Cellular and molecular mechanisms of collecting duct sodium pump activation in experimental nephrotic syndrome;Mécanismes cellulaires et moléculaires d'activation de la pompe à sodium dans les modèles expérimentaux de syndrome néphrotique

Nephrologie

Volumn 24, Issue 3, 2003, Pages 121-126

  Deschênes, Georges ^a   Feraille, E ^b   Doucet, A ^c  

^a ARMAND TROUSSEAU HOSPITAL   (France)

^b Fondation pour Recherches Medicales   (France)

^c CEA SACLAY   (France)

Author keywords

Cortical collecting duct; Edema; PAN nephrosis; Sodium potassium adenosine triphosphatase

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ADENOSINE TRIPHOSPHATE; AMILORIDE; MESSENGER RNA; POTASSIUM ION; SODIUM ION;

ARTICLE; ASCITES; CONTROLLED STUDY; EXPERIMENTAL MODEL; EXTRACELLULAR SPACE; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; HUMAN; KIDNEY COLLECTING TUBULE; NEPHROTIC SYNDROME; SODIUM ABSORPTION; SODIUM BALANCE; SODIUM INTAKE; SODIUM URINE LEVEL; URINARY EXCRETION;

ANIMALS; CREATININE; ION PUMPS; KIDNEY TUBULES; LINEAR MODELS; NEPHROTIC SYNDROME; PUROMYCIN AMINONUCLEOSIDE; RATS; SODIUM;

EID: 0038247754     PISSN: 02504960     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Cameron J. The nephrotic syndrome: Management, complications and physiopathology. In: Davison A, Cameron J, Grünfeld J, Kerr D, Ritz E, Wiinearls C (eds) Oxford Textbook of Nephrology, Vol 1. Oxford: Oxford Medical Publications, 1998; 461-92.
2. Koomans HA, Braam B, Geers AB, Roos JC, Dorhout Mees EJ. The importance of plasma protein for blood volume and blood pressure homeostasis. Kidney Int 1986; 30: 730-5.
3. Geers AB, Koomans HA, Boer P, Dorhout Mees EJ. Plasma and blood volumes in patients with the nephrotic syndrome. Nephron 1984; 38: 170-3.
4. Firth JD, Raine AE, Ledingham JG. Abnormal sodium handling occurs in the isolated perfused kidney of the nephrotic rat. Clin Sci (Lond) 1989; 76: 387-95.
5. Ichikawa I, Rennke HG, Hoyer JR, Badr KF, Schor N, Troy JL, Lechene CP, Brenner BM. Role for intrarenal mechanisms in the impaired salt excretion of experimental nephrotic syndrome. J Clin Invest 1983; 71: 91-103.
6. Morel F, Doucet A. Functional segmentation of the nephron. In: Seldin D, Giebisch G (eds), The Kidney: Physiology and Pathophysiology. New York: Raven Press Ltd, 1992; 1049-86.
7. Feraille E, Vogt B, Rousselot M, Barlet-Bas C, Cheval L, Doucet A, Favre H. Mechanism of enhanced Na-K-ATPase activity in cortical collecting duct from rats with nephrotic syndrome. J Clin Invest 1993; 91: 1295-300.
8. Vogt B, Favre H. Na+, K(+)-ATPase activity and hormones in single nephron segments from nephrotic rats. Clin Sci (Colch) 1991; 80: 599-604.
9. Grausz H, Lieberman R, Earley LE. Effect of plasma albumin on sodium reabsorption in patients with nephrotic syndrome. Kidney Int 1972; 1: 47-54.
10. Deschênes G, Wittner M, Stefano A, Jounier S, Doucet A. Collecting duct is a site of sodium retention in PAN nephrosis: A rationale for amiloride therapy. J Am Soc Nephrol 2001; 12: 598-601.
11. Deschênes G, Gonin S, Zolty E, Cheval L, Rousselot M, Martin P, Verbavatz J, Feraille E, Doucet A. Increased synthesis and AVP unresponsiveness of Na, K-ATPase in collecting duct from nephrotic rats. J Am Soc Nephrol 2001; 12: 2241-52.
12. Feraille E, Doucet A. Sodium-potassium-adenosinetriphosphatase-dependent sodium transport in the kidney: Hormonal control. Physiol Rev 2001; 81:345-418.
13. Gonin S, Deschênes G, Roger F, Bens M, Martin PY, Carpentier JL, Vandewalle A, Doucet A, Feraille E. Cyclic AMP increases cell surface expression of functional Na,K-ATPase units in mammalian cortical collecting duct principal cells. Mol Biol Cell 2001; 12: 255-64.
14. Deschênes G, Doucet A. Collecting duct (Na+/K+)-ATPase activity is correlated with urinary sodium excretion in rat nephrotic syndromes. J Am Soc Nephrol 2000; 11: 604-15.
15. Perico N, Delaini F, Lupini C, Benigni A, Galbusera M, Boccardo P, Remuzzi G. Blunted excretory response to atrial natriuretic peptide in experimental nephrosis. Kidney Int 1989; 36: 57-64.
16. Valentin JP, Ying WZ, Couser WG, Humphreys MH. Extrarenal resistance to atrial natriuretic peptide in rats with experimental nephrotic syndrome. Am J Physiol 1998; 274: F556-F63.