Comparison of the efficacy and tolerability of topically administered azelastine, sodium cromoglycate and placebo in the treatment of seasonal allergic conjunctivitis and rhinoconjunctivitis

Current Medical Research and Opinion

Volumn 19, Issue 4, 2003, Pages 313-320

  James, I G V ^a   Campbell, L M ^a   Harrison, J M ^b   Fell, P J ^b   Ellers Lenz, B ^c   Petzold, U ^c  

^a Southbank Surgery   (United Kingdom)

^b Acland Hospital   (United Kingdom)

^c Viatris Inc   (Germany)

Author keywords

Allergic rhino conjunctivitis; Antiallergic drugs; Azelastine; H1antagonists; Sodium cromoglycate; Topical antihistamines

Indexed keywords

AZELASTINE; CROMOGLYCATE DISODIUM; EYE DROPS; PLACEBO;

ADULT; AGED; ALLERGIC CONJUNCTIVITIS; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG TOLERABILITY; EYELID DISEASE; FEMALE; FOREIGN BODY; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; OCULAR PRURITUS; PATIENT SATISFACTION; PHARYNGITIS; PHOTOPHOBIA; RANDOMIZED CONTROLLED TRIAL; RHINOCONJUNCTIVITIS; SCORING SYSTEM; SIDE EFFECT; TASTE DISORDER; TEAR FLOW; TINNITUS; TREATMENT OUTCOME;

ADMINISTRATION, TOPICAL; ADOLESCENT; ADULT; AGED; ANTI-ALLERGIC AGENTS; ANTI-ASTHMATIC AGENTS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CONJUNCTIVITIS, ALLERGIC; CROMOLYN SODIUM; DOUBLE-BLIND METHOD; FEMALE; HISTAMINE H1 ANTAGONISTS; HUMANS; MALE; MIDDLE AGED; OPHTHALMIC SOLUTIONS; PHTHALAZINES; RHINITIS, ALLERGIC, SEASONAL;

EID: 0038343109     PISSN: 03007995     EISSN: None     Source Type: Journal    
DOI: 10.1185/030079903125001785     Document Type: Article

References (18)

1. Bahmer FA. Topical levocabastine - an effective alternative to oral antihistamines in seasonal allergic rhino-conjunctivitis. Clin Exp Allergy 1995;25:220-7
2. Chand N. Antagonism of histamine and leukotrienes by azelastine in isolated guinea pig ileum. Agents Actions 1986;19(3/4):164-8
3. Achterrath-Tuckerman U, Weischer CH, Szelenyi I. Azelastine, a new antiallergic/antiasthmatic agent, inhibits PAF-acether-induced platelet aggregation, paw oedema and bronchoconstriction. Pharmacology 1988;36:265-71
4. Ciprandi G, Pronzato C, Passalacqua G, Ricca V, Bagnasco M, Grögen J, Mela GS, Canonica GW. Topical azelastine reduces eosinophil activation and intercellular adhesion molecule-1 expression on nasal epithelial cells: an antiallergic activity. J Allergy Clin Immunol 1996;98:1088-96
5. McTavish D, Sorkin EM. Azelastine: a review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential. Drugs 1989;38(5):778-800
6. Giede-Tuch C, Westhoff M, Zarth A. Azelastine eye drops in seasonal allergic conjunctivitis or rhino-conjunctivitis. Allergy 1998;53:857-62
7. Lenhard G, Mivsek-Music E, Perrin-Fayolle M, Obtulowicz K, Secchi A. Double-blind, randomised, placebo-controlled study of two concentrations of azelastine eye drops in seasonal allergic conjunctivitis or rhino-conjunctivitis. Curr Med Res Opin 1997;14:21-8
8. Giede C, Metzenauer P, Petzold, U. Comparison of azelastine eye drops with levocabastine eye drops in the treatment of seasonal allergic conjunctivitis. Curr Med Res Opin 2000;16:153-63
9. Sabbah A, Marzetto, M. Azelastine eye drops in the treatment of seasonal allergic conjunctivitis or rhino-conjunctivitis in young children. Curr Med Res Opin 1998;14:161-70
10. Ciprandi G, Buscaglia S, Catrullo A, Pesce G, Fiorino N, Montagna P, Bagnasco M, Canonica GW. Azelastine eye drops reduce and prevent allergic conjunctival reaction and exert antiallergic activity. Clin Exp Allergy 1997;27:182-91
11. Abelson MB, George MG, Schaefer K, Smith LM. Evaluation of the new ophthalmic antihistamine, 0.05% levocabastine, in the clinical allergen challenge model of allergic conjunctivitis. J Allergy Clin Immunol 1994;3:458-64
12. Allansmith MR, Ross RN. Ocular allergy. Rev Clin Allergy 1988;18:1-13
13. Leino M, Ennevaara K, Latvala A-L, Nordgren P, Posti A-M, Suves R, Takalo E. Double-blind group comparative study of 2% nedocromil sodium eye drops with 2% sodium cromoglycate and placebo eye drops in the treatment of seasonal allergic conjunctivitis. Clin Exp Allergy 1992;22:929-32
14. Davies BH, Mullins J. Topical levocabastine is more effective than sodium cromoglycate for the prophylaxis and treatment of seasonal allergic conjunctivitis. Allergy 1993;48:519-24
15. Brogden RN, Pinder RM, Sawyer PR, Speight TM, Avery GS. Beclomethasone diproprionate: II: Allergic rhinitis and other conditions. Drugs 1975;10:211-17
16. Howarth PH. A review of the tolerability and safety of levocabastine eye drops and nasal spray. Implications for patient management. Mediators I[nflamm 1995;4(Suppl):526-30
17. Sorkin EM, Ward A. Ocular sodium cromoglycate, an overview of its therapeutic efficacy in allergic eye disease. Drugs 1986;31:131-48
18. Blumenthal M, Casale T, Dockhorn R, Jarmoszuk I, Kaiser H, Smith R, Zeitz HJ. Efficacy and safety of nedocromil sodium ophthalmic solution in the treatment of seasonal allergic conjunctivitis. Am J Ophthalmol 1992;113:56-63