Selectivity of substance identification by HPLC-DAD in toxicological analysis using a UV spectra library of 2682 compounds

Journal of Analytical Toxicology

Volumn 27, Issue 4, 2003, Pages 233-242

  Herzler, Matthias ^a   Herre, Sieglinde ^a   Pragst, Fritz ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALOID; ILLICIT DRUG; PHENOL DERIVATIVE; POLYCHLORINATED BIPHENYL; POLYCYCLIC AROMATIC HYDROCARBON; REAGENT;

ACIDITY; ARTICLE; CALCULATION; CHEMICAL STRUCTURE; CHROMATOPHORE; DATA BASE; DIODE; DIODE ARRAY DETECTION; DRUG INTOXICATION; ERROR; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INTOXICATION; RELIABILITY; STRUCTURE ANALYSIS; TOXICOLOGY; ULTRAVIOLET SPECTROSCOPY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DATABASES, FACTUAL; DRUG TOXICITY; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; PHARMACEUTICAL PREPARATIONS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 0038281248     PISSN: 01464760     EISSN: None     Source Type: Journal    
DOI: 10.1093/jat/27.4.233     Document Type: Article

References (31)

1. R.A. de Zeeuw. Drug screening in biological fluids. The need for a systematic approach. J. Chromatogr. B: Biomed. Sci. Appl. 689: 71-79 (1997).
2. A. Polettini. Systematic toxicological analysis of drugs and poisons in biosamples by hyphenated chromatographic and spectroscopic techniques. J. Chromatogr. B: Biomed. Sci. Appl. 733: 4763 (1999).
3. F. Pragst, H.H. Maurer, J. Hallbach, U. Staerk, W.R. Külpmann, F. Degel, and H.J. Gibitz. Suchverfahren (General unknown). In Klinisch-toxikologische Analytik, Verfahren und Interpretation, W.R. Külpmann, Ed. Wiley-VCH, Weinheim, Germany, 2002, pp 49-95.
4. K. Pfleger, H.H. Maurer, and A. Weber. Mass Spectral and GC Data of Drugs, Poisons, Pesticides, Pollutants and Their Metabolites, 2nd ed., 1992-2000. Wiley-VCH, Weinheim, Germany, 2000.
5. B. Aebi and W. Bernhard. Advances in the use of mass spectral libraries for forensic toxicology. J. Anal. Toxicol. 26: 149-156 (2002).
6. A. Polettini, A. Groppi, C. Vignali, and M. Montagna. Fully-automated systematic toxicological analysis of drugs, poisons, and metabolites in whole blood, urine, and plasma by gas chromatography-full scan mass spectrometry. J. Chromatogr. B: Biomed. Sci. Appl. 713: 265-279 (1998).
7. P. Marquet. Is LC-MS suitable for a comprehensive screening of drugs and poisons in clinical toxicology? Ther. Drug Monit. 24: 125-133 (2002).
8. W. Weinmann, A. Wiedemann, B. Eppinger, M. Renz, and M. Svoboda. Screening for drugs in serum by electrospray ionization/collision-induced dissociation and library searching. J. Am. Soc. Mass Spec. 10: 1028-1037 (1999).
9. H.H. Maurer. Liquid chromatography-mass spectrometry in forensic and clinical toxicology. J. Chromatogr. B: Biomed. Sci. Appl. 713: 3-25 (1998).
10. M. Rittner, F. Pragst, W.R. Bork, and J. Neumann. Screening method for seventy psychoactive drugs or drug metabolites in serum based on high-performance liquid chromatography-electrospray ionization mass spectrometry. J. Anal. Toxicol. 25: 115-124 (2001).
11. M. Bogusz and M. Wu. Standardized HPLC/DAD system, based on retention indices and spectral library, applicable for systematic toxicological screening. J. Anal. Toxicol. 15: 188-197 (1991).
12. M. Bogusz and M. Erkens. Reversed-phase high-performance liquid chromatographic database of retention indices and UV spectra of toxicologically relevant substances and its interlaboratory use. J. Chromatogr. A 674: 97-126 (1994).
13. S.P. Elliott and K.A. Hale. Applications of an HPLC-DAD drugscreening system based on retention indices and UV spectra. J. Anal. Toxicol. 22: 279-289 (1998).
