Simultaneous determination of spirapril and spiraprilat in plasma by capillary gas chromatography-mass spectrometry

Arzneimittel-Forschung/Drug Research

Volumn 53, Issue 5, 2003, Pages 307-313

  Schürer, Michael ^a   Amschler, Stefan ^a   Schulz, Hans Ulrich ^a   Schäfer, Harald F ^b  

^a Clin Pharmacol/B   (Germany)

^b Arzneimittelwerk Dresden GmbH   (Germany)

Author keywords

CAS 83602 05 5; CAS 94841 17 5; Spirapril, determination in plasma; Spiraprilat, determination in plasma

Indexed keywords

SPIRAPRIL; SPIRAPRILAT;

ACCURACY; ANALYTIC METHOD; ARTICLE; CAPILLARY GAS CHROMATOGRAPHY; DERIVATIZATION; DRUG DETERMINATION; DRUG STRUCTURE; FREEZING; HUMAN; ION MONITORING; MASS SPECTROMETRY; PLASMA; SAMPLING; SOLID PHASE EXTRACTION; STANDARD;

EID: 0038184185     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1297114     Document Type: Article

References (6)

1. Noble, S., Sorkin, E. M., Spirapril - A premilinary review of its pharmacology and pharmaceutic efficacy in the treatment of hypertension. Drugs 49, 750 (1995) (updated in May 1998)
2. Krähenbühl, S., Grass, P., Surve, A. et al., Pharmacokinetics and haemodynamic effects of a single oral dose of the novel ACE inhibitor spirapril in patients with chronic liver disease. Eur. J. Clin. Pharmacol. 45, 247 (1993)
3. Stein, G., Sierakowski, B., Grass, P. et al., Pharmacokinetics of spirapril and spiraprilat in patients with chronic renal failure. Blood Pressure a (Suppl. 2), 47 (1994)
4. Grass, P., Gerbeau, C., Kutz, K., Spirapril: Pharmacokinetic properties and drug interactions. Blood Pressure 3 (Suppl. 2), 7 (1994)
5. Hossein-Nia, M., Surve, A. H., Weglein, R. et al., Radioimmunoassays for spirapril and its active metabolite spiraprilate: Performance and application. Ther. Drug Monitor. 14, 234 (1992)
6. 2) and its application to gas chromatographic analysis of fatty acids. Chem. Pharm. Bull. 29, 1475 (1981)