Use of sodium chloride to facilitate reduction of particle size of dexamethasone during ball milling

Drug Development and Industrial Pharmacy

Volumn 29, Issue 3, 2003, Pages 367-373

  Apte, Shireesh P ^a   Cagle, Mike ^a   Bryant, Ronald ^a   Weidenbach, Annita ^a   Kulshreshtha, Alok K ^a  

^a Alcon Research Inc   (United States)

Author keywords

Ball milling; Dexamethasone; Polsorbate 20; Sodium chloride

Indexed keywords

BENZALKONIUM CHLORIDE; DEXAMETHASONE; MANNITOL; POLYSORBATE 20; POLYSORBATE 80; SODIUM CHLORIDE; SURFACTANT; WATER;

ARTICLE; BALL MILLING; DIFFERENTIAL SCANNING CALORIMETRY; DIFFUSION; DRUG BIOAVAILABILITY; DRUG FORMULATION; GRINDING; HYDROPHOBICITY; MELTING POINT; MICELLE; PARTICLE SIZE; PHASE TRANSITION; SURFACE TENSION;

BENZALKONIUM COMPOUNDS; CHEMISTRY, PHARMACEUTICAL; DEXAMETHASONE; DRUG COMPOUNDING; EXCIPIENTS; MANNITOL; PARTICLE SIZE; POLYSORBATES; SODIUM CHLORIDE; SURFACE-ACTIVE AGENTS; SUSPENSIONS;

EID: 0038302758     PISSN: 03639045     EISSN: None     Source Type: Journal    
DOI: 10.1081/DDC-120018211     Document Type: Article

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