A need for a 'whole-istic functional genomics' approach in complex human diseases: Arthritis

Arthritis Research and Therapy

Volumn 5, Issue 2, 2003, Pages 76-79

  Amin, Ashok R ^a  

^a NYU HOSPITAL FOR JOINT DISEASES   (United States)

Author keywords

Arthritis; Genomics; Inflammation; Proteomics

Indexed keywords

ARTHRITIS; ARTICLE; BIOINFORMATICS; CELL FUNCTION; GENE EXPRESSION SYSTEM; GENE FUNCTION; GENE STRUCTURE; GENE TECHNOLOGY; GENETIC CORRELATION; GENOME ANALYSIS; HAPLOTYPE; HOMEOSTASIS; HUMAN; NONHUMAN; PATHOGENESIS; SINGLE NUCLEOTIDE POLYMORPHISM;

ARTHRITIS; COMPUTATIONAL BIOLOGY; GENOMICS; HUMANS; PROTEOMICS;

EID: 0038300838     PISSN: 14786354     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. McCarty DJ: Differential diagnosis of arthritis: analysis of signs and symptoms. In Arthritis and Allied Conditions: A Textbook of Rheumatology. Edited by Koopman WJ. Philadelphia: Lippincott; 1998:39-50.
2. Aigner T, McKenna L: Molecular pathology and pathobiology of osteoarthritic cartilage. Cell Mol Life Sci 2002, 59:5-18.
3. Attur MG, Dave M, Akamatsu M, Katoh M, Amin AR: Osteoarthritis or osteoarthrosis: the definition of inflammation becomes a semantic issue in the genomic era of molecular medicine. Osteoarthritis Cartilage 2002, 10:1-4.
4. Chong L, Ray LB: Whole-istic biology [abstract]. Science 2002, 295:1661.
5. Attur MG, Dave, MN, Tsunoyama K, Akamatsu M, Kobori M, Miki J, Abramson SB, Katoh M, Amin AR: 'A system biology' approach to bioinformatics and functional genomics in complex human diseases: arthritis. Curr Issues Mol Biol 2002, 4:129-146.
6. Amin AR: Pharmacogenomics: hype, hope, or metamorphosis of molecular medicine and pharmaceuticals. Trends Pharmacol Sci 2002, 23:583.
7. Watanabe N, Ando K, Yoshida S, Inuzuka S, Kobayashi M, Matsui N, Okamoto T: Gene expression profile analysis of rheumatoid synovial fibroblast cultures revealing the overexpression of genes responsible for tumor-like growth of rheumatoid synovium. Biochem Biophys Res Commun 2002, 294:1121-1129.
8. Gu J, Marker-Hermann E, Baeten D, Tsai WC, Gladman D, Xiong M, Deister H, Kuipers JG, Huang F, Song YW, Maksymowych W, Kalsi J, Bannai M, Seta N, Rihl M, Crofford LJ, Veys E, De Keyser F, Yu DT: A 588-gene microarray analysis of the peripheral blood mononuclear cells of spondyloarthropathy patients. Rheumatology 2002, 41:759-766.
9. Aszodi A, Hunziker EB, Olsen BR, Fassler R: The role of collagen II and cartilage fibril-associated molecules in skeletal development. Osteoarthritis Cartilage 2001, 9(suppl A):S150-S159.
10. Clouthier DE, Williams SC, Yanagisawa H, Wieduwilt M, Richardson JA, Yanagisawa M: Signaling pathways crucial for craniofacial development reveal by endothelin-A receptor-deficient mice. Dev Biol 2000, 217:10-24.
11. Miller CT, Schilling TF, Lee K, Parker J, Kimmel CB: Sucker encodes a zebrafish endothelin-1 required for ventral pharyngeal arch development. Development 2000, 127:3815-3828.
12. Mukundan AG, Dave M, Cipolletta C, Kang P, Goldring MB, Patel IR, Abramson SB, Amin AR: Reversal of autocrine and paracrine effects of interleukin 1 (IL-1) in human arthritis by type II IL-1 decoy receptor. J Biol Chem 2000, 275:40307-40315.
13. Bajorath J: Rational drug discovery revisited: interfacing experimental programs with bio- and chemo-informatics. Drug Discov Today 2001, 6:989-995.
14. Lai E: Application of SNP technologies in medicine: lessons learned and future challenges. Genome Res 2001, 11:927-929.
15. Yaspo, ML: Taking a functional genomics approach in molecular medicine. Trends Mol Med 2001, 7:494-501.