Diosmin pretreatment affects bioavailability of metronidazole

European Journal of Clinical Pharmacology

Volumn 58, Issue 12, 2003, Pages 803-807

  Rajnarayana, K ^a   Reddy, Mada S ^a   Krishna, Devarakonda R ^a  

^a KAKATIYA UNIVERSITY   (India)

Author keywords

CYP3A4; Diosmin; Metronidazole

Indexed keywords

CYTOCHROME P450; DIOSMIN; DRUG METABOLITE; METRONIDAZOLE; VENEX;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG METABOLISM; DRUG URINE LEVEL; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PRIORITY JOURNAL; URINARY EXCRETION;

EID: 0038293257     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00228-002-0543-5     Document Type: Article

References (18)

1. Rajnarayana K, Reddy MS, Chaluvadi MR, Krishna DR (2001) Bioflavonoids classification, pharmacological, biochemical effects and therapeutic potential. Ind J Pharmacol 33:2-16
2. Bouskela E, Donyo KA, Verbeuren TJ (1995) Effects of Daflon 500 mg on increased microvascular permeability in normal hamsters. Int J Microcirc Clin Exp15:22-26
3. Ciolino HP, Wang TT, Yeh GC (1998) Diosmin and diosmetin are agonists of the arylhydrocarbon receptor that differentially affect cytochromeP4501A1 activity. Cancer Res 58:2754-2760
4. Cova D, Angelis DL, Giavarini F, Palladini G, Perego R (1992) Pharmacokinetics and metabolism of oral diosmin in healthy volunteers. Int J Clin Pharmacol Ther Toxicol 30:29-33
5. Perego R, Beccaglia P, Angelini M, Villa P, Cova D (1993) Pharmacokinetic studies of diosmin and diosmetin in perfused rat liver. Xenobiotica 23:1345-1352
6. Edenharder R, Rauscher R, Platt KL (1997) The inhibition by flavonoids of 2-amino-3-methyl imidazo-[4,5-f]-quinoline metabolic activation to a mutagen; a structure activity relationship study. Mutat Res 379:21-32
7. Obermeier MT, White RE, Yong CS (1995) Effect of bioflavonoids on hepaticP450 activities. Xenobiotica 25:575-584
8. Suoping Z, Renke D,Fred KF, Robert EV (1998) Comparative inhibition of human cytochromeP450 1A1 and 1A2 by flavonoids. Drug Metab Dispos 26:989-993
9. Phang JM, Poore CM, Lopaczynska J, Yeh GC (1993) Flavonol stimulated efflux of 7,12-dimethyl benz-(a)-anthracene in multi drug-resistant breast cancer cells. Cancer Res 53:5977-5981
10. Sidelmann UG, Cornett C, Tjournelund J, Hansens H (1996) A comparative study of precision cut liver slices, hepatocytes, and liver microsomes from the Wistar rats using metronidazole as a model substrate. Xenobiotica 26:709-722
11. Pendland SI, Piscitelli SC, Schrecken berger PC, Danzier LH (1994) In vitro activities of metronidazole and its hydroxy metabolite against Bacteroides Spp Antimicrob Agents Chemother 38:2106-2110
12. Galmier MJ, Frasey AM, Bastide M (1998) Simple and sensitive method for determination of metronidazole in human serum by high-performance liquid chromatography. J Chromatogr B 720:239-243
13. Bear WL, Teel RW (2000) Effect of citrus phytochemicals on liver and lung cytochrome P450 activity and on the in vitro metabolism of the tobacco specific nitrosamine NNK. Anticancer Res 20:3323-3329
14. Teel RW, Huynh H (1998) Modulation by phytochemicals of cytochrome P450-linked enzyme activity. Cancer Lett 133:135-141
15. Villa P, Cova D, De FL (1992) Protective effect of diosmin on in vitro cell membrane damage and oxidative stress in cultured rat hepatocytes. Toxicology 73:179-189
16. Reddy MS, Rajnarayana K, Chaluvadi MR, Krishna DR (2001) Bioflavonoids - their pharmacokinetics and interaction with cytochrome P450 isozymes and P-glycoprotein. Ind J Pharm Sci 63:187-195
17. Spina E, Fisani F, Perucca E (1996) Clinically significant pharmacokinetic drug interactions with carbamazepine. An update. Clin Pharmacokinet 31:198-214
18. Levy RH (1995) CytochromeP450 isozymes and antiepileptic drug interactions. Epilepsia 720:8-13