Once-a-day controlled-release dosage form of divalproex sodium I: Formulation design and in vitro/in vivo investigations

Journal of Pharmaceutical Sciences

Volumn 92, Issue 6, 2003, Pages 1166-1173

  Qiu, Yihong ^a   Cheskin, Howard S ^a   Engh, Kevin R ^a   Poska, Richard P ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Controlled release; Divalproex sodium; In vitro release; In vitro in vivo relationship; In vivo absorption; Matrix system

Indexed keywords

ALGINIC ACID; FILLER; HYDROXYPROPYLMETHYLCELLULOSE; LUBRICATING AGENT; POLYMER; VALPROATE SEMISODIUM;

ANIMAL EXPERIMENT; ARTICLE; BIPOLAR DISORDER; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOG; DOSE CALCULATION; DRUG ABSORPTION; DRUG DESIGN; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; ENTERIC COATED TABLET; EPILEPSY; HUMAN; HUMAN EXPERIMENT; HYDROPHILICITY; IN VITRO STUDY; IN VIVO STUDY; MANIA; MIGRAINE; NONHUMAN; RANDOMIZED CONTROLLED TRIAL; TABLET;

EID: 0038283006     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.10385     Document Type: Article

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