Non-adrenergic non-cholinergic excitatory innervation in the airways: Role of neurokinin-2 receptors

Autonomic and Autacoid Pharmacology

Volumn 22, Issue 4, 2002, Pages 215-224

  Krishnakumar, S ^a   Holmes, E P ^a   Moore, R M ^a   Kappel, L ^a   Venugopal, C S ^a  

^a LOUISIANA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; ANTIHISTAMINIC AGENT; ATROPINE; CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); CYPROHEPTADINE; ENDOTHELIN; ENDOTHELIN 1 [11-21]; ENDOTHELIN RECEPTOR ANTAGONIST; HISTAMINE; MEPYRAMINE MALEATE; NEUROKININ 2 RECEPTOR; NEUROKININ 2 RECEPTOR ANTAGONIST; NEUROKININ A; NEUROKININ A [4-10][5 TYROSINE 6,8,9 DEXTRO TRYPTOPHAN 10 LYSINE]; OVALBUMIN; PRAZOSIN; PROPRANOLOL; SEROTONIN; SEROTONIN ANTAGONIST; TACHYKININ RECEPTOR ANTAGONIST;

ADRENERGIC RECEPTOR BLOCKING; ADRENERGIC SYSTEM; AIRWAY OBSTRUCTION; ALLERGENICITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; ATTENUATION; AUTONOMIC INNERVATION; BLOOD GAS ANALYSIS; BRONCHOSPASM; CANNULATION; CAROTID ARTERY; CHOLINERGIC RECEPTOR BLOCKING; CLAMP; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG EFFECT; DRUG RECEPTOR BINDING; EVALUATION; FEMALE; GUINEA PIG; HYPOTENSION; INHIBITION KINETICS; JUGULAR VEIN; LUNG VENTILATION; MALE; NEUROTRANSMITTER RELEASE; NONADRENERGIC NONCHOLINERGIC NERVE; NONHUMAN; PRESSURE TRANSDUCER; RECEPTOR BINDING; RESPIRATORY AIRFLOW; STATISTICAL SIGNIFICANCE; SURGICAL TECHNIQUE; SYMPATHETIC NERVE; TRACHEAL POUCH TECHNIQUE; VAGUS NERVE; VAGUS NERVE STIMULATION;

ADRENERGIC FIBERS; ANIMALS; BRONCHOCONSTRICTION; CHOLINERGIC FIBERS; FEMALE; GUINEA PIGS; MALE; NEUROKININ A; RECEPTORS, NEUROKININ-2; TRACHEA; VAGUS NERVE;

EID: 0038177735     PISSN: 14748665     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1474-8673.2002.00262.x     Document Type: Article

References (48)

