Oscillations of pH inside the secretory granule control the gain of Ca2+ release for signal transduction in goblet cell exocytosis

Novartis Foundation Symposium

Volumn 248, Issue , 2002, Pages 132-149

  Chin, Wei Chun ^b   Quesada, Ivan ^a   Nguyen, Thuc ^a   Verdugo, Pedro ^a  

^a University of Washington   (United States)

^b FLORIDA A AND M UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ACTIVATED POTASSIUM CHANNEL; CALCIUM CHANNEL; CELL RECEPTOR; INOSITOL 1,4,5 TRISPHOSPHATE; MUCIN;

ANIMAL; ARTICLE; BIOLOGICAL MODEL; CALCIUM SIGNALING; CELL GRANULE; CHEMISTRY; CYTOLOGY; DRUG EFFECT; EXOCRINE GLAND; EXOCYTOSIS; ION TRANSPORT; MACROMOLECULE; METABOLISM; MUCUS; PH; PHYSIOLOGY; SECRETION;

ANIMALS; CALCIUM CHANNELS; CALCIUM SIGNALING; CYTOPLASMIC GRANULES; EXOCRINE GLANDS; EXOCYTOSIS; HYDROGEN-ION CONCENTRATION; INOSITOL 1,4,5-TRISPHOSPHATE; ION TRANSPORT; MACROMOLECULAR SUBSTANCES; MODELS, BIOLOGICAL; MUCINS; MUCUS; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; RECEPTORS, CYTOPLASMIC AND NUCLEAR;

EID: 0038349998     PISSN: None     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Article

References (28)

1. Barasch J, Gershon MD, Nunez EA, Tamir H, al-Awqati Q 1988 Thyrotropin induces the acidification of the secretory granules of parafollicular cells by increasing the chloride conductance of the granular membrane. J Cell Biol 107:2137-2147
2. Barasch J, Kiss B, Prince A, Saiman L, Gruenert D, al-Awqati Q 1991 Defective acidification of intracellular organelles in cystic fibrosis. Nature 352:70-73
3. de Gennes PG, Leger L 1982 Dynamics of entangled polymer chains. Annu Rev Phys Chem 33:49-61
4. Edwards SF 1986 The theory of macromolecular networks. Biorheology 23:589-603
5. Forstner JF, Forstner GG 1975 Calcium binding to intestinal goblet cell mucin. Biochim Biophys Acta 386:283-292
6. 2+ from single isolated pancreatic zymogen granules. Cell 84:473-480
7. Gerdes HH, Rosa P, Phillips E et al 1989 The primary structure of human secretogranin II, a widespread tyrosine-sulfated secretory granule protein that exhibits low pH- and calcium-induced aggregation. J Biol Chem 264:12009-12015
8. Hutton JC 1982 The internal pH and membrane potential of the insulin-secretory granule. Biochem J 204:171-178
9. Hutton JC, Penn EJ, Peshavaria M 1983 Low-molecular-weight constituents of isolated insulin-secretory granules. Bivalent cations, adenine nucleotides and inorganic phosphate. Biochem J 210:297-305
10. Johnson RG, Pfister D, Carty SE, Scarpa A 1979 Biological amine transport in chromaffin ghosts. Coupling to the transmembrane proton and potential gradients. J Biol Chem 254:10963-10972
11. 2+] with fluorescent probes. In: Nuccitelli R (ed) A practical guide to the study of calcium in living cells. Academic Press, San Diego, p 155-181
12. Katchalsky A, Lifson S, Eisenberg HJ 1951 Equation of swelling of polyelectrolyte gels. J Polym Sci 7:571-574
13. Meldolesi J, Pozzan T 1995 IP3 receptors and secretory granules. Trends Neurosci 18:340-341.
14. 2+ participates in the catalysis of exocytosis. J Biol Chem 275:9136-9142
15. 2+. Nature 395:908-912
16. Quesada I, Chin WC, Steed J, Campos-Bedolla P, Verdugo P 2001 Mouse mast cell secretory granules can function as intracellular ionic oscillators. Biophys J 80:2133-2139
17. 2+ depletion from granules inhibits exocytosis. A study with insulin-secreting cells. J Biol Chem 273:19002-19008
18. Tanaka T 1981 Gels. Sci Am 244:124-138
19. Tanaka T, Fillmore D, Sun ST, Nishio I, Swislow G, Shah A 1980 Phase transitions in ionic gels. Phys Rev Lett 45:1636-1639
20. Thirion S, Troadec JD, Pivovarova NB et al 1999 Stimulus-secretion coupling in neurohypophyseal nerve endings: a role for intravesicular sodium? Proc Nad Acad Sci USA 96:3206-3210
21. Uvnas B, Aborg CH 1977 On the cation exchanger properties of rat mast cell granules and their storage of histamine. Acta Physiol Scand 100:309-314
22. Uvnas B, Aborg CH 1989 Role of ion exchange in release of biogenic amines. News in Physiol Sci 4:68-71
23. Verdugo P 1990 Goblet cells secretion and mucogenesis. Annu Rev Physiol 52:157-176
24. Verdugo P 1994 Polymer gel phase transition in condensation-decondensation of secretory products. Adv Poly Sci 110:145-156
25. Williams RM, Webb WW 2000 Single granule pH cycling in antigen-induced mast cell secretion. J Cell Sci 113:3839-3850
26. Wu MM, Grabe M, Adams S, Tsien RY, Moore HP, Machen TE 2001 Mechanisms of pH regulation in the regulated secretory pathway. J Biol Chem 276:33027-33035
27. 2+ release from bovine adrenal medullary secretory vesicles. J Biol Chem 265:13446-13448
28. 2+ storage proteins chromogranins A and B. J Biol Chem 276:45806-45812