Efficacy of local molsidomine delivery from a hydrogel-coated angioplasty balloon catheter in the atherosclerotic porcine model

CardioVascular and Interventional Radiology

Volumn 26, Issue 1, 2003, Pages 65-72

  Rolland, Pierre H ^a   Mekkaoui, Choukri ^a   Palassi, Maria ^c   Friggi, Alain ^a   Moulin, Guy ^a,b   Piquet, Philippe ^a,c   Bartoli, Jean Michel ^a,b  

^a AIX MARSEILLE UNIVERSITY   (France)

^b TIMONE HOSPITAL   (France)

^c BOSTON SCIENTIFIC CORPORATION   (United States)

Author keywords

Atherosclerotic pigs; Drug delivery systems; Iliac angioplasty; Local drug delivery; Nitric oxide donors; Restenosis

Indexed keywords

LINSIDOMINE; MOLSIDOMINE; NITRIC OXIDE; PLACEBO; VASODILATOR AGENT;

ADVENTITIA; ANGIOPLASTY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY MEDIA; ARTERY WALL; ARTICLE; ATHEROGENIC DIET; ATHEROSCLEROSIS; BALLOON CATHETER; CELL PROLIFERATION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; HISTOPATHOLOGY; HOMEOSTASIS; HYDROGEL; ILIAC ARTERY; ILIAC VEIN; MORPHOMETRICS; NONHUMAN; PRIORITY JOURNAL; PULSE WAVE; RESTENOSIS; THROMBOCYTE AGGREGATION; VASODILATATION; ANALYSIS OF VARIANCE; ANIMAL; ARTERIOSCLEROSIS; DISEASE MODEL; INSTRUMENTATION; NONPARAMETRIC TEST; PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY; SCANNING ELECTRON MICROSCOPY; SWINE;

ANALYSIS OF VARIANCE; ANGIOPLASTY, BALLOON; ANIMALS; ARTERIOSCLEROSIS; DISEASE MODELS, ANIMAL; DRUG DELIVERY SYSTEMS; HYDROGEL; ILIAC ARTERY; MICROSCOPY, ELECTRON, SCANNING; MOLSIDOMINE; STATISTICS, NONPARAMETRIC; SWINE; VASODILATOR AGENTS;

EID: 0038305671     PISSN: 01741551     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00270-002-1940-y     Document Type: Article

References (43)

