Insulin resistance and vascular remodelling, in relation to left ventricular mass, geometry and function: An answer to LIFE?

Journal of Human Hypertension

Volumn 17, Issue 5, 2003, Pages 299-304

  Lee, K W ^a   Lip, G Y H ^a  

^a UNIVERSITY DEPARTMENT OF MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSTERONE; CAPTOPRIL; INSULIN; RENIN;

CARDIOVASCULAR RISK; CLINICAL TRIAL; DISEASE ASSOCIATION; ECHOCARDIOGRAPHY; ESSENTIAL HYPERTENSION; HEART LEFT VENTRICLE FAILURE; HEART LEFT VENTRICLE FUNCTION; HEART LEFT VENTRICLE HYPERTROPHY; HEART LEFT VENTRICLE MASS; HUMAN; HYPERINSULINEMIA; HYPERTENSION; INSULIN RESISTANCE; INSULIN SENSITIVITY; MORBIDITY; MORTALITY; NOTE; OBESITY; PATHOPHYSIOLOGY; PROGNOSIS; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; VASCULAR RESISTANCE; VASCULAR SURGERY;

HUMANS; HYPERTENSION; HYPERTROPHY, LEFT VENTRICULAR; INSULIN RESISTANCE; MULTICENTER STUDIES; RANDOMIZED CONTROLLED TRIALS; VASCULAR RESISTANCE; VENTRICULAR FUNCTION, LEFT; VENTRICULAR REMODELING;

EID: 0038175323     PISSN: 09509240     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.jhh.1001561     Document Type: Note

References (44)