1. BARNES, P.J. (1990). Neurogenic inflammation in airways and its modulation. Arch. Int. Pharmacodyn. Ther., 303, 67-82.
2. BARNES, P.J., BARANIUK, J.N. & BELVISI, M.G. (1991). Neuropeptides in the respiratory tract. Part II. Am. Rev. Respir. Dis., 144, 1391-1399.
3. BARNES, P.J., CHUNG, K.F. & PAGE, C.P. (1998). Inflammatory mediators of asthma: an update. Pharmacol. Rev., 50, 517-572.
4. BERTRAND, C., GEPPETTI, P., GRAF, P.D., FORESI, A. & NADEL, J.A. (1993). Involvement of neurogenic inflammation in antigen-induced bronchoconstriction in guinea pigs. Am. J. Physiol., 265, L507-L511.
5. BONI, P., BALLATI, L. & EVANGELISTA, S. (1995). Tachykinin NK1 and NK2 receptors mediate the non-cholinergic bronchospastic response to capsaicin and vagal stimulation in guinea-pigs. J. Auton. Pharmacol., 15, 49-54.
6. CHAN, C.C., TOUSIGNANT, C., HO, E., BRIDEAU, C., SAVOIE, C. & RODGER, I.W. (1994). Evaluation of bronchoconstriction induced by neurokinins and its inhibition by selective non-peptide antagonists in conscious guinea pigs, using a double-chamber plethysmograph technique. Can. J. Physiol. Pharmacol., 72, 11-18.
7. CHESROWN, S.E., VENUGOPALAN, C.S., GOLD, W.M. & DRAZEN, J.M. (1980). In-vivo demonstration of non-adrenergic inhibitory innervation of guinea pig trachea. J. Clin. Invest., 65, 314-320.
8. COBURN, R.F. & TOMITA, T. (1973). Evidence for a non-adrenergic nerves in the guinea pig trachealis muscle. Am. Physiol., 224, 1072-1080.
9. COLEMAN, R.A. LEVY, G.P. (1974). Evidence for a non-adrenergic inhibitory nervous pathway in guinea pig trachea. Br. J. Pharmacol., 52, 167-174.
10. DIAMOND, L. & O'DONNELL, M. (1980). A non-adrenergic vagal inhibitory pathway to feline airways. Science, 208, 185-188.
11. DJOKIC, T., BORSON, B., GRAF, P. & NADEL, J. (1989). Inhibitors of neutral endopeptidase potentiate electrically and capsaicin-induced non-cholinergic contraction in guinea pig bronchi. J. Pharmacol. Exp. Ther., 248, 7-11.
12. 2 receptor mediated inhibition of immediate type hypersensitivity reactions in vivo. Am. Rev. Respir. Dis., 117, 479-484.
13. DUPONT, L.J., MEADE, C.J., DEMEDTS, M.G. & VERLEDEN, G.M. (1996). Epinastine (WAL 801CL) modulates the non-cholinergic contraction in guinea-pig airways in vitro by a prejunctional 5-HT1 -like receptor. Eur. Respir. J., 9, 1433-1438.
14. FISCHER, A. MCGREGOR, G.P., SARIA, A., PHILIPIN, B. & KUMMER, W. (1996). Induction of tachykinin gene and peptide expression in guinea pig nodose primary afferent neurons by allergic airway inflammation. J. Clin. Invest., 98, 2284-2291.
15. FLOCH, A., THIRY, C. & CAVERO, I. (1996). Pharmacological evidence that NK-2 tachykinin receptors mediate hypotension in the guinea pig but not in the rat. Fundam. Clin. Pharmacol., 10, 337-343.
16. GRUNDSTROM, N. & ANDERSSON, R.G.G. (1982). A non-adrenergic, non-cholinergic neuronal component mediating slowly declining contraction in the guinea pig airways. Br. J. Pharmacol. 77 (Proc. Suppl.), 398P.
17. HALL, A.K., BARNES, P.J., MELDRUM, L.A. & MACLAGAN, J. (1989). Facilitation by tachykinins of neurotransmission in guinea-pig pulmonary parasympathetic nerves. Br. J. Pharmacol., 97, 274-280.
