Characterization of xanthan gum biosynthesis in a centrifugal, packed-bed reactor using metabolic flux analysis

Process Biochemistry

Volumn 38, Issue 11, 2003, Pages 1617-1625

  Hsu, Chia Hua ^a   Lo, Y Martin ^a  

^a UNIVERSITY OF MARYLAND   (United States)

Author keywords

Bioreactor; Matrix algebra; Metabolic flux analysis; Oxygen transfer; Productivity; Xanthan

Indexed keywords

XANTHOMONAS; XANTHOMONAS CAMPESTRIS;

EID: 0038301902     PISSN: 13595113     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0032-9592(03)00054-2     Document Type: Article

References (55)

1. Meyer EL, Fuller GG, Clark RC, Kulicke WM. Investigation of xanthan gum solution behavior under shear-flow using rheooptical techniques. Macromolecules 1993;26(3):504-11.
2. Podolsak AK, Tiu C, Saeki T, Usui H. Rheological properties and some applications for rhamsan and xanthan gum solutions. Polym Int 1996;40(3):155-67.
3. Sutherland IW, Kennedy L. Polysaccharide lyases from gellan-producing Sphingomonas spp. Microbiology (UK) 1996;142:867-72.
4. Garcia-Ochoa F, Castro EG, Santos VE. Oxygen transfer and uptake rates during xanthan gum production. Enzyme Microb Technol 2000;27(9):680-90.
5. Leela JK, Sharma G. Studies on xanthan production from Xanthomonas campestris. Bioprocess Eng 2000;23(6):687-9.
6. Lo YM, Yang ST, Min DB. Effects of yeast extract and glucose on xanthan production and cell growth in batch culture of Xanthomonas campestris. Appl Microbiol Biotechnol 1997;47(6):689-94.
7. Garcia-Ochoa F, Santos VE, Alcon A. Xanthan gum production - an unstructured kinetic model. Enzyme Microb Technol 1995;17(3):206-17.
8. Garcia-Ochoa F, Santos VE, Alcon A. Simulation of xanthan gum production by a chemically structured kinetic model. Math Comput Simul 1996;42(2-3):187-95.
9. Lo YM, Hsu CH, Yang ST, Min DB. Oxygen transfer characteristics of a centrifugal, packed-bed reactor during viscose xanthan fermentation. Bioprocess Biosyst Eng 2001;24:187-93.
10. Yang ST, Lo YM, Min DB. Xanthan gum fermentation by Xanthomonas campestris immobilized in a novel centrifugal fibrous-bed bioreactor. Biotechnol Prog 1996;12(5):630-7.
11. Yang ST, Lo YM, Chattopadhyay D. Production of cell-free xanthan fermentation broth by cell adsorption on fibers. Biotechnol Prog 1998;14(2):259-64.
12. Whitfield C, Sutherland IW, Cripps RE. Glucose metabolism in Xanthomonas campestris. J Gen Microbiol 1982;128(5):981-5.
13. Letisse F, Chevallereau P, Simon JL, Lindley ND. Kinetic analysis of growth and xanthan gum production with Xanthomonas campestris on sucrose, using sequentially consumed nitrogen sources. Appl Microbiol Biotechnol 2001;55(4):417-22.
14. Jarman TR, Pace GW. Energy requirements for microbial exopolysaccharide synthesis. Arch Microbiol 1984;137(3):231-5.
15. Garcia-Ochoa F, Santos VE, Alcon A. Metabolic structured kinetic model for xanthan production. Enzyme Microb Technol 1998;23(1-2):75-82.
16. Pons A, Dussap CG, Gros JB. Modeling Xanthomonas campestris batch fermentations in a bubble column. Biotechnol Bioeng 1989;33(4):394-405.
17. Becker A, Katzen F, Puhler A, Ielpi L. Xanthan gum biosynthesis and application: a biochemical/genetic perspective. Appl Microbiol Biotechnol 1998;50(2):145-52.
18. Vallino JJ, Stephanopoulos G. Metabolic flux distributions in Corynebacterium glutamicum during growth and lysine over-production. Biotechnol Bioeng 1993;41(6):633-46.
