Three new alleles of IGHG2 and their prevalence in Danish Caucasians, Mozambican Blacks and Japanese

Tissue Antigens

Volumn 61, Issue 3, 2003, Pages 231-239

  Hougs, Lotte ^a,b   Garred, P ^a   Kawasaki, T ^c   Kawasaki, N ^c   Svejgaard, A ^a   Barington, T ^a,d  

^a Rigshospitalet   (Denmark)

^b STATENS SERUM INSTITUT   (Denmark)

^c KYOTO UNIVERSITY   (Japan)

^d ODENSE UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Allotype; Constant region gene; Human; IgG2; IGHG2

Indexed keywords

ANTIGEN; ASPARAGINE; GENE PRODUCT; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2; IMMUNOGLOBULIN G3; IMMUNOGLOBULIN G4; LEUCINE; PHENYLALANINE; POLYSACCHARIDE; PROTEIN IGHG2; SERINE; UNCLASSIFIED DRUG;

ALLELE; ALLOTYPE; ANTIBODY RESPONSE; ARTICLE; CONTROLLED STUDY; ETHNIC DIFFERENCE; GENE CONVERSION; GENE FREQUENCY; GENE LOCUS; GENE SEQUENCE; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; NORMAL HUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; POPULATION GENETICS; PRIORITY JOURNAL; PROMOTER REGION; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY;

ALLELES; AMINO ACID SEQUENCE; BASE SEQUENCE; DENMARK; GENE FREQUENCY; HUMANS; IMMUNOGLOBULIN G; JAPAN; LINKAGE DISEQUILIBRIUM; MOLECULAR SEQUENCE DATA; MOZAMBIQUE; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL;

EID: 0038193485     PISSN: 00012815     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-0039.2003.00048.x     Document Type: Article

References (31)

