L., Falorni A., Svanholm S., Lernmark A., Pipeleers D.G., Gorus F.K. High diagnostic sensitivity of glutamate decarboxylase autoantibodies in insulin-dependent diabetes mellitus with clinical onset between age 20 and 40 years. The Belgian Diabetes Registry. J. Clin. Endocrinol. Metab. 80:1995;846-851.
    • (1995) J. Clin. Endocrinol. Metab. , vol.80 , pp. 846-851
    • Vandewalle, C.L.1    Falorni, A.2    Svanholm, S.3    Lernmark, A.4    Pipeleers, D.G.5    Gorus, F.K.6
  • 34
    • 0033011970 scopus 로고    scopus 로고
    • Crucial points at diagnosis. Type 2 diabetes or slow type 1 diabetes
    • Zimmet P., Turner R., McCarty D., Rowley M., Mackay I. Crucial points at diagnosis. Type 2 diabetes or slow type 1 diabetes. Diabetes Care. 22:(Suppl 2):1999;B59-64.
    • (1999) Diabetes Care , vol.22 , Issue.SUPPL. 2 , pp. 59-64
    • Zimmet, P.1    Turner, R.2    McCarty, D.3    Rowley, M.4    Mackay, I.5
  • 35
    • 0030049844 scopus 로고    scopus 로고
    • Islet cell and glutamic acid decarboxylase antibodies in hyperthyroid patients: At diagnosis and following treatment
    • Hallengren B., Falorni A., Landin-Olsson M., Lernmark A., Papadopoulos K.I., Sundkvist G. Islet cell and glutamic acid decarboxylase antibodies in hyperthyroid patients at diagnosis and following treatment . J. Intern. Med. 239:1996;63-68.
    • (1996) J. Intern. Med. , vol.239 , pp. 63-68
    • Hallengren, B.1    Falorni, A.2    Landin-Olsson, M.3    Lernmark, A.4    Papadopoulos, K.I.5    Sundkvist, G.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.