The biological consequences of replacing hydrophobic amino acids in deltorphin I with amphiphilic α-hydroxymethylamino acids

Journal of Peptide Research

Volumn 62, Issue 1, 2003, Pages 45-52

  Olma, A ^a   Lachwa M ^b   Lipkowski, A W ^b,c  

^a LODZ UNIVERSITY OF TECHNOLOGY   (Poland)

^b MOSSAKOWSKI MEDICAL RESEARCH CENTRE   (Poland)

^c INDUSTRIAL CHEMISTRY RESEARCH INSTITUTE   (Poland)

Author keywords

, disubstituted amino acids; hydroxymethylamino acids; Amphiphilic amino acids; Deltorphin I analogues; Opioid peptides; Opioid receptor binding

Indexed keywords

ALPHA HYDROXYMETHYLAMINO ACID DERIVATIVE; AMINO ACID DERIVATIVE; AMPHOPHILE; DELTA OPIATE RECEPTOR; DELTORPHIN; DELTORPHIN I; MU OPIATE RECEPTOR; PHENYLALANINE; UNCLASSIFIED DRUG; VALINE;

AMINO ACID ANALYSIS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; PEPTIDE ANALYSIS; PRIORITY JOURNAL; PROTEIN STRUCTURE; RECEPTOR AFFINITY;

AMINO ACID SUBSTITUTION; AMINO ACIDS; ANIMALS; HYDROPHOBICITY; HYDROXYLATION; METHYLATION; OLIGOPEPTIDES; PHENYLALANINE; PROTEIN BINDING; PROTEIN CONFORMATION; RATS; RECEPTORS, OPIOID; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SURFACE-ACTIVE AGENTS; VALINE;

EID: 0038171175     PISSN: 1397002X     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-3011.2003.00067.x     Document Type: Article

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