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Volumn 300, Issue 5627, 2003, Pages 1953-1957

Reversal and stabilization of synaptic modifications in a developing visual system

Author keywords

[No Author keywords available]

Indexed keywords

ORGANIC COMPOUNDS; STABILIZATION; VISUAL COMMUNICATION;

EID: 0038275938     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1082212     Document Type: Article
Times cited : (138)

References (33)
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    • 12444324284 scopus 로고    scopus 로고
    • note
    • 2, and 0.005 mM glycine (pH 7.4). For recording, the skin was removed and the brain was split open along the midline to expose the inner surface of the tectum. A low dose of α-bungarotoxin (1 μg/ml) was applied to the bath to prevent muscle contraction. As previously shown (12), this toxin treatment did not significantly affect the retinotectal responses.
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    • 12444330060 scopus 로고    scopus 로고
    • note
    • Materials and methods are available as supporting material on Science Online.
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    • 12444345627 scopus 로고    scopus 로고
    • note
    • The reversal of LTP is not due to a decline in the quality of the recording, because LTP of a similar magnitude can be induced after the reversal (n = 4 cells) (Fig. 4B).
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    • 12444290260 scopus 로고    scopus 로고
    • note
    • For TBS, inputs were stimulated for 20 bursts at 5 Hz, with each burst containing 5 pulses at 200 Hz.
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    • 12444307971 scopus 로고    scopus 로고
    • note
    • Whether an RGC input underwent potentiation or depression after moving-bar stimulation did not depend on the initial strength of that input. Both potentiation and depression were frequently observed at two independent RGC inputs onto the same tectal neuron after moving-bar training.
  • 22
    • 12444318329 scopus 로고    scopus 로고
    • note
    • D-APV infusion in this tectum preparation effectively abolished the NMDA receptor component of EPSCs at the retinotectal synapses, without significantly affecting synaptic currents and spiking activity induced by light exposure (12, 13).
  • 33
    • 12444343832 scopus 로고    scopus 로고
    • note
    • Supported by grants from NSF (grant no. IBN-0196100) and NIH (grant no. NS 36999) (M.-m.P.) and by a National Research Service Award (Q.Z.).


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.