Synthesis of peptide dendrimers based on a β-cyclodextrin core with guest binding ability

Tetrahedron Letters

Volumn 44, Issue 32, 2003, Pages 6125-6128

  Muhanna, Abdullah M A ^a   Ortiz Salmerón, Emilia ^a   García Fuentes, Luis ^a   Giménez Martínez, Juan J ^a   Vargas Berenguel, Antonio ^a  

^a UNIVERSITY OF ALMERÍA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ADAMANTANE; BETA CYCLODEXTRIN; CARBOXYLIC ACID DERIVATIVE; PEPTIDE; PHENYLALANINE; VALINE;

AMINO ACID COMPOSITION; ARTICLE; BINDING AFFINITY; CALORIMETRY; COMPLEX FORMATION; DRUG SYNTHESIS; PARAMETER; PEPTIDE SYNTHESIS; THERMODYNAMICS; TITRIMETRY;

EID: 0038305145     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(03)01432-1     Document Type: Article

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28. Isothermal titration calorimetry experiments were performed using an MCS isothermal titration calorimeter (ITC) from Microcal, Inc. (Northampton, MA). The calorimeter was calibrated by known heat pulses as recommended by the manufacturer. The observed heat effects were concentration-independent and were identical to the heat signals detected after the saturation is reached. The raw experimental data were presented as the amount of heat produced per second following each injection of guest into the CD derivative solution (corrected for the guest heats of dilution) as a function of time. The amount of heat produced per injection was calculated by integration of the area under individual peaks by the Origin software provided with the instrument. The errors are provided by the software from the best fit of the experimental data to the model of equal and independent sites, and correspond to the standard deviation in the fitting of the curves.