Inhibition of purified human kidney Na+,K+-ATPase by cyclosporine A: A possible mechanism for drug human nephrotoxicity

Annals of the New York Academy of Sciences

Volumn 986, Issue , 2003, Pages 633-635

  Younes Ibrahim, M ^a   Barnese, M ^a   Burth, P ^b   Castro Faria, M V ^a  

^a STATE UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b FLUMINENSE FEDERAL UNIVERSITY   (Brazil)

Author keywords

Cyclosporine A; Na,K ATPase; Nephrotoxicity

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); CYCLOSPORIN A; KIDNEY ENZYME;

ANIMAL TISSUE; CONFERENCE PAPER; DRUG EFFECT; DRUG MECHANISM; DRUG RESPONSE; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME PURIFICATION; NEPHROTOXICITY; NONHUMAN; RAT; TOXICITY;

ANIMALIA;

EID: 0038239709     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2003.tb07270.x     Document Type: Conference Paper

References (5)

1. KAHAN, B.D. 1989. Drug therapy. Cyclosporine. N. Engl. J. Med. 321: 1725-1738.
2. TUMLIN, J.A. & J.M. SANDS. 1993. Nephron segment-specific inhibition of Na-K-ATPase activity by cyclosporin A. Kidney Int. 43: 246-251.
3. IHARA, H., S. HOSOKAWA, T. OGINO, et al. 1990. Activation of K+ channel and inhibition of Na-K-ATPase of human erythrocytes by cyclosporine; possible role in hiperpotassemia in kidney transplant recipients. Transplant. Proc. 22 (suppl. 4): 1736-1739.
4. +)-ATPase. III. Purification from the outer medulla of mammalian kidney after selective removal of membrane components by sodium dodecylsulphate. Biochim. Biophys. Acta 356: 36-52.
5. +-ATPase inhibitor found in an endotoxin of leptospira. Infect. Immun. 65: 2557-2560.