1. Kunkel HG, Yount WJ, Litwin SD. Genetically determined antigen of the Ne subgroup of gamma-globulin: Detection by precipitin analysis. Science 1966: 154: 1041-3.
2. Jefferis R, Reimer CB, Skvaril F et al. Evaluation of monoclonal antibodies having specificity for human IgG sub-classes: Results of an IUIS/WHO collaborative study. Immunol Lett 1985: 10: 223-52.
3. Natvig JB, Turner MW. Localization of Gm markers to different molecular regions of the Fc fragment. Clin Exp Immunol 1971: 8: 685-700.
4. Lefranc MP, Giudicelli V, Ginestoux C et al. IMGT, the international ImMunoGeneTics database. Nucl Acids Res 2001: 29: 207-9.
5. Kabat EA, Wu TT, Perry HM, Gottesman KS, Foeller C. Sequences of Proteins of Immunological Interest, 5th edn. Bethesda: U.S. Department Health and Human Services, 1991.
6. Brusco A, de Lange GG, Boccazzi C, Carbonara AO. Molecular characterization of Gm (n+) and G2m (n-) allotypes. Immunogenetics 1995: 42: 414-7.
7. de Lange GG. Polymorphisms of human immunoglobulins. Gm, Am, Em and Km allotypes. Exp Clin Immunogenet 1989: 6: 7-17.
8. Morell A, Skvaril F, Steinberg AG, van Loghem E, Terry WD. Correlations between the concentrations of the four sub-classes of IgG and Gm Allotypes in normal human sera. J Immunol 1972: 108: 195-206.
9. Sarvas H, Rautonen N, Mäkelä O. Allotype-associated differences in concentrations of human IgG subclasses. J Clin Immunol 1991: 11: 39-45.
10. Rautonen N, Sarvas H, Mäkelä O. One allele [G2m (n)] of the human IgG2 locus is more productive than the other. Eur J Immunol 1989: 19: 817-22.
11. Herrmann DJ, Hamilton RG, Barington T et al. Quantitation of human IgG subclass antibodies to Haemophiius influenzae type b capsular polysaccharide. Results of an international collaborative study using enzyme immunoaesay methodology. J Immunol Meth 1992: 148: 101-14.
12. Rautonen N, Pelkonen J, Sipinen S, Käyhty H, Mäkelä O. Isotype concentrations of human antibodies to group A meningococcal polysaccharide. J Immunol 1986: 137: 2670-5.
13. Sarvas H, Rautonen N, Sipinen S, Mäkelä O. IgG subclasses of pneumococcal antibodies - Effect of allotype G2m (n). Scand J Immunol 1989: 29: 229-37.
14. Granoff DM, Suarez BK, Pandey JP, Shackelford PG. Genes associated with the G2m (23) immunoglobulin allotype regulate the IgG subclass responses to Haemophilus influenzae type b polysaccharide vaccine. J Infect Dis 1988: 157: 1142-9.
15. Konradsen HB, Oxelius V-A, Hahn-Zoric M, Hanson LÅ. The importance of G1m and 2 allotypes for the IgG2 antibody levels and avidity against pneumococcal polysaccharide type 1 within mono- and dizygotic twin-pairs. Scand J Immunol 1994: 40: 251-6.
16. Ambrosino DM, Schiffman G, Gotschlich EC et al. Correlation between G2m (n) immunoglobulin allotype and human antibody response and susceptibility to polysaccharide encapsulated bacteria. J Clin Invest 1985: 75: 1935-42.
17. Ellison J, Hood L. Linkage and sequence homology of two human immunoglobulin γ heavy chain constant region genes. Proc Natl Acad Sci U S A 1982: 79: 1984-8.
18. Hougs L, Svejgaard A, Barington T. The first constant-domain (CH1) exon of human IGHG2 is polymorphic and in strong linkage disequilibrium with the CH2 exon polymorphism encoding the G2m (n+) allotype in Caucasians. Immunogenetics 2001: 52: 242-8.
19. Madsen HO, Satz ML, Hogh B, Svejgaard A, Garred P. Different molecular events result in low protein levels of mannan-binding lectin in populations from southeast Africa and South America. J Immunol 1998: 161: 3169-75.
20. Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucl Acids Res 1988: 16: 1215.
21. Sambrook J, Fritsch EF, Maniatis T. Molecular Cloning, a Laboratory Manual, 2nd edn. Cold Spring Harbor, NY: Cold Spring Harbor Laboratories, 1989.
22. Sanger F, Nicklen S, Coulson AR. DNA sequencing with chain terminating inhibitors. Proc Natl Acad Sci U S A 1977: 74: 5463-8.
23. Tindall KR, Kunkel TA. Fidelity of DNA synthesis by the Thermus aquaticus DNA polymerase. Biochemistry 1988: 27: 6008-13.
24. Takahashi N, Ueda S, Obata M, Nikaido T, Nakai S, Honjo T. Structure of human immunoglobulin gamma genes: implications for evolution of a gene family. Cell 1982: 29: 671-9.
25. Huck S, Fort P, Crawford DH, Lefranc M-P, Lefranc G. Sequence of a human immunoglobulin gamma 3 heavy chain constant region gene: comparison with the other human Cγ genes. Nucl Acids Res 1986: 14: 1779-89.
26. Schneider WP, Wensel TG, Stryer L, Oi VT. Genetically engineered immunoglobulins reveal structural features controlling segmental flexibility. Proc Natl Acad Sci U S A 1988: 85: 2509-13.
27. Cavalli-Sforza LL, Piazza A, Menozzi P, Mountain J. Reconstruction of human evolution: bringing together genetic, archaeological, and linguistic data. Proc Natl Acad Sci U S A 1988: 85: 6002-6.
28. Templeton AR. Out of Africa again and again. Nature 2002: 416: 45-51.
29. Propert D. Immunoglobulin allotypes and RFLPs in disease association. Exp Clin Immunogenet 1995: 12: 198-205.
30. Fraser GR, Volkers WS, Bernini LF, van Loghem E, Meera Khan P, Nijenhuis LE. Gene frequencies in a Dutch population. Hum Hered 1974: 24: 435-48.
31. Rautonen N, Seppälä I, Hallberg T, Grubb R, Mäkelä O. Determination of homozygosity or heterozygosity for the G2m (n) allotype by a monoclonal, precipitating antibody. Exp Clin Immunogenet 1989: 6: 31-8.