19. Varma A, Palsson BO. Parametric sensitivity of stoichiometric flux balance models applied to wild-type Escherichia coli metabolism. Biotechnol Bioeng 1995;45(1):69-79.
20. Jin S, Ye KM, Shimizu K. Metabolic flux distributions in recombinant Saccharomyces cerevisiae during foreign protein production. J Biotechnol 1997;54(3):161-74.
21. Marx A, Striegel K, de Graaf AA, Sahm H, Eggeling L. Response of the central metabolism of Corynebacterium glutamicum to different flux burdens. Biotechnol Bioeng 1997;56(2):168-80.
22. Hua Q, Yang C, Shimizu K. Metabolic control analysis for lysine synthesis using Corynebacterium glutamicum and experimental verification. J Biosci Bioeng 2000;90(2):184-92.
23. Stephanopoulos GN, Aristidou AA, Nielson J. Metabolic flux analysis. In: Metabolic engineering principle and methodologies, 1st ed. San Diego: Academic Press, 1998:309-51.
24. Shimizu K. An overview on metabolic systems engineering approach and its future perspectives for efficient microbial fermentation. J Chin Inst Chem Eng 2000;31(5):429-42.
25. Klinke S, Dauner M, Scott G, Kessler B, Witholt B. Inactivation of isocitrate lyase leads to increased production of medium chain length poly(3-hydroxyalkanoates) in Pseudomonas putida. Appl Environ Microbiol 2000;66(3):909-13.
26. Christensen J, Christiansen T, Gombert AK, Thykaer J, Nielsen J. Simple and robust method for estimation of the split between the oxidative pentose phosphate pathway and the Embden-Meyerhof-Parnas pathway in microorganisms. Biotechnol Bioeng 2001;74(6):517-23.
27. van Wegen RJ, Lee SY, Middelberg APJ. Metabolic and kinetic analysis of poly(3-hydroxybutyrate) production by recombinant Escherichia coli. Biotechnol Bioeng 2001;74(1):70-80.
28. Lin YH, Bayrock D, Ingledew WM. Metabolic flux variation of Saccharomyces cerevisiae cultivated in a multistage continuous stirred tank reactor fermentation environment. Biotechnol Prog 2001;17(6):1055-60.
29. Pons A, Dussap CG, Pequignot C, Gros JB. Metabolic flux distribution in Corynebacterium melassecola ATCC 17965 for various carbon sources. Biotechnol Bioeng 1996;51(2):177-89.
30. Shi HD, Shiraishi M, Shimizu K. Metabolic flux analysis for biosynthesis of poly(beta-hydroxybutyric acid) in Alcaligenes eutrophus from various carbon sources. J Ferment Bioeng 1997;84(6):579-87.
31. Calik P, Calik G, Takac S, Ozdamar TH. Metabolic flux analysis for serine alkaline protease fermentation by Bacillus licheniformis in a defined medium: effects of the oxygen transfer rate. Biotechnol Bioeng 1999;64(2):151-67.
32. Hua Q, Shimizu K. Effect of dissolved oxygen concentration on the intracellular flux distribution for pyruvate fermentation. J Biotechnol 1999;68(2-3):135-47.
33. Vangulik WM, Heijnen JJ. A metabolic network stoichiometry analysis of microbial growth and product formation. Biotechnol Bioeng 1995;48(6):681-98.
34. Takiguchi N, Shimizu H, Shioya S. An on-line physiological state recognition system for the lysine fermentation process based on a metabolic reaction model. Biotechnol Bioeng 1997;55(1):170-81.
35. Hua Q, Araki M, Koide Y, Shimizu K. Effects of glucose, vitamins, and DO concentrations on pyruvate fermentation using Torulopsis glabrata IFO 0005 with metabolic flux analysis. Biotechnol Prog 2001;17(1):62-8.
