Screening of lovastatin production by filamentous fungi

Iranian Biomedical Journal

Volumn 7, Issue 1, 2003, Pages 29-33

  Samiee, Siamak M ^a   Moazami, Nasrin ^a   Haghighi, Saeid ^b   Mohseni, Farzaneh Aziz ^a   Mirdamadi, Saeid ^a   Bakhtiari, Mohammad Reza ^a  

^a Iranian Research Organisation for Science and Technology   (Iran)

^b PASTEUR INSTITUTE OF IRAN   (Iran)

Author keywords

Aspergillus terreus; Fungal strains; Lovastatin; Screening

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; MEVINOLIN;

ANTIBIOTIC BIOSYNTHESIS; ARTICLE; ASPERGILLUS TERREUS; CHOLESTEROL SYNTHESIS; COMPETITIVE INHIBITION; FUNGAL STRAIN; FUNGUS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SCREENING; THIN LAYER CHROMATOGRAPHY;

ASPERGILLUS; ASPERGILLUS TERREUS; FUNGI;

EID: 0038284127     PISSN: 1028852X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (6)

1. Endo, A. (1979) Monacolin K, a new hypo-cholesterolemic agent that specifically inhibits 3-hydroxy-3-methylglutaryl coenzyme A redu-ctase. J. Antibiot. (Japan) 33: 334-336.
2. Alberts, A.W., Chen, J., Curon, G., Hunt, V., Huff, J., Hoffman, C., Rothrock, J., Lopez, M., Joshau, H., Harris, E., Patchett, A., Monaghan, R., Currie, S., Stapley, E., Albers-Schonberg, G., Hensen, O., Hirshfield, J., Hoogsteen, K., Liesch, J., and Springer, J. (1980) Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutarylcoenzyme A reductase and cholesterol-lowering agent. Proc. Natl. Acad. Sci. USA 77: 3957-3961.
3. Gunde-Cimerman, N., Friedrich, J., Cimerman, A. and Benicki, N., (1973) Screening fungi for the production of an inhibitor of HMG CoA reductase: Production of mevinolin by the fungi of the genus Pleurotus. FEMS Microbiol. Lett. 111: 203-206.
4. Shindia, A.A. (1997) Mevinolin production by some fungi. Folia Microbiol. 42: 477-480.
5. Friedrich, J., Zuzek, M., Bencina, M., Cimerman, A., Strancar, A. and Radez, I. (1995) High-performance liquid chromatographic analysis of mevinolin as mevinolinic acid in fermentation broths. J. Chromatogr. 704: 363-367.
6. Kysilka, R. and Kren, V. (1993) Determination of Lovastatin (mevinolin) and mevinolinic acid in fermentation liquids. J. Chromatogr. 630: 415-417.