Clinical significance of co-expression of VEGF-C and VEGFR-3 in non-small cell lung cancer

Chinese Medical Journal

Volumn 116, Issue 5, 2003, Pages 727-730

  Li, Qingchang ^a   Dong, Xin ^a   Gu, Wei ^a   Qui, Xueshan ^a   Wang, Enhua ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Lung cancer; Metastasis; VEGF C; VEGFR 3

Indexed keywords

VASCULOTROPIN C; VASCULOTROPIN RECEPTOR 3;

ANGIOGENESIS; ARTICLE; CANCER CELL; CANCER INVASION; CANCER STAGING; CELL DIFFERENTIATION; CONTROLLED STUDY; CORRELATION FUNCTION; DENSITY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG NON SMALL CELL CANCER; LYMPH NODE METASTASIS; LYMPH VESSEL; MAJOR CLINICAL STUDY; MICROVASCULATURE; OUTCOMES RESEARCH; PREDICTION; PROGNOSIS; PROTEIN EXPRESSION; SAMPLING; WESTERN BLOTTING;

CARCINOMA, NON-SMALL-CELL LUNG; ENDOTHELIAL GROWTH FACTORS; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; VASCULAR ENDOTHELIAL GROWTH FACTOR C; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-3;

EID: 0038171310     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Karkkainen MJ, Makinen T, Alitalo K. Lymphatic endothelium: a new frontier of metastasis research. Nat Cell Biol 2002; 4:2-5.
2. Weidner N. Current pathologic methods for measuring intratum oral microvessel density within breast carcinoma and other solid tumors. Breast Cancer Res Treat 1995; 36:169-173.
3. Furudoi A, Tanaka S, Haruma K, et al. Clinical significance of vascular endothelial growth factor C expression and angiogenesis at the deepest invasive site of advanced colorectal carcinoma. Oncology 2002; 62:157-166.
4. Tsurusaki T, Kanda S, Sakai H, et al. Vascular endothelial growth factor-C expression in human prostatic carcinoma and its relationship to lymph node metastasis. Br J Cancer 1999; 80:309-313.
5. Yonemura Y, Fushida S, Bando E, et al. Lymphangiogenesis and the vascular endothelial growth factor receptor (VEGFR)-3 in gastric cancer. Eur J Cancer 2001; 37:918-923.
6. Oh SJ, Jeltsch MM, Birkenhager R, et al. VEGF and VEGF-C: specific induction of angiogenesis and lymphangiogenesis in the differentiated avian chorioallantoic membrane. Dev Biol 1997; 188:96-109.
7. Valtola R, Salven P, Heikkil P, et al. VEGFR-3 and its ligand VEGF-C are associated with angiogenesis in breast cancer. Am J Pathol 1999; 154:1381-1390.
8. Ohta Y, Shridhar V, Bright RK, et al. VEGF and VEGF type C play an important role in angiogenesis and lymphangiogenesis in human malignant mesothelioma tumours. Br J Cancer 1999; 81:54-61.
9. Eggert A, Ikegaki N, Kwiatkowski J, et al. High-level expression of angiogenic factors is associated with advanced tumor stage in human neuroblastomas. Clin Cancer Res 2000; 6:1900-1908.
10. Ueda M, Terai Y, Yamashita Y, et al. Correlation between vascular endothelial growth factor-C expression and invasion phenotype in cervical carcinomas. Int J Cancer 2002;98:335-343.
11. Kinoshita J, Kiramura K, Kavashima A, et al. Clinical significance of vascular endothelial growth factor-C (VEGF-C) in breast cancer. Breast Cancer Res Treat 2001; 66:159-164.
12. Mäkinen T, Veikkola T, Mustjoki S, et al. Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3. EMBO 12001; 20:4762-4773.