Benefits of intraluminal injection of glutamine for intestinal mucosa during ischemia-reperfusion

European Surgical Research

Volumn 35, Issue 4, 2003, Pages 352-356

  De Aguilar Nascimento, José Eduardo ^a,b   Marques, Cláudia Gurgel ^a   Mariano, Alessandra Carvalho ^a   Bicudo Salomao A ^a   De Souza Neves, J ^a  

^a University of Mato Grosso   (Brazil)

^b NONE   (Brazil)

Author keywords

Glutamine; Ischemia; Mucosa; Neutrophils; Reperfusion; Small intestine

Indexed keywords

GLUTAMINE; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL MIGRATION; CONTROLLED STUDY; ILEUM; INTESTINE ISCHEMIA; JEJUNUM; LAMINA PROPRIA; MUCOSAL IMMUNITY; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION; SMALL INTESTINE; VASCULARIZATION;

ANIMALS; DISEASE MODELS, ANIMAL; GLUTAMINE; ILEUM; INTESTINAL MUCOSA; JEJUNUM; LEUKOCYTE COUNT; NEUTROPHILS; RATS; RATS, WISTAR; REPERFUSION INJURY;

EID: 0038308507     PISSN: 0014312X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000070606     Document Type: Article

References (21)

1. Kong SE, Blennerhassett LR, Heel KA, McCauley RD, Hall JC: Ischemia-reperfusion injury to the intestine. Aust NZ J Surg 1998;68:554-561.
2. Harward TRS, Coe D, Souba WW, Kingman N, Seeger JM: Glutamine preserves gut glutathione levels during intestinal ischemia/reperfusion. J Surg Res 1994;56:351-355.
3. Parks DA, Williams TK, Beckman JS: Conversion of xanthine dehydrogenase to oxidase in ischemic rat intestine: A re-evaluation. Am J Physiol 1988;254:G768-G774.
4. Grotz MR, Deitch EA, Ding J, Xu D, Huang Q, Regel G: Intestinal cytokine response after gut ischemia: Role of gut barrier failure. Ann Surg 1999;229:478-486.
5. Saito H, Furukawa S, Matsuda T: Glutamine as an immunoenhancing nutrient. JPEN J Parenter Enteral Nutr 1999;23(5 suppl):S59-S61.
6. Gibson DD, Brackett DJ, Squires RA, Balla AK, Lerner MR, McCay PB, Pennington LR: Evidence that the large loss of glutathione observed in ischemia/reperfusion of the small intestine is not due to oxidation to glutathione disulfide. Free Radic Biol Med 1993;14:427-433.
7. Chiu C, McArdle AH, Brown R, Scott HJ, Gurd FN: Intestinal mucosal lesion in low-flow states. Arch Surg 1970;101:478-483.
8. Gangadharan SP, Wagner RJ, Cronenwett JL: Effect of intravenous glucagon on intestinal viability after segmental mesenteric ischemia. J Vasc Surg 1995;21:900-908.
9. Quaedackers JSLT, Beuk RJ, Bennet L, Charlton A, Egbrink MGA, Jun AJ, Heineman E: An evaluation of methods for grading histologic injury following ischemia/reperfusion of the small bowel. Transplant Proc 2000;32:1307-1310.
10. Kanwar S, Kubes P: Mast cells contribute to ischemia-reperfusion-induced granulocyte infiltration dysfunction. Am J Physiol 1994;267:G316-G321.
11. Granger DN: Role of xanthine oxidase and granulocytes in ischemia-reperfusion injury. Am J Physiol 1988;255:H1269-H1275.
12. Kubes P, Hunter J, Granger DN: Ischemia/reperfusion-induced feline intestinal dysfunction: Importance of granulocyte recruitment. Gastroenterology 1992;103:807-812.
13. Zhi-Yong S, Dong YL, Wang XH: Bacterial translocation and multiple system organ failure in bowel ischemia and reperfusion. J Trauma 1992;32:148-153.
14. Schoenberg MH, Beger HG: Oxygen radicals in intestinal ischemia and reperfusion. Chem Biol Interact 1990;76:141-161.
15. Martenssen J, Jain A, Meister A: Glutathione is required for intestinal function. Proc Natl Acad Sci USA 1990;87:1715-1719.
16. Souba WW, Smith RJ, Wilmore DW: Glutamine metabolism by the intestinal tract. JPEN J Parenter Enteral Nutr 1985;9:608-617.
17. Lew JI, Zhang W, Koide S, Smith RJ, Rombeau JL: Glutamine improves cold-preserved small bowel graft structure and function following ischemia and reperfusion. Transplant Proc 1996;28:2605-2606.
18. Sasaki K, Hirata K, Zou XM, Sakawaki T, Yagihashi A, Tsuruma T, Katsuramaki T, Koide S, Zhang W, Rombeau JL: Optimum small bowel preservation solutions and conditions: Comparison of UW solution and saline with or without glutamine. Transplant Proc 1996;28:2620-2621.
19. Gundlach M, Pohland CCJ, Toennies SE, Knoefel WT, Rogiers X, Broelsch CE: Small bowel preservation: Evaluation of different solutions. Transplant Proc 1996;28:2622-2623.
20. Zhang W, Frankel WL, Bain A, Choi D, Klurfeld DM, Rombeau JL: Glutamine reduces bacterial translocation after small bowel transplantation in cyclosporine-treated rats. J Surg Res 1995;58:159-164.
21. Cicalese L, Sileri P, Green M, Abu-Elmagd K, Kocoshis S, Reyes J: Bacterial translocation in clinical intestinal transplantation. Transplantation 2001;71:1414-1417.