1. Tetteroo E, Vandergraaf Y, Bosch JL, Vanengelen AD, Hunink MGM, Eikelboom BC, Mali WPTM (1998) Randomised comparison of primary stent placement versus primary angioplasty followed by selective stent placement in patients with iliac-artery occlusive disease. Dutch Iliac Stent Trial Study Group. Lancet 351:1153-1159
2. Hart CE, Kraiss LW, Vergel S, Gilbertson D, Kenagy R, Kirkman T, Crandall DL, Tickle S, Finney H, Yarranton G, Clowes AW (1999) PDGF beta receptor blockade inhibits intimal hyperplasia in the baboon. Circulation 99:564-569
3. Becquemin JP, Allaire E, Qvarfordt P, Desgranges P, Kobeiter H, Melliere D (1999) Surgical transluminal iliac angioplasty with selective stenting: Long-term results assessed by means of duplex scanning. J Vasc Surg 29:422-429
4. Wilensky RL, Tanguay JF, Ito S, Bartorelli AL, Moses J, Williams DO, Bailey SR, Martin J, Bucher TA, Gallant P, Greenberg A, Popma JJ, Weissman NJ, Mintz GS, Kaplan AV, Leon MB (2000) Heparin infusion prior to stenting (HIPS) trial: Final results of a prospective, randomized, controlled trial evaluating the effects of local vascular delivery on intimal hyperplasia. Am Heart J 139:1061-1070
5. Johnson MS, Bergmann CA, Carmody TJ, Dreesen RG, Barry JJ, Barina C, Orazi A, Ambrosius WT (2000) Local delivery of nadroparin via hydrogel-coated angioplasty balloon: Effect on platelet deposition and smooth muscle cell proliferation-an experimental study. J Vasc Interv Radiol 11:115-122
6. Brieger D, Topol E (1997) Local drug delivery systems and prevention of restenosis. Cardiovasc Res 35:405-413
7. Consigny PM, Barry JJ, Vitali NJ (1994) Local delivery of an antiproliferative drug with use of hydrogel-coated angioplasty balloons. J Vasc Interv Radiol 5:553-560
8. Geary RL, Adams MR, Benjamin ME, Williams JK (1998) Conjugated equine estrogens inhibit progression of atherosclerosis but have no effect on intimal hyperplasia or arterial remodeling induced by balloon catheter injury in monkeys. J Am Coll Cardiol 31:1158-1164
9. Kandarpa K, Nakatsuka S, Yousuf N, Barry JJ (1998) Site-specific delivery of iloprost during experimental angioplasty suppresses smooth muscle cell proliferation. J Vasc Interv Radiol 9:487-493
10. Azrin MA, Mitchell JF, Fram DB, Pedersen CA, Cartun RW, Barry JJ, Bow LM, Waters DD, McKay RG (1994) Decreased platelet deposition and smooth muscle cell proliferation after intramural heparin delivery with hydrogel-coated balloons. Circulation 90:433-441
11. Palasis M, Luo Z, Barry J, Walsh K (2000) Analysis of adenoviral transport mechanisms in the vessel wall and optimization of gene transfer using local delivery catheters. Hum Gene Ther 11:237-246
12. Garg UC, Hassid A (1989) Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J Clin Invest 83:1774-1777
13. Sarkar R, Meinberg EG, Stanley JC, Gordon D, Webb RC (1996) Nitric oxide reversibly inhibits the migration of cultured vascular smooth muscle cells. Circulation 78:225-230
14. Latrille V, Ghiringhelli O, Jourdheuil-Rahmani D, Barlatier A, Bodard H, Charpiot P, Guillou J, Luccioni R, Garçon D, Rolland PH (1996) Long-term treatment of atherosclerotic minipigs with isosorbide dinitrate restores nitric oxide release from endothelial cells, and inhibits vascular smooth muscle cell proliferation. Endothelium 4:235-245
15. Rolland PH, Sampol J, Lacarelle B, Arnoux D, Leca F, Gueydon E, Cano JP (1985) Differential inhibitory effects of isosorbide dinitrate and its mononitrate metabolites on platelet aggregation and thromboxane formation. Pharmacol Res 2:87-90
16. Radomski MW, Palmer RMJ, Moncada S (1987) The anti-aggregating properties of vascular endothelium: Interactions between prostacyclin and nitric oxide. Br J Pharmacol 92:639-646
17. Lablanche JM, Grollier G, Lusson JR, Bassand JP, Drobinski G, Bertrand B, Battaglia S, Desveaux B, Juilliere Y, Juliard JM, Metzger JP, Coste P, Quiret JC, Dubois-Rande JL, Crochet PD, Letac B, Boschat J, Virot P, Finet G, Le B, Livarek B, Leclercq F, Beard T, Giraud T, Bertrand ME, et al. (1997) Effect of the direct nitric oxide donors linsidomine and molsidomine on angiographic restenosis after coronary balloon angioplasty. The ACCORD Study (Angioplastic Coronaire Corvasal Diltiazem). Circulation 95:83-89
18. Fromson JM, Illing HP, Ings RM, Johnson KI, Ostrowski J, Schraven E, Steward A (1981) Absorption and disposition of [14C]molsidomine in laboratory animals. Arzneimittelforschung 31:337-345
19. Charpiot P, Rolland PH, Friggi A, Piquet P, Scalbert E, Bodard H, Barlatier A, Latrille V, Tranier P, Mercier C (1993) ACE inhibition with perindopril and atherogenesis-induced structural and functional changes in minipig arteries. Arterioscler Thromb Vasc Biol 13:1125-1138
20. Jourdheuil-Rahmani D, Rolland PH, Masset D, Garcon D, Rahmani R (1995) Alterations of methionine fluxes and incorporation in intestines of miniature pigs fed a diet high in caseinate are restricted by angiotensin-converting enzyme inhibitor. J Nutr 125:3011-3019