1. Olsen MH et al. Relative influence of insulin resistance versus blood pressure on vascular changes in long-standing hypertension. ICARUS, a LIFE substudy. Insulin Carotids US Scandinavia. J Hypertens 2000; 18: 75-81.
2. Olsen MH et al. A possible link between endothelial dysfunction and insulin resistance in hypertension. A LIFE substudy. Losartan Intervention for Endpoint-reduction in hypertension. Blood Pressure 2000; 9: 132-139.
3. Olsen MH et al. Are left ventricular mass, geometry and function related to vascular changes and/or insulin resistance in longstanding hypertension? ICARUS - A LIFE substudy. J Hum Hypertens 2003; 17: 305-311.
4. Koren MJ et al. Relation of left ventricular mass and geometry to morbidity and mortality in uncomplicated essential hypertension. Ann Intern Med 1991; 114: 345-352.
5. Verdecchia P et al. Prognostic value of left ventricular mass and geometry in systemic hypertension with left ventricular hypertrophy. Am J Cardiol 1996; 78: 197-202.
6. Feinstein SB, Voci P, Pizzuto F. Noninvasive surrogate markers of atherosclerosis. Am J Cardiol 2002; 89: 31C-43C.
7. Vaudo G et al. Arterial wall thickening at different sites and its association with left ventricular hypertrophy in newly diagnosed essential hypertension. Am J Hypertens 2000; 13: 324-331.
8. Schillaci G et al. Prognostic significance of left ventricular diastolic dysfunction in essential hypertension. J Am Coll Cardiol 2002; 39: 2005-2011.
9. Devereux RB et al. Left ventricular hypertrophy and geometric remodeling in hypertension: Stimuli, functional consequences and prognostic implications. J Hypertens Suppl 1994; 12: S117-S127.
10. Watanabe K et al. Effect of insulin resistance on left ventricular hypertrophy and dysfunction in essential hypertension. J Hypertens 1999; 17: 1153-1160.
11. Schillaci G et al. Left ventricular mass and systolic dysfunction in essential hypertension. J Hum Hypertens 2002; 16: 117-122.
12. Malmqvist K et al. Relationships between left ventricular mass and the renin-angiotensin system, catecholamines, insulin and leptin. J Intern Med 2002; 252: 430-439.
13. Olsen MH et al. Is cardiovascular remodeling in patients with essential hypertension related to more than high blood pressure? A LIFE substudy. Losartan Intervention for Endpoint-reduction in Hypertension. Am Heart J 2002; 144: 530-537.
14. DeFronzo RA, Ferranini E. Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care 1991; 14: 173-194.
15. Verdecchia P et al. Circulating insulin and insulin growth factor-1 are independent determinants of left ventricular mass and geometry in essential hypertension. Circulation 1999; 100: 1802-1807.
16. Devereux RB et al. Relation of insulin to left ventricular geometry and function in African American and white hypertensive adults: The HyperGEN study. Am J Hypertens 2002; 15: 1029-1035.
17. Jain A et al. Left ventricular diastolic function in hypertension and role of plasma glucose and insulin. Comparison with diabetic heart. Circulation 1996; 93: 1396-1402.
18. Jeng JR. Carotid wall thickening, left ventricular hypertrophy, and insulin resistance in patients with hypertension. Am J Hypertens 2002; 15: 422-425.
19. Vetta F et al. Hyperinsulinaemia, regional adipose tissue distribution and left ventricular mass in normotensive, elderly, obese subjects. Eur Heart J 1998; 19: 326-331.
20. Malmqvist K et al. Left ventricular mass is not related to insulin sensitivity in never-treated primary hypertension. J Hypertens 2001; 19: 311-317.
21. De Simone G et al. Association of left ventricular hypertrophy with metabolic risk factors: The HyperGEN study. J Hypertens 2002; 20: 323-331.
22. Messerli FH. Cardiovascular effects of obesity and hypertension. Lancet 1982; 1: 1165-1168.
23. Lauer MS et al. The impact of obesity on left ventricular mass and geometry. The Framingham Heart Study. JAMA 1991; 266: 231-236.
24. De Simone G et al. Relation of obesity and gender to left ventricular hypertrophy in normotensive and hypertensive adults. Hypertension 1994; 23: 600-606.
25. Steinberger J et al. Relation of insulin resistance and body composition to left ventricular mass in children. Am J Cardiol 2002; 90: 1177-1180.
26. Paternostro G et al. Insulin resistance in patients with cardiac hypertrophy. Cardiovasc Res 1999; 42: 246-253.
27. Olsen MH et al. Left ventricular hypertrophy is associated with reduced vasodilatory capacity in the brachial artery in patients with longstanding hypertension. A LIFE substudy. Blood Pressure 2002; 11: 285-292.
28. Olsen MH et al. Vasodilatory capacity and vascular structure in long-standing hypertension: A LIFE substudy. Losartan Intervention for Endpoint-reduction in hypertension. Am J Hypertens 2002; 15: 398-404.
29. Muiesan ML et al. Structural changes in small resistance arteries and left ventricular geometry in patients with primary and secondary hypertension. J Hypertens 2002; 20: 1439-1444.
30. Shigematsu Y et al. Left ventricular geometry as an independent predictor for extracardiac target organ damage in essential hypertension. Am J Hypertens 1998; 11: 1171-1177.
31. Olsen MH et al. The importance of changes in conduit and peripheral arteries for coronary flow reserve in patients with hypertension. A LIFE substudy. J Am Coll Cardiol 1999; 33: 279A.
32. Galderisi M et al. Coronary flow reserve and myocardial diastolic dysfunction in arterial hypertension. Am J Cardiol 2002; 90: 860-864.
33. Schafer S et al. Left ventricular remodeling impairs coronary flow reserve in hypertensive patients. J Hypertens 2002; 20: 1431-1437.
34. Pereira V et al. Coronary flow velocity reserve in hypertensive patients with left ventricular systolic dysfunction. Clin Cardiol 2002; 25: 95-102.
35. Matsumura Y et al. Left ventricular diastolic function assessed using Doppler tissue imaging in patients with hypertrophic cardiomyopathy: Relation to symptoms and exercise capacity. Heart 2002; 87: 247-251.
36. Pela G et al. Doppler tissue echocardiography: Myocardial wall motion velocities in essential hypertension. Eur J Echocardiogr 2001; 2: 108-117.
37. Giorgi D et al. Ultrasonic tissue characterization and Doppler tissue imaging in the analysis of left ventricular function in essential arterial hypertension: A preliminary study. Echocardiography 2002; 19: 187-198.
38. Weber KT. Cardioreparation in hypertensive heart disease. Hypertension 2001; 38: 588-591.
39. Gavras I, Gavras H. Angiotensin II as a cardiovascular risk factor. J Hum Hypertens 2002; 16 (Suppl. 2): S2-S6.
40. Ilercil A et al. Associations of insulin levels with left ventricular structure and function in American Indians: The strong heart study. Diabetes 2002; 51: 1543-1547.
41. Rheeder P et al. Insulin resistance syndrome and left ventricular mass in an elderly population (the Rotterdam Study). Am J Cardiol 1999; 84: 233-236, A9.
42. Lind L et al. Left ventricular hypertrophy in hypertension is associated with the insulin resistance metabolic syndrome. J Hypertens 1995; 13: 433-438.
43. Costa CH et al. Serum insulin levels, 24-hour blood pressure profile, and left ventricular mass in non-obese hypertensive patients. Hypertension 1995; 26: 1085-1088.
44. Sasson Z et al. Insulin resistance is an important determinant of left ventricular mass in the obese. Circulation 1993; 88: 1431-1436.