No evidence for association between the - 112G/A polymorphism of UGRP1 and childhood atopic asthma

Clinical and Experimental Allergy

Volumn 33, Issue 7, 2003, Pages 902-904

  Jian, Z ^a   Nakayama, J ^a   Noguchi, E ^a   Shibasaki, M ^b   Arinami, Tadao ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b TSUKUBA UNIVERSITY OF TECHNOLOGY   (Japan)

Author keywords

Association study; Asthma; Genetics; Polymorphism; UGRP1

Indexed keywords

ALLELE; ALLERGIC ASTHMA; ARTICLE; CHILD; CONTROLLED STUDY; GENE LINKAGE DISEQUILIBRIUM; GENE UGRP1; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENOTYPE; HUMAN; JAPAN; MAJOR CLINICAL STUDY; MARKER GENE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

ADOLESCENT; ADULT; AGED; ASTHMA; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MIDDLE AGED; POLYMORPHISM, GENETIC;

EID: 0038162282     PISSN: 09547894     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2222.2003.01703.x     Document Type: Article

References (11)

1. The Collaborative Study on the Genetics of Asthma (CSGA). A genome-wide search for asthma susceptibility loci in ethnically diverse populations. Nat Genet 1997; 15:389-92.
2. Ober C, Cox NJ, Abney M et al. Genome-wide search for asthma susceptibility loci in a founder population. The Collaborative Study on the Genetics of Asthma. Hum Mol Genet 1998; 7:1393-8.
3. Yokouchi Y, Nukaga Y, Shibasaki M et al. Significant evidence for linkage of mite-sensitive childhood asthma to chromosome 5q31-q33 near the interleukin 12 B locus by a genome-wide search in Japanese families. Genomics 2000; 66:152-60.
4. Marsh DG, Neely JD, Breazeale DR et al. Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations. Science 1994; 264:1152-6.
5. Postma DS, Bleecker ER, Amelung PJ et al. Genetic susceptibility to asthma-bronchial hyperresponsiveness coinherited with a major gene for atopy. N Engl J Med 1995; 333:894-900.
6. Niimi T, Keck-Waggoner CL, Popescu NC, Zhou Y, Levitt RC, Kimura S. UGRP1, a uteroglobin/Clara cell secretory protein-related protein, is a novel lung-enriched downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor. Mol Endocrinol 2001; 15:2021-36.
7. Niimi T, Munakata M, Keck-Waggoner CL et al. A polymorphism in the human UGRP1 gene promoter that regulates transcription is associated with an increased risk of asthma. Am J Hum Genet 2002; 70:718-25.
8. Busse W, Banks-Schlegel SP, Larsen GL. Childhood- versus adult-onset asthma. Am J Respir Crit Care Med 1995; 151:1635-9.
9. Larsen GL. Differences between adult and childhood asthma. J Allergy Clin Immunol 2000; 106:S153-7.
10. Watson TM, Reynolds SD, Mango GW, Boe IM, Lund J, Stripp BR. Altered lung gene expression in CCSP-null mice suggests immunoregulatory roles for Clara cells. Am J Physiol Lung Cell Mol Physiol 2001; 281:L1523-30.
11. Wang SZ, Rosenberger CL, Espindola TM et al. CCSP modulates airway dysfunction and host responses in an Ova-challenged mouse model. Am J Physiol Lung Cell Mol Physiol 2001; 281:L1303-11.