21. Rolland PH, Friggi A, Barlatier A, Piquet P, Latrille V, Faye MM, Guillou J, Charpiot P, Bodard H, Ghiringhelli O (1995) Hyperhomocysteinemia-induced vascular damage in the minipig: Captopril-hydrochlorothiazide combination prevents elastic alterations. Circulation 91:1161-1174
22. Rolland PH, Charifi AB, Verrier C, Bodard H, Friggi A, Piquet P, Moulin G, Bartoli JM (1999) Hemodynamics and wall mechanics after stent placement in swine iliac arteries: Comparative results from six stent designs. Radiology 213:229-246
23. Mekkaoui C, Friggi A, Rolland PH, Bodard H, Piquet P, Bartoli JM, Mesana T (2001) Simultaneous measurements of arterial diameter and blood pressure to determine the arterial compliance, wall mechanics and stresses in vivo. Eur J Vasc Endovasc Surg 21:208-213
24. Rolland PH, Jouve R, Pellegrin E, Mercier C, Serradimigni A (1984) Alteration in prostacyclin and prostaglandin E2 production: Correlation with changes in human aortic atherosclerotic disease. Arterioscler Thromb Vasc Biol 4:70-78
25. Fonseca FAH, Izar MCO, Fuster V, Gallo R, Padurean A, Fallon JT, Schachter EN, Chesebro JB, Badimon JJ (2001) Chronic endothelial dysfunction after oversized coronary balloon angioplasty in pigs: A 12-week follow-up of coronary vasoreactivity in vivo and in vitro. Atherosclerosis 154:61-69
26. Grinstead WC, Rodgers GP, Mazur W, Cromeens DM, French BA, West MS, Raizner AE (1993) Amiprilose in the prevention of restenosis after coronary intervention in a swine. Coron Artery Dis 4:277-281
27. Ignarro LJ, Buga GM, Wei LH, Bauer PM, Wu GY, Del Soldato P. (2001) Role of the arginine-nitric oxide pathway in the regulation of vascular smooth muscle cell proliferation. Proc Natl Acad Sci USA 98:4202-4208
28. Ambrose JA, Almeida OD, Sharma SK, Dangas G, Ratner DE (1997) Angiographic evolution of intracoronary thrombus and dissection following percutaneous transluminal coronary angioplasty (the Thrombolysis and Angioplasty in Unstable Angina [TAUSA] trial). Am J Cardiol 79:559-563
29. Schafer AI, Alexander RW, Handin RI (1980) Inhibition of platelet function by organic nitrate vasodilators. Blood 55:649-654
30. van't Hof AWJ, Liem AL, de Boer MJ, Hoorntje JCA, Suryapranata H, Zijlstra F (1999) A randomized comparison of intra-aortic balloon pumping after primary coronary angioplasty in high risk patients with acute myocardial infarction. Eur Heart J 20:659-665
31. Yusuf S, Macmahon S, Collins R, Peto R (1988) Effect of intravenous nitrates on mortality in acute myocardial infarction: An overview of the randomized trials. Lancet II:1088-1092
32. Glagov S, Weisenberg E, Zarins CK, Stankuvanicus R, Kolettis J (1987) Compensatory enlargement of human atherosclerotic coronary arteries. N Engl J Med 45:1371-1375
33. Post MJ, Desmet BJGL, Vanderhelm Y, Borst C, Kuntz RE (1997) Arterial remodeling after balloon angioplasty or stenting in an atherosclerotic experimental model. Circulation 96:996-1003
34. Greenwald SE, Moore JE, Rachev A, Kane TPC, Meister JJ (1997) Experimental investigation of the distribution of residual strains in the artery wall. J Biomech Eng 119:438-444
35. Moore JE Jr, Xu C, Glagov S, Zarins CK, Ku DN (1994) Fluid wall shear stress measurements in a model of the human abdominal aorta: Oscillatory behavior and relationship to atherosclerosis. Atherosclerosis 110:225-240
36. Wang YX, Halks-Miller M, Vergona R, Sullivan ME, Fitch R, Mallari C, Martin-McNulty B, Da Cunha V, Freay A, Rubanyi GM, Kauser K (2000) Increased aortic stiffness assessed by pulse wave velocity in apolipoprotein E-deficient mice. Am J Physiol 45:H428-H434
37. Creager MA, Selwyn A (1997) When normal cholesterol levels injure the endothelium. Circulation 96:3255-3257
38. Berenger FP, Cano JP, Rolland PH (1987) Antithrombogenic endothelial cell defense: Basal characteristics in cultured endothelial cells and modulation by short-term and long-term exposure to isosorbide nitrates. Circ Res 60:612-620
39. Tsutsui M, Onoue H, Iida Y, Smith L, O'Brien T, Katusic ZS (1999) Adventitia-dependent relaxations of canine basilar arteries transduced with recombinant enos gene. Am J Physiol 45:H1846-H1852
40. Chen AFY, Obrien T, Tsutsui M, Kinoshita H, Pompili VJ, Crotty TB, Spector DJ, Katusic ZS (1997) Expression and function of recombinant endothelial nitric oxide synthase gene in canine basilar artery. Circulation 80:327-335
41. Haberstroh J, Mand U, Lucke I, Breuer H, Ahrens M, Vonspecht BU (1997) Technique of chronic intravascular catheterization for monitoring haemodynamic and laboratory values in conscious swine. Lab Animals 31:70-73
42. Shi Y, Obrien JE, Fard A, Mannion JD, Wang D, Zalewski A (1996) Adventitial myofibroblasts contribute to neointimal formation in injured porcine coronary arteries. Circulation 94:1655-1664
43. Li GH, Chen SJ, Oparil S, Chen YF, Thompson JA (2000) Direct in vivo evidence demonstrating neointimal migration of adventitial fibroblasts after balloon injury of rat carotid arteries. Circulation 101:1362-1365