18. HSIUE, T.R., GARLAND, A., RAY, D.W., HERSHENSON, M.B., LEFF, A.R. & SOLWAY, J. (1992). Endogenous sensory neuropeptide release enhances non-specific airway responsiveness in guinea pigs. Am. Rev. Respir. Dis., 146, 148-153.
19. HUA, X.Y., THEODORSON-NORHEIM, E., BRODIN, E., LUNDBERG, J.M. & HOKFELT, T. (1985). Multiple tachykinins (neurokinin A, neuropeptide K and substance P) in capsaicin sensitive sensory neurons in the guinea pig. Regul. Pept., 13, 1-19.
20. JOOS, G.F. (1989). The role of sensory neuropeptides in the pathogenesis of bronchial asthma. Clin. Exp. Allergy., 19 (Suppl. 1), 9-13.
21. JOOS, G., PAUWELS, R. & VAN DER STRAETEN, M. (1987). Effect of inhaled substance P and neurokinin A on the airways of normal and asthmatic subjects. Thorax, 42, 779-783.
22. KARLSSON, J.A., FINNEY, M.J., PERSSON, C.G. & POST, C. (1984). Substance P antagonists and the role of tachykinins in non-cholinergic bronchoconstriction. Life Sci., 35, 2681-2691.
23. KRANEVELD, A.D., JAMES, D.E., DE VRIES, A. & NIJKAMP, F.P. (2000). Excitatory non-adrenergic-non-cholinergic neuropeptides: key players in asthma. Eur. J. Pharmacol., 405, 113-129.
24. LECHIN, F., VAN DER DIJS, B., OROZCO, B., LECHIN, M. & LECHIN, A.E. (1996). Increased levels of free serotonin in plasma of symptomatic asthmatic patients. Annu. Allergy Asthma Immunol., 77, 245-253.
25. LUNDBERG, J.M., BRODIN, E. & SARIA, A. (1983a). Effects and distribution of vagal capsaicin sensitive substance-P neurons with special reference to the trachea and lungs. Acta Physiol. Scand., 119, 243-252.
26. LUNDBERG, J.M. & SARIA, A. (1987). Polypeptide containing neurons in the airway smooth muscle. Annu. Rev. Physiol., 49, 557-572.
27. LUNDBERG, J.M., SARIA, A., BRODIN, E., ROSELL, S. & FOLKERS, K. (1983b). A substance-P antagonist inhibits vagally induced increase in vascular permeability and bronchial smooth muscle contraction in the guinea pig. Proc. Natl. Acad. Sci., 80, 1120-1124.
28. MAPP, C.E., MIOTTO, D., BRACCIONI, F., SAETTA, M., TURATO, G., MAESTRELLI, P., KRAUSE, J.E., KARPITSKIY, V., BOYD, N., GEPPETTI, P. & FABBRI, L.M. (2000). The distribution of neurokinin-1 and neurokinin-2 receptors in human central airways Am. J. Respir. Crit. Care. Medical, 161, 207-215.
29. MATSUSE, T., THOMSON, R.J., CHEN, X.R., SALARI, H. & SCHELLENBERG, R.R. (1991). Capsaicin inhibits airway hyperresponsiveness but not lipoxygenase activity or eosinophilia after repeated aerosolized antigen in guinea pigs. Am. Rev. Respir. Dis., 144, 368-372.
30. MATTOLI, S., SOLOPERTO, M., MARINI, M. & FASOLI, A. (1991). Levels of endothelin in the bronchoalveolar lavage fluid of patients with symptomatic asthma and reversible airflow obstruction. J. Allergy Clin. Immunol., 88, 376-384.
31. NALINE, E., DEVILLIER, P., DRAPEAU, G., TOTY, L., BAKDACH, H., REGOLI, D. & ADVENIER, C. (1989). Characterization of neurokinin effects and receptor selectivity in human isolated bronchi. Am. Rev. Respir. Dis., 140, 679-686.
32. PERRETTI, F., BALLATI, L., MANZINI, S., MAGGI, C.A. & EVANGELISTA, S. (1995). Antibronchospastic activity of MEN 10,627, a novel tachykinin NK2 receptor antagonist, in guinea-pig airways. Eur. J. Pharmacol., 273, 129-135.
33. PYPE, J.L., VERLEDEN, G.M. & DEMEDTS, M.G. (1994). 5-HT modulates non-cholinergic contraction in guinea pig airways in vitro by prejunctional 5-HT1-like receptor. J. Appl. Physiol., 77, 1135-1141.