36. Nielsen J. Metabolic engineering: techniques for analysis of targets for genetic manipulations. Biotechnol Bioeng 1998;58(2-3):125-32.
37. Nielsen J. The role of metabolic engineering in the production of secondary metabolites. Curr Opin Microbiol 1998;1(3):330-6.
38. Ma HW, Zhao XM, Tang YJ. Analysis of data on xanthan fermentation in stationary phase using black box and metabolic network models. Chin J Chem Eng 1999;7(4):321-5.
39. Amanullah A, Serrano Carreon L, Castro B, Galindo E, Nienow AW. The influence of impeller type in pilot scale xanthan fermentations. Biotechnol Bioeng 1998;57(1):95-108.
40. Shu CH, Yang ST. Effects of temperature on cell growth and xanthan production in batch cultures of Xanthomonas campestris. Biotechnol Bioeng 1990;35(5):454-68.
41. Ielpi L, Couso RO, Dankert MA. Sequential assembly and polymerization of the polyprenol linked pentasaccharide repeating unit of the xanthan polysaccharide in Xanthomonas campestris. J Bacteriol 1993;175(9):2490-500.
42. Bradbury JF, Genus II. Xanthomonas. In: Krieg NR, Holt JG, editors. Bergey's manual of determinative bacteriology, 9th ed. Baltimore, MD: Williams & Wilkins, 1994:199-211.
43. Zupke C, Stephanopoulos G. Intracellular flux analysis in hybridomas using mass balances and in-vitro C-13 NMR. Biotechnol Bioeng 1995;45(4):292-303.
44. Voordouw G, Vandervies SM, Themmen APN. Why are 2 different types of pyridine nucleotide transhydrogenase found in living organisms. Eur J Biochem 1983;131(3):527-33.
45. Sutherland IW. Biosynthesis of microbial exopolysaccharides. Adv Microb Physiol 1982;23:79-150.
46. Davidson IW. Production of polysaccharide by Xanthomonas campestris in continuous culture. FEMS Microbiol Lett 1978;3(6):347-9.
47. Tait MI, Sutherland IW, Clarkesturman AJ. Effect of growth conditions on the production, composition and viscosity of Xanthomonas campestris exopolysaccharide. J Gen Microbiol 1986;132:1483-92.
48. Funahashi H, Yoshida T, Taguchi H. Effect of glucose concentration on xanthan gum production by Xanthomonas campestris. J Ferment Technol 1987;65(5):603-6.
49. Quinlan AV. Kinetics of secondary metabolite synthesis in batch culture when 2 different substrates limit cell growth and metabolite production - xanthan synthesis by Xanthomonas campestris. Ann New York Acad Sci 1986;469:259-69.
50. Flores F, Torres LG, Galindo E. Effect of the dissolved oxygen tension during cultivation of Xanthomonas campestris on the production and quality of xanthan gum. J Biotechnol 1994;34(2):165-73.
51. Herbst H, Schumpe A, Deckwer WD. Xanthan production in stirred tank fermentation: oxygen transfer and scale-up. Chem Eng Technol 1992;15:425-34.
52. Lessie TG, Phibbs PV. Alternative pathways of carbohydrate utilization in Pseudomonads. Annu Rev Microbiol 1984;38:359-87.
53. Banerjee PC, Darzins A, Maitra PK. Gluconeogenic mutations in Pseudomonas aeruginosa - genetic linkage between fructose bisphosphate aldolase and phosphoglycerate kinase. J Gen Microbiol 1987;133:1099-107.
54. Shuler ML, Kargi F. Glucose metabolism: glcolysis and the TCA cycle. In: Bioprocess engineering, 2nd ed. Englewood Cliff, New Jersey: Prentice Hall, 1992.
55. Calik P, Calik G, Ozdamar TH. Oxygen transfer effects in serine alkaline protease fermentation by Bacillus licheniformis: use of citric acid as the carbon source. Enzyme Microb Technol 1998;23(7-8):451-61.