Expression and role of inducible nitric oxide synthase in ischemia-reperfusion liver in rats

Hepatobiliary and Pancreatic Diseases International

Volumn 2, Issue 2, 2003, Pages 252-258

  Wang, Li Ming ^a   Tian, Xiao Feng ^a   Song, Qian Ying ^a   Gao, Zhen Ming ^a   Luo, Fu Wen ^a   Yang, Chun Ming ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

Inducible nitric oxide synthase; Ischemia reperfusion injury; Liver

Indexed keywords

ALANINE AMINOTRANSFERASE; AMINOETHYLISOTHIOURONIUM; ASPARTATE AMINOTRANSFERASE; MESSENGER RNA; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG EFFECT; LIVER DYSFUNCTION; LIVER ISCHEMIA; LIVER PROTECTION; MALE; NONHUMAN; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RAT; RAT STRAIN; REPERFUSION; REPERFUSION INJURY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING;

ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; LIVER DISEASES; MALE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; RATS; RATS, WISTAR; REPERFUSION INJURY; RNA, MESSENGER; THIOUREA;

EID: 0038205499     PISSN: 14993872     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Lichtman S, Lemasters JJ. Role of cytokines and cytokine-producing cells in reperfusion injury to the liver. Semin Liver Dis 1999;19:171-187.
2. Marubayashi S, Asahara T, Dohi K. Ischemia-reperfusion injury of liver and therapeutic intervention. Hepato Res 2000;16:233-253.
3. Horie Y, Wolf R, Granger DE. Role of nitric oxide in gut ischemic-reperfusion-induced hepatic microvascular dysfunction. Am J Physiol 1997;273:G1003-G1013.
4. Koeppel TA, Thies JC, Schemmer P, et al. Inhibition of nitric oxide synthesis in ischemia/reperfusion of the rat liver is followed by impairment of hepatic microvascular blood flow. J Hepatol 1997;27:163-169.
5. Kurose I, Wolf R, Grisham NB, et al. Modulation of ischemia/reperfusion-induced microvascular dysfunction by nitric oxide. Circ Res 1994;74:376-382.
6. Lu YT, Liu SF, Mitchell JA, et al. The role of endogenous nitric oxide in modulating ischemic-reperfusion injury in the isolated, blood-perfused rat lung. Am J Resp Crit Care 1998;157:273-279.
7. Tong T. MA, Ischiropoulos H, Brass CA. Endotoxin-stimulated nitric oxide production increase injury and reduces rat liver chemiluminescence. Gastroenterology 1995;108:463-469.
8. Thiemermann C, Ruetten H, Wu CC, et al. The multiple organ dysfunction syndrome caused by endotoxin in the rat: attenuation of liver dysfunction by inhibitors of nitric oxide. Br J Pharmacol 1995;116:2845-2851.
9. Liu P, Yin K, Nagele R, et al. Inhibition of nitric oxide synthase attenuates peroxynitrite generation, but augments neutrophil accummulation in hepatic ischemia-reperfusion in rats. J Pharmacol Exp Therap 1998; 284:1139-1146.
10. Isobe M, Katsuramaki T, Hirata K, et al. Beneficial effects of inducible nitric oxide synthase inhibitor on reperfusion injury in the pig liver. Transplantation 1999;68:803-813.
11. Li J, Billiar TR. Nitric oxide. Determinations of nitric oxide production and toxicity in liver. Am J Physiol 1999;276:G1069-G1073.
12. Kuo PC, Alfrey EJ, Abe KY, et al. Cellular localization and effect of nitric oxide synthesis in a rat model of orthotopic liver transplantation. Transplantation 1996;61:305-312.
13. Salkowski CA, Detore G, Mcnally R, et al. Regulation of nitric oxide synthase messenger RNA expression and nitric oxide production by lipopolysaccharide in vivo. J Immunol 1997;158:905-912.
14. Geller DA, Nussler AK, Silvio MD, et al. Cytokines, endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes. Cell Biology 1993;90:522-526.
15. Nagasaki A, Gotoh T, Takeya M, et al. Coinduction of nitric oxide synthase, argininosuccinate synthetase, and argininosuccinate lyase in lipopolysaccharide-treated rats. J Biol Chem 1996;271:2658-2662.
16. Southan G, Zingarelli B, O'Connor M, et al. Spontaneous rearrangement of aminoalkylisothioureas into mercaptoalkylguanidines, a novel class of nitric oxide synthase inhibitors with selectivity towards the inducible isoform. Br J Pharmacol 1996;117:619-932.
17. Southan G, Szabo C, Thiemermann C. Isothioureas: potent inhibitors of nitric oxide synthases with variable isoform selectivity. Br J Pharmacol 1995;114:510-516.
18. Kawano K, Kim YI, Kaketani K, et al. The beneficial effect of cyclosporine on liver ischmia in rats. Transplantation 1989;48:759-764.
19. Lee VG, Johnson ML, Baust J, et al. The roles of iNOS in liver ischemia-reperfusion injury. Shock 2001; 16:355-360.
20. Saetre T, Gundersen Y, Thiemermann C, et al. Aminoethyl- isothiourea, a selective inhibitor of inducible nitric oxide synthase activity, improves liver circulation and oxygen metabolism in a porcine model of endotoxemia. Shock 1998;9:109-115.
21. Chomczynski P. A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples. Biotechniques 1993;15:532-534.
22. Morrissey JJ, Mccracken R, Kaneto H, et al. Location of an inducible nitric oxide synthase mRNA in the normal kidney. Kidney Int 1994;45:998-1005.
23. Gunning P, Ponte P, Okayama H, et al. Isolation and characterization of full-length cDNA clones for human alpha-beta, and gamma-actin mRNAs: akeletal but not cytoplasmic actins have an amino-terminal cysteine that is subsequently removed. Mol Cell Biol 1983;3:787-795.
24. Taylor BS, Alarcon LH, Billiar TR. Inducible nitric oxide synthase in the liver: regulation and function. Biochemistry (moscow) 1998;73:905-923.
25. Vos TA, Gouw ASH, Klok PA, et al. Differential effects of nitric oxide synthase inhibitor on endotoxin-induced liver damage in rats. Gastroenterology 1997; 113:1323-1333.
26. Liu P, Yin K, Yue G, et al. Role of nitric oxide in hepatic ischemia-reperfusion with endotoxemia. J Inflamm 1996;46:144-154.
27. Punzalan C, Cai C, Schroeder R, et al. Redox regulation of the rat hepatocyte iNOS promoter. Surgery 1999;126:450-455.
28. Hur GM, Ryu YS, Yun HY, et al. Hepatic ischemic/ reperfusion in rats induces iNOS gene transcription by activation of NF-κB. Biochem Biophys Res Commun 1999;261:917-922.
29. Peer G, Blum M, Iaina A. Nitric oxide and acute renal failure. Nephron 1996;73:375-381.