A new approach to the 2,5-diamino-5,6-dihydro-1H-pyrimidine-4-one derivatives: Synthesis of TAN-1057A/B and analogs

Tetrahedron Letters

Volumn 44, Issue 31, 2003, Pages 5871-5873

  Zhang, Lijun ^a   Xu, Lianhong ^a   Kim, Choung U ^a  

^a GILEAD SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; DRUG ANALOG; KETONE DERIVATIVE; PYRIMIDINE DERIVATIVE; TAN 1057 A; TAN 1057 B; UNCLASSIFIED DRUG;

ARTICLE; BACTERICIDAL ACTIVITY; CHEMICAL REACTION; DRUG SYNTHESIS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; QUANTUM YIELD;

EID: 0038306715     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(03)01381-9     Document Type: Article

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10. 3) δ: 1.4 (brs, 9H), 2.8 (brs, 3H), 2.9 (brs, 3H), 3.35 (m, 1H), 3.7 (m, 1H), 4.5 (m, 2H), 5.05 (m, 1H), 7.2-7.4 (m, 5H). MS (M+1): 347.
11. Both analogs 2 and 3 displayed reduced minimal inhibitory concentration (MIC) against Staphylococci, data are listed as follows: MIC, S. aureus 29213 (μg/mL): TAN-1057, 8; analog 2, >256; analog 3, 64.