34. REDINGTON, A.E., SPRINGALL, D.R., GHATEI, M.A., LAU, L.C., BLOOM, S.R., HOLGATE, S.T., POLAK, J.M. & HOWARTH, P.H. (1995). Endothelin in bronchoalveolar lavage fluid and its relation to airflow obstruction in asthma. Am. J. Respir. Crit. Care. Med., 151, 1034-1039.
35. RICHARDSON, J.B. (1979). Nerve supply to the lungs. Am. Rev. Resp. Dis., 119, 785-802.
36. SAVOIE, C., TOUSIGNANT, C., RODGER, I.W. & CHAN, C.C. (1995). Involvement of NK1 and NK-2 receptors in pulmonary responses elicited by non-adrenergic, non-cholinergic vagal stimulation in guinea-pigs. J. Pharm. Pharmacol., 47, 914-920.
37. SCHUILING, M., ZUDHOF, A.B., MEURS, H. & ZAAGSMA, J. (1999). Role of tachykinin NK2-receptor activation in the allergen-induced late asthmatic reaction, airway hyperreactivity and airway inflammatory cell influx in conscious, unrestrained guinea pigs. Br. J. Pharmacol., 127, 1030-1038.
38. SHORE, S.A. & DRAZEN, J.M. (1988). Enzymatic degradation of neurokinin-A modulates its bronchoactive properties: comparison with other neuropeptides. Am. Rev. Respir. Dis., 137, A200.
39. SHORE, S.A., GERARD, N.P., COATES, S.R. & DRAZEN, J.M. (1988). Substance-P induced bronchoconstriction in the guinea pig; Enhancement by inhibitors of neutral metallo endopeptidase and angiotensin converting enzyme. Am. Rev. Respir. Dis., 137, 331-336.
40. SOFIA, M., MORMILE, M., FARAONE, S., ALIFANO, M., ZOFRA, S., ROMANO, L. & CARRATU, L. (1993). Increased endothelin-like immunoreactive material on bronchoalveolar lavage fluid from patients with bronchial asthma and patients with interstitial lung disease. Respiration, 60, 89-95.
41. SZENTIVANYI, A. (1968). The beta-adrenergic theory of atopic abnormality in bronchial asthma. J. Allergy Clin. Immunol., 42, 203-220.
42. VENUGOPALAN, C.S., HOLMES, E.P., FUCCI, V. & GUTHRIE, A.J. (1991). Stimulation frequency-dependent non-adrenergic non-cholinergic airway responses of the guinea pig. J. Appl. Physiol., 70, 1006-1010.
43. VENUGOPALAN, C.S., HOLMES, E.P. & KLEINOW, K.M. (1995). Evidence for serotonin involvement in the NANC excitatory component in the catfish intestine. J. Auton. Pharmacol., 15, 37-48.
44. VENUGOPALAN, C.S. & O'MALLEY, N.A. (1988). Cross desensitization of VIP-and NANC-mediated inhibition of the guinea pig tracheal pouch. J. Auton. Pharmacol., 8, 53-61.
45. VENUGOPALAN, C.S., SAID, S.I. & DRAZEN, J.M. (1984). Effect of vasoactive intestinal peptide on vagally mediated tracheal pouch relaxation. Respir. Physiol., 56, 205-216.
46. WARD, J.K., FOX, A.J., BARNES, P.J. & BELVISI, M.G. (1994). Inhibition of excitatory non-adrenergic non-cholinergic bronchoconstriction in guinea-pig airways in vitro by activation of an atypical 5-HT receptor. Br. J. Pharmacol., 111, 1095-1102.
47. YOSHIHARA, S., GEPPETTI, P., LINDEN, A., HARA, M., CHAN, B. & NADEL, J.A. (1996). Tachykinins mediate the potentiation of antigen-induced bronchoconstriction by cold air in guinea pigs. J. Allergy Clin. Immunol., 97, 576-560.
48. YUAN, L., BURCHER, E. & NAIL, B. (1996). Tachykinin receptors and non-cholinergic bronchoconstriction in the anesthetized guinea-pig. Clin. Exp. Pharmacol. Physiol., 23, 119-124.