Combined efficacies of lipoic acid and meso-2,3-dimercaptosuccinic acid on lead-induced erythrocyte membrane lipid peroxidation and antioxidant status in rats

Human and Experimental Toxicology

Volumn 22, Issue 4, 2003, Pages 183-192

  Sivaprasad, R ^a   Nagaraj, M ^a   Varalakshmi, P ^a  

^a UNIVERSITY OF MADRAS   (India)

Author keywords

Antioxidants; DL lipoic acid; Erythrocytes; Lead acetate; Lipid peroxidation; Meso 2,3 dimercaptosuccinic acid

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATASE (CALCIUM); ADENOSINE TRIPHOSPHATASE (MAGNESIUM); ALANINE AMINOTRANSFERASE; ANTIOXIDANT; ASPARTATE AMINOTRANSFERASE; CATALASE; DRINKING WATER; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HEMOGLOBIN; LEAD ACETATE; MEMBRANE LIPID; POTASSIUM ION; SODIUM ION; SUCCIMER; SUPEROXIDE DISMUTASE; THIOCTIC ACID;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BIOCHEMISTRY; BODY WEIGHT; CELL DAMAGE; CONTROLLED STUDY; DRUG EFFICACY; ENZYME ACTIVITY; ERYTHROCYTE MEMBRANE; EXPOSURE; HEMATOCRIT; LEAD BLOOD LEVEL; LEAD POISONING; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; REVIEW; TOXICOLOGICAL PARAMETERS;

ALANINE TRANSAMINASE; ANIMALS; ANTIDOTES; ANTIOXIDANTS; ASPARTATE AMINOTRANSFERASES; ERYTHROCYTE MEMBRANE; LEAD POISONING; LIPID PEROXIDATION; MALE; MODELS, ANIMAL; OXIDATIVE STRESS; RATS; RATS, WISTAR; SUCCIMER; THIOCTIC ACID;

ANIMALIA; FELIS CATUS;

EID: 0038294601     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1191/0960327103ht335oa     Document Type: Review

References (65)

1. Liou SH. Occupational diseases profile in Taiwan, Republic of China. Ind Health 1994; 32: 107-18.
2. Solliway BM, Schaffer A, Pratt H, Yannai S. Effects of treatment to lead on selected biochemical and haematological variables. Pharmacol Toxicol 1996; 78: 18-22.
3. Gurer H, Ozgunes H, Saygin E, Ercal N. Antioxidant effects of taurine against lead-induced oxidative stress. Arch Environ Contam Toxicol 2001; 41: 397-402.
4. Haeger-Aronsen B, Abdulla M, Fristedt BI. Effect of lead and amino levulinic acid dehydratase activity in red blood cells. Arch Environ Health 1971; 23: 440-45.
5. Spitz DR, Sullivan SJ, Malcom RR, Roberts RJ. Glutathione dependent metabolism and detoxification of 4-hydroxy 2-nonenal. Free Radic Biol Med 1991; 11: 415-23.
6. Simons TJB. Active transport of lead by the calcium pump in human red cell ghosts. J Physiol 1988; 405: 105-13.
7. Leggett RW. An age-specific kinetic model of lead metabolism in humans. Environ Health Perspect 1993; 101: 598-616.
8. Lawton LJ, Donaldson WE. Lead-induced tissue fatty acid alterations and lipid peroxidation. Biol Trace Elem Res 1991; 28: 83-97.
9. Waldron HA. The anemia of lead poisoning: a review. Br J Ind Med 1966, 23: 83-100.
10. Hasan J, Hernberg S, Metsälä P, Vihko V. Enhanced potassium loss in blood cells from men exposed to lead. Arch Environ Health 1967; 14: 309-12.
11. +) ATPase, in lead poisoning. Arch Environ Health 1967; 14: 313-18.
12. Valentino M, Fiorini RM, Curatola G, Governa M. Changes of membrane fluidity in erythrocytes of lead-exposed workers. Int Arch Occup Environ Health 1982; 51: 105-12.
13. Fukumoto K, Karai I, Horiguchi S. Effect of lead on erythrocyte membranes. Br J Ind Med 1983; 40: 220-23.
14. Calderon SJV, Quintanar EMA, Hernandez LCE, Gonzalez MMT. Effect of lead on the calcium transport in human erythrocyte. Hum Exp Toxicol 1999; 18: 146-53.
15. Shafiq-ur-Rehman S, Abdulla M. Impacted lead on phospholipid metabolism in human erythrocyte membranes. Bull J Trace Occup Environ Health 1993; 2: 35.
16. Jansen YMW, Houten BV, Borm PJA, Mossman BT. Biology of disease. Cell and tissue responses to oxidative damages. Lab Invest 1993, 69: 261-74.
17. Packer L, Witt EH, Tritschler HJ. Alpha-lipoic acid as a biological antioxidant. Free Radic Biol Med 1995; 19: 227-50.
18. Kagan V, Khan S, Swanson C, Shvedova A, Serbinova E, Packer L. Antioxidant action of thioctic acid and dihydrolipoic acid. Free Radic Biol Med 1990; 9(suppl): 15.
19. Sumathi R, Kalpana Devi V, Varalakshmi P. DL-α-lipoic acid protection against cadmium induced tissue lipid peroxidation. Med Sci Res 1994; 22: 23-25.
20. Anuradha B, Varalakshmi P. Protective role of DL-α-lipoic acid against mercury-induced neural lipid peroxidation. Pharmacol Res 1999; 39: 67-80.
21. Gurer H, Ozgunes H, Oztezcan S, Ercal N. Antioxidant role of α-lipoic acid in lead toxicity. Free Radic Biol Med 1999; 26: 75-81.
22. Ding Y, Gonick HC, Vaziri ND. Lead promotes hydroxyl radical generation and lipid peroxidation in cultured aortic endothelial cells. Am J Hyper 2000; 13: 552-55.
23. Friedheim E, Corvi C, Walker CJ. Meso-dimercaptosuccinic acid - a chelating agent for the treatment of mercury and lead poisoning. J Pharm Pharmacol 1976; 28: 711-12.
24. Graziano JH, Siris ES, Lolacono N, Silverberg SJ, Turgeon L. 2,3-Dimercaptosuccinic acid as an antidote for lead intoxication. Clin Pharmacol 1983; 37: 431-38.
25. Dodge JT, Mitchell G, Hanahan DT. The preparation and chemical characteristics of haemoglobin-free ghosts of human erythrocytes. Arch Biochem Biophys 1963; 100: 119-30.
26. Quist EH. Regulation of erythrocyte membrane shape by calcium ion. Biochim Biophys Res Commun 1980; 92: 631-37.
27. Beutler E. Red cell metabolism. A manual of biochemical methods, third edition. Orlando, FL: Grune and Stratton, 1984.
28. Drabkin DLR, Austin TH. Spectrophotometric studies, spectrophotometric constants for common haemoglobin derivatives in human, dog and rabbit blood. J Biol Chem 1932; 98: 719-33.
29. Wintrobe MM. Macroscopic examination of the blood. Am J Med Sci 1933; 135: 58.
30. Devasagayam TPA. Lipid peroxidation in rat uterus. Biochim Biophys Acta 1986; 876: 507-14.
31. Bonting SL. Sodium-potassium activated adenosine triphosphatase and cation transport. In Bittar EE ed. Membrane ion transport. England: Wiley Interscience, 1970: 257-363.
32. Ohnishi T, Suzuki T, Ozawas K. A comparative study of plasma membrane magnesium ion ATPase activities in normal, regenerating and malignant cells. Biochim Biophys Acta 1982; 684: 67-74.
33. Hjerten S, Pan H. Purification and characterisation of two forms of a low affinity calcium ion ATPase from erythrocyte membrane. Biochim Biophys Acta 1983; 755: 457-56.
34. Sinha AK. Colorimetric assay of catalase. Anal Biochem 1972; 47: 389-94.
35. Marklund S, Marlund G. Involvement of superoxide anion radical in autooxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem 1974; 47: 469-74.
36. Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hajeman DG, Hoekstra WG. Selenium: biochemical role as a component of glutathione purification and assay. Science 1973; 179: 588-90.
37. Moron MS, Despierre JW, Minnervik B. Levels of glutathione, glutathione reductase and glutathione-S-transferase activities in rat lung and liver. Biochim Biophys Acta 1979; 582: 67-78.
38. King J. The transferases-alanine and aspartate transaminases. In Van D ed. Practical clinical enzymology. London: Norstrand Company Limited, 1965: 121-38.
39. Lowry OH, Rosebrough NJ, Farr AI, Randall RJ. Protein measurement with the Folin-phenol reagent. J Biol Chem 1951; 193: 265-75.
40. Klassen CD. Heavy metals and heavy metal antagonists. In Hardman JG, Limbird LE, Molinoff PB, Ruddon RW, Gilmon AG eds. Goodman and Gilman's Phamacological basis of therapeutics, ninth edition. USA: McGraw-Hill, 1996: 1649-72.
41. Chiu D, Lubin B, Shohet SB. Peroxidative reactions in red cell biology. In Pryor WP ed. Free radicals in biology, volume V. New York: Academic Press, 1982: 115-53.
42. Jendryczko A. Involvement of free radicals in lead poisoning. Med Prev 1998; 49: 1.
43. Terayama K. Effects of lead on electrophoretic mobility, membrane sialic acid, deformability and survival of rat erythrocytes. Ind Health 1993; 31: 113-26.
44. El-Missiry MA. Prophylactic effect of melatonin on lead-induced inhibition of heme biosynthesis and deterioration of antioxidant systems in male rats. J Biochem Mol Toxicol 2000; 14: 57-62.
45. Terayama K, Maehara N, Muratsugu M, Makino M, Yamamura K. Effect of lead on electrophoretic mobility of rat erythrocytes. Toxicology 1986; 40: 259-65.
46. Kalra V, Dua T, Kumar V. Succimer in symptomatic lead poisoning. Ind Pediat 2002; 39: 580-85.
47. Richter ED, Neiman S, Yaffe Y, Gruener N. Lead exposure: effects in Israel. Isr J Med Sci 1980; 16: 89-95.
48. de Silva PE. Determination of lead in plasma and studies on its relationship to lead in erythrocytes. Br J Ind Med 1981; 38: 209-17.
49. Gurer H, Ozgunes H, Neal R, Spitz DR, Ercal N. Antioxidant effects of N-acetylcysteine and succimer in red blood cells from lead-exposed rats. Toxicology 1998; 128: 181-89.
50. Quinlan GJ, Halliwell B, Moorhouse CP and Gutteridge JMC. Action of lead (II) and aluminium (III) ions on iron-stimulated lipid peroxidation in liposomes, erythrocyte and rat liver microsomal fractions. Biochim Biophys Acta 1988; 962: 196-200.
51. Kikugawa K, Kosugi H, Asakura T. Effects of MDA, a product of lipid peroxidation on the function and stability of haemoglobin. Arch Biochem Biophys 1984; 229: 7-14.
52. Rister M, Bachner RL. The alteration of superoxide dismutase, catalase, glutathione peroxidase and NAD(P)H cytochrome-C-reductase in guinea pig polymorphonuclear leukocytes and alveolar macrophages during hypoxia, J Clin Invest 1976; 58: 1174-84.
53. Mylorie AA, Collins H, Umbles C, Kyle J. Erythrocyte superoxide dismutase activity and other parameters of copper status in rats ingesting lead acetate. Toxicol Appl Pharmacol 1986; 82: 512-20.
54. Minami M, Koshi K, Homma K, Suzuki Y. Changes of the activities of superoxide dismutase after exposure to the fume of heavy metals and the significance of zinc in the tissue. Arch Toxicol 1982; 49: 215-25.
55. Pfafferoot C, Meiselman HJ, Hochstein P. The effect of MDA on erythrocyte deformability. Blood 1982; 159: 12-15.
56. Patra RC, Swarup D. Effect of lead on erythrocytic antioxidant defence, lipid peroxide level and thiol groups in calves. Res Vet Sci 2000; 68: 71-74.
57. Svadlenka I, Davidkova E, Rosmus J. Interaction of MDA with collagen. Z Lebensm Unters Forsch 1975; 157: 263-68.
58. Singhal RL, Anderson ME, Meister A, Glutathione, a first line of defense against cadmium toxicity. FASEB J 1987; 1: 220-23.
59. Christie NT, Costa M. In vitro assessment of the toxicity of metal compounds. IV. Disposition of metals in cells: interaction with membranes, glutathione, metallothionein and DNA. Biol Trace Elem Res 1984; 6: 139-58.
60. Korsrud GO, Meldrum JB. Effect of diet on the response in rats to lead acetate given orally or in the drinking water. Biol Trace Elem Res 1988; 17: 167-73.
61. Gurer H, Ercal N. Can antioxidants be beneficial in the treatment of lead poisoning? Free Radic Biol Med 2000; 29: 927-45.
62. + adenosinetriphosphatase. J Toxicol Environ Health 1981; 7: 561-68.
63. 2+)-ATPase activity. Calmodulin involvement. Mol Cell Biochem 1989; 89: 87-93.
64. Tandon SK, Singh S, Prasad S, Mathur M. Influence of L-lysine and zinc administration during exposure to lead or lead and ethanol in rats. Biol Trace Elem Res 1997; 57: 51-58.
65. Sivaprasad R, Nagaraj M, Varalakshmi P. Lipoic acid in combination with a chelator ameliorates lead-induced peroxidative damages in rat kidney. Arch Toxicol 2002; 76: 437-41.