14. Y. Gaillard and G. Popin. Use of high-performance liquid chromatography with photodiode-array UV detection for the creation of a 600-compound library. Application to forensic toxicology. J. Chromatogr. A 763: 149-163 (1997).
15. E.M. Koves. Use of high-performance liquid chromatographydiode array detection in forensic toxicology. J. Chromatogr. A 692: 103-119 (1995).
16. C.-K. Lai, T. Lee, K.-M. Au, and A.Y.W. Chan. Uniform solid-phase extraction procedure for toxicological drug screening in serum and urine by HPLC with photodiode-array detection. Clin. Chem. 43: 312-325 (1997).
17. W.E. Lambert, E. Meyer, Y. Xue-Ping, and A.P. De Leenheer. Screening, identification, and quantitation of benzodiazepines in postmortem samples by HPLC with photodiode array detection. J. Anal. Toxicol. 19: 35-40 (1995).
18. B.K. Logan, D.T. Stafford, I.R. Tebbett, and C.M. Moore. Rapid screening for 100 basic drugs and metabolites in urine using cation exchange solid-phase extraction and high-performance liquid chromatography with diode array detection. J. Anal. Toxicol. 14: 154-159 (1990).
19. R.D. Maier and M. Bogusz. Identification power of a standardized HPLC-DAD system for systematic toxicological analysis. J. Anal. Toxicol. 19: 79-83 (1995).
20. A. Tracqui, P. Kintz, and P. Mangin. Systematic toxicological analysis using HPLC/DAD. J. Forensic Sci. 40: 254-262 (1995).
21. A. Turcant, A. Premel-Cabic, A. Cailleux, and P. Allain. Toxicological screening of drugs by microbore high-performance liquid chromatography with photodiode-array detection and ultraviolet spectral library searches. Clin. Chem. 37: 1210-1215 (1991).
22. D.W. Hill and A.J. Kind. Reversed-phase solvent-gradient HPLC retention indexes of drugs. J. Anal. Toxicol. 18: 233-242 (1994).
23. F. Pragst, M. Herzler, S. Herre, B.-T. Erxleben, and M. Rothe. UV Spectra of Toxic Compounds. Verlag Dr. Dieter Helm, Heppenheim, Germany, 2001.
24. M. Herzler, F. Pragst, S. Herre, and M. Rothe. Selectivity of photodiode array UV spectra for substance identification in systematic toxicological analysis. In Proceedings of the 37th TIAFT Triennial Meeting, T. Lech, Ed. Institute of Forensic Research Publishers, Krakow, Poland, 2000, pp 122-129.
25. F. Pragst, M. Herzler, and S. Herre. Use of high performance liquid chromatography with photodiode array detection (HPLC-DAD) in clinical toxicology. Klin. Biochem. Metab. 1:13-16 (2000).
26. A.C. Moffat, K.W. Smalldon, and C. Brown. Optimum use of paper, thin-layer and gas-liquid chromatography for the identification of basic drugs I. Determination of effectiveness for a series of chromatographic systems. J. Chromatogr. 90: 1-7 (1974).
27. P.G. Schepers, J.P. Franke, and R.A. de Zeeuw. System evaluation and substance identification in systematic toxicological analysis by the mean list length approach. J. Anal. Toxicol. 7: 272-278 (1983).
28. M. Herzler. Untersuchungen zur Selektivität der HPLC-DAD in der Systematischen Toxikologischen Analyse. Dissertation for the Postgraduate Study Course in Toxicology. University of Leipzig, Leipzig, Germany, 2001.
29. L. Huber and S.A. George, Eds. Diode Array Detection in HPLC. Marcel Dekker, Inc., New York, NY, 1993.
30. U. Demme, B. Ahrens, A. Klein, and R. Werner. Discriminating power nearly one - ion-trap GC-MS as an ideal tool for STA. In: Proceedings of the 38th Meeting of TIAFT, I. Rasanen, Ed. Tallina Raamatutrükikoja OÜ Helsinki, Finland, 2001, 19-26.
31. R.A. de Zeeuw, J. Hartstra, and J.P. Franke. Potential and pitfalls of chromatographic techniques and detection modes in substance identification for systematic toxicological analysis. J. Chromatogr. A 674: 3